(Q38007827)

26 August 2017

Innate and adaptive immune responses in asthma (English)

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26 August 2017

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1

Stephen T Holgate

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PubMed ID

22561831

26 August 2017

language of work or name

English

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publication date

4 May 2012

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26 August 2017

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26 August 2017

18

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26 August 2017

5

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26 August 2017

673-683

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https://scigraph.springernature.com/pub.10.1038/nm.2731

26 August 2017

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Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness

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Interleukin-17 is a negative regulator of established allergic asthma

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CD28 and CTLA-4 coreceptor expression and signal transduction

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IL-13 Mediates In Vivo IL-9 Activities on Lung Epithelial Cells but Not on Hematopoietic Cells

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Sequential class switching is required for the generation of high affinity IgE antibodies

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Intrinsic asthma: not so different from allergic asthma but driven by superantigens?

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Allergy is rare where butterflies flourish in a biodiverse environment

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Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression

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Myeloid and plasmacytoid dendritic cells in induced sputum after allergen inhalation in subjects with asthma

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Development and function of TH17 cells in health and disease

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Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma

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12 December 2020

Isolation of human blood DC subtypes

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12 December 2020

Intrinsic phenotypic differences of asthmatic epithelium and its inflammatory responses to respiratory syncytial virus and air pollution

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Segmental allergen challenge in patients with atopic asthma leads to increased IL-9 expression in bronchoalveolar lavage fluid lymphocytes

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12 December 2020

Pharmacological targeting of anaphylatoxin receptors during the effector phase of allergic asthma suppresses airway hyperresponsiveness and airway inflammation

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Exposure to environmental microorganisms and childhood asthma

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12 December 2020

Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells

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12 December 2020

Pharmacological characterization of MK-7246, a potent and selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells) antagonist

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12 December 2020

Role of B7-CD28/CTLA-4 costimulation and NF-kappa B in allergen-induced T cell chemotaxis by IL-16 and RANTES

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12 December 2020

Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis.

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12 December 2020

Ligation of cytotoxic T lymphocyte antigen-4 to T cell receptor inhibits T cell activation and directs differentiation into Foxp3+ regulatory T cells

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Evidence for diminished levels of epithelial psoriasin and calprotectin in chronic rhinosinusitis

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12 December 2020

Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes

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Rhinovirus-induced bronchiolitis and asthma development

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Filaggrin in atopic dermatitis

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A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study

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Pathophysiology of asthma: what has our current understanding taught us about new therapeutic approaches?

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Invariant NKT cells are required for airway inflammation induced by environmental antigens

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Childhood asthma after bacterial colonization of the airway in neonates

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IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction

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12 December 2020

Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study

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12 December 2020

Importance of the personal endotoxin cloud in school-age children with asthma

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12 December 2020

Prostaglandin D2 as a mediator of allergic asthma

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12 December 2020

STAT6-dependent regulation of Th9 development

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12 December 2020

Development of the airway intraepithelial dendritic cell network in the rat from class II major histocompatibility (Ia)-negative precursors: differential regulation of Ia expression at different levels of the respiratory tract.

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12 December 2020

Cytokine/anti-cytokine therapy - novel treatments for asthma?

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12 December 2020

Maternal TLR signaling is required for prenatal asthma protection by the nonpathogenic microbe Acinetobacter lwoffii F78

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12 December 2020

Inflammatory dendritic cells--not basophils--are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen

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12 December 2020

CTLA-4-Ig therapy diminishes the frequency but enhances the function of Treg cells in patients with rheumatoid arthritis

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12 December 2020

Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset.

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12 December 2020

Rapid dendritic cell recruitment is a hallmark of the acute inflammatory response at mucosal surfaces

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12 December 2020

MEDI-563, a humanized anti–IL-5 receptor α mAb with enhanced antibody-dependent cell-mediated cytotoxicity function

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12 December 2020

Lebrikizumab treatment in adults with asthma

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12 December 2020

A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation

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12 December 2020

Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD.

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12 December 2020

Differential gene expression and cytokine production from neutrophils in asthma phenotypes

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12 December 2020

Decreased activation of inflammatory networks during acute asthma exacerbations is associated with chronic airflow obstruction

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12 December 2020

Mepolizumab and exacerbations of refractory eosinophilic asthma

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12 December 2020

IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells

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12 December 2020

Regulation of inflammatory responses by IL-17F

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12 December 2020

Chemokine receptor 4 plays a key role in T cell recruitment into the airways of asthmatic patients

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12 December 2020

CD23/FcεRII: molecular multi-tasking

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12 December 2020

The allergy gene: how a mutation in a skin protein revealed a link between eczema and asthma

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12 December 2020

Intestinal barrier function: molecular regulation and disease pathogenesis

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12 December 2020

Understanding the genetic regulation of IgE production

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12 December 2020

Complement activation pathways: a bridge between innate and adaptive immune responses in asthma

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12 December 2020

A randomized, double-blind, placebo-controlled study of tumor necrosis factor-α blockade in severe persistent asthma

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12 December 2020

Macrophages and dendritic cells express tight junction proteins and exchange particles in an in vitro model of the human airway wall.

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12 December 2020

Disordered microbial communities in asthmatic airways

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12 December 2020

Barnyard microbes and childhood asthma

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12 December 2020

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

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12 December 2020

Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus

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12 December 2020

Absence of the complement anaphylatoxin C3a receptor suppresses Th2 effector functions in a murine model of pulmonary allergy.

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12 December 2020

Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses

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12 December 2020

A large-scale, consortium-based genomewide association study of asthma

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12 December 2020

Reciprocal expression of IL-25 and IL-17A is important for allergic airways hyperreactivity

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12 December 2020

Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

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12 December 2020

Pathogen recognition and innate immunity

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12 December 2020

Safety profile and clinical activity of multiple subcutaneous doses of MEDI-528, a humanized anti-interleukin-9 monoclonal antibody, in two randomized phase 2a studies in subjects with asthma

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12 December 2020

Functional specialization of interleukin-17 family members

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12 December 2020

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

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12 December 2020

Farm living: effects on childhood asthma and allergy

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12 December 2020

Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity

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12 December 2020

The effects of an anti-CD4 monoclonal antibody, keliximab, on peripheral blood CD4+ T-cells in asthma

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12 December 2020

Reslizumab in children and adolescents with eosinophilic esophagitis: results of a double-blind, randomized, placebo-controlled trial.

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12 December 2020

Interactions of airway epithelium with protease allergens in the allergic response

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12 December 2020

Not all farming environments protect against the development of asthma and wheeze in children.

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12 December 2020

Activation of airway epithelial cells by toll-like receptor agonists

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12 December 2020

Enhancement of neutrophil function by the bronchial epithelium stimulated by epidermal growth factor.

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12 December 2020

Effects of smoking cessation on lung function and airway inflammation in smokers with asthma.

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12 December 2020

CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner

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12 December 2020

Invariant natural killer T cells in asthma and chronic obstructive pulmonary disease.

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12 December 2020

The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics

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12 December 2020

Evidence for a causal relationship between allergic sensitization and rhinovirus wheezing in early life

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12 December 2020

Spatiotemporal and functional behavior of airway dendritic cells visualized by two-photon microscopy.

1 reference

12 December 2020

Randomised, dose-ranging, placebo-controlled study of chimeric antibody to CD4 (keliximab) in chronic severe asthma

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12 December 2020

Role of deficient type III interferon-λ production in asthma exacerbations

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12 December 2020

A rational approach to the management of severe refractory asthma

1 reference

12 December 2020

A role for the C3a anaphylatoxin receptor in the effector phase of asthma

1 reference

12 December 2020

High serum levels of tumour necrosis factor-alpha and interleukin-8 in severe asthma: markers of systemic inflammation?

1 reference

12 December 2020

Dendritic cells are recruited into the airway epithelium during the inflammatory response to a broad spectrum of stimuli

1 reference

12 December 2020

Identification of a novel subset of human circulating memory CD4(+) T cells that produce both IL-17A and IL-4.

1 reference

12 December 2020

Prostaglandin D2 receptors DP and CRTH2 in the pathogenesis of asthma

1 reference

12 December 2020

Airborne endotoxin in homes with domestic animals: implications for cat-specific tolerance

1 reference

12 December 2020

MicroRNA-21 limits in vivo immune response-mediated activation of the IL-12/IFN-gamma pathway, Th1 polarization, and the severity of delayed-type hypersensitivity

1 reference

12 December 2020

Prenatal exposure to a farm environment modifies atopic sensitization at birth

1 reference

12 December 2020

Germ-free status and altered caecal subdominant microbiota are associated with a high susceptibility to cow's milk allergy in mice

1 reference

12 December 2020

IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses

1 reference

12 December 2020

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

1 reference

12 December 2020

How are T(H)2-type immune responses initiated and amplified?

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12 December 2020

IL-9 and its receptor in allergic and nonallergic lung disease: increased expression in asthma

1 reference

12 December 2020

Making sense of regulatory T cell suppressive function

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12 December 2020

Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero

1 reference

12 December 2020

Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals

1 reference

12 December 2020

Control of cytokine gene transcription in Th1 and Th2 cells.

1 reference

12 December 2020

A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma

1 reference

12 December 2020

Allergic sensitization is associated with rhinovirus-, but not other virus-, induced wheezing in children

1 reference

12 December 2020

Local expression of ϵ germline gene transcripts and RNA for the ϵ heavy chain of IgE in the bronchial mucosa in atopic and nonatopic asthma

1 reference

12 December 2020

IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways

1 reference

12 December 2020

Defucosylated anti CC chemokine receptor 4 monoclonal antibody combined with immunomodulatory cytokines: a novel immunotherapy for aggressive/refractory Mycosis fungoides and Sezary syndrome

1 reference

12 December 2020

A cascade of cytokines is responsible for IL-9 expression in human T cells. Involvement of IL-2, IL-4, and IL-10

1 reference

12 December 2020

Essential role for both CD80 and CD86 costimulation, but not CD40 interactions, in allergen-induced Th2 cytokine production from asthmatic bronchial tissue: role for alphabeta, but not gammadelta, T cells

1 reference

12 December 2020

Revolution 9: the backwards and forwards evidence surrounding interleukin-9

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12 December 2020

Nasal IL-5 levels determine the response to anti-IL-5 treatment in patients with nasal polyps.

1 reference

12 December 2020

Mechanisms of allergen-specific immunotherapy

1 reference

12 December 2020

Disease-associated functions of IL-33: the new kid in the IL-1 family

1 reference

12 December 2020

The danger within: endogenous danger signals, atopy and asthma

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12 December 2020

Mepolizumab in eosinophilic disorders

1 reference

12 December 2020

Interleukin-2 receptor antagonists in liver transplantation: a meta-analysis of randomized trials

1 reference

12 December 2020

IL-17-producing T cells in lung immunity and inflammation

1 reference

12 December 2020

Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells.

1 reference

12 December 2020

Mepolizumab for prednisone-dependent asthma with sputum eosinophilia

1 reference

12 December 2020

Blockade of CCR4 in a humanized model of asthma reveals a critical role for DC-derived CCL17 and CCL22 in attracting Th2 cells and inducing airway inflammation.

1 reference

12 December 2020

The role of CD28-B7 costimulation in allergen-induced cytokine release by bronchial mucosa from patients with moderately severe asthma

1 reference

12 December 2020

Reslizumab for Poorly Controlled, Eosinophilic Asthma

1 reference

12 December 2020

Animal models of asthma: value, limitations and opportunities for alternative approaches

1 reference

12 December 2020

High-Affinity IgE Receptors on Dendritic Cells Exacerbate Th2-Dependent Inflammation

1 reference

12 December 2020

Exogenous IFN-β has antiviral and anti-inflammatory properties in primary bronchial epithelial cells from asthmatic subjects exposed to rhinovirus.

1 reference

12 December 2020

Human invariant V alpha 24-J alpha Q TCR supports the development of CD1d-dependent NK1.1+ and NK1.1- T cells in transgenic mice

1 reference

12 December 2020

Rhinovirus disrupts the barrier function of polarized airway epithelial cells

1 reference

12 December 2020

Interleukin-9 enhances resistance to the intestinal nematode Trichuris muris.

1 reference

12 December 2020

Daclizumab improves asthma control in patients with moderate to severe persistent asthma: a randomized, controlled trial

1 reference

12 December 2020

Reduced structural proteins in the conjunctival epithelium in allergic eye disease.

1 reference

12 December 2020

Allergic diseases and atopic sensitization in children related to farming and anthroposophic lifestyle--the PARSIFAL study.

1 reference

12 December 2020

Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children

1 reference

12 December 2020

Selective depletion of Foxp3+ Treg during sensitization phase aggravates experimental allergic airway inflammation

1 reference

12 December 2020

Identifiers

DOI

10.1038/NM.2731

1 reference

26 August 2017

1 reference

PubMed ID

22561831