(Q38000475)

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Bioactive compounds synthesized by non-ribosomal peptide synthetases and type-I polyketide synthases discovered through genome-mining and metagenomics

scientific article published on 06 April 2012

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scholarly article

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Europe PubMed Central

PubMed publication ID

26 August 2017

Bioactive compounds synthesized by non-ribosomal peptide synthetases and type-I polyketide synthases discovered through genome-mining and metagenomics (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

1 reference

based on heuristic

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author name string

Katerina Nikolouli

1

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

Dimitris Mossialos

2

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

publication date

6 April 2012

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Europe PubMed Central

PubMed publication ID

26 August 2017

Biotechnology Letters

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Europe PubMed Central

PubMed publication ID

26 August 2017

34

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Europe PubMed Central

PubMed publication ID

26 August 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

1393-1403

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

https://scigraph.springernature.com/pub.10.1007/s10529-012-0919-2

0 references

Evolution and taxonomic distribution of nonribosomal peptide and polyketide synthases

1 reference

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Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans

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Possibility of bacterial recruitment of plant genes associated with the biosynthesis of secondary metabolites

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Genome mining for novel natural product discovery

1 reference

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Coelichelin, a new peptide siderophore encoded by the Streptomyces coelicolor genome: structure prediction from the sequence of its non-ribosomal peptide synthetase

1 reference

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Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway

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Recent progress and new challenges in metagenomics for biotechnology

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New antibiotics from bacterial natural products

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Structure guided approaches toward exploiting and manipulating nonribosomal peptide and polyketide biosynthetic pathways

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Evidence for the biosynthesis of bryostatins by the bacterial symbiont "Candidatus Endobugula sertula" of the bryozoan Bugula neritina

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Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics

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An oxidation domain in the BlmIII non-ribosomal peptide synthetase probably catalyzing thiazole formation in the biosynthesis of the anti-tumor drug bleomycin in Streptomyces verticillus ATCC15003.

1 reference

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Hybrid peptide-polyketide natural products: biosynthesis and prospects toward engineering novel molecules

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Biosynthesis of nonribosomal peptides1.

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The activation of amino acids for biosynthesis of gramicidin S.

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Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage

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The genomisotopic approach: a systematic method to isolate products of orphan biosynthetic gene clusters

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bryA: an unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina

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Polyketide synthases of bacterial symbionts in sponges--evolution-based applications in natural products research

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Identification and characterization of the pyridomycin biosynthetic gene cluster of Streptomyces pyridomyceticus NRRL B-2517.

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Biosynthesis and structure of aeruginoside 126A and 126B, cyanobacterial peptide glycosides bearing a 2-carboxy-6-hydroxyoctahydroindole moiety

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Plasticity and evolution of aeruginosin biosynthesis in cyanobacteria

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Bioinformatic perspectives on NRPS/PKS megasynthases: advances and challenges

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Evolution of metabolic diversity: insights from microbial polyketide synthases

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Evolutionary implications of bacterial polyketide synthases

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Natural biocombinatorics in the polyketide synthase genes of the actinobacterium Streptomyces avermitilis

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Marine metagenomics: new tools for the study and exploitation of marine microbial metabolism.

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Macrocyclization strategies in polyketide and nonribosomal peptide biosynthesis

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Discovery of a new peptide natural product by Streptomyces coelicolor genome mining

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Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus

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The Genomes On Line Database (GOLD) in 2009: status of genomic and metagenomic projects and their associated metadata

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Engineering of an "unnatural" natural product by swapping polyketide synthase domains in Aspergillus nidulans

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Isolation and identification of rhizoxin analogs from Pseudomonas fluorescens Pf-5 by using a genomic mining strategy

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The metagenomics RAST server - a public resource for the automatic phylogenetic and functional analysis of metagenomes

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Homologs of aminoacyl-tRNA synthetases acylate carrier proteins and provide a link between ribosomal and nonribosomal peptide synthesis

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A new approach to retrieve full lengths of functional genes from soil by PCR-DGGE and metagenome walking

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Polyketide synthase pathways identified from a metagenomic library are derived from soil Acidobacteria

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Insights into antibiotic resistance through metagenomic approaches.

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Multimodular biocatalysts for natural product assembly.

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Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140.

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Crystal structure of the termination module of a nonribosomal peptide synthetase

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Identifiers

10.1007/S10529-012-0919-2

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 August 2017

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