(Q38010820)

26 August 2017

title

Modulators of Na/K-ATPase: a patent review (English)

1 reference

26 August 2017

George A O'Doherty

2

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author name string

Hua-Yu Leo Wang

series ordinal

1

1 reference

26 August 2017

language of work or name

English

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publication date

17 May 2012

1 reference

Expert Opinion on Therapeutic Patents

26 August 2017

published in

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26 August 2017

volume

22

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26 August 2017

issue

6

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26 August 2017

page(s)

587-605

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Annual review prize lecture. 'All hands to the sodium pump'.

26 August 2017

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Crystal structure of the sodium–potassium pump

21 January 2018

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Crystal structure of the sodium-potassium pump at 2.4 A resolution

21 January 2018

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Crystal structure of the sodium-potassium pump (Na+,K+-ATPase) with bound potassium and ouabain

21 January 2018

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Structural insights into the high affinity binding of cardiotonic steroids to the Na+,K+-ATPase

21 January 2018

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In and out of the cation pumps: P-type ATPase structure revisited

21 January 2018

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A structural overview of the plasma membrane Na+,K+-ATPase and H+-ATPase ion pumps.

21 January 2018

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A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis

21 January 2018

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Physical mapping and characterization of the human Na,K-ATPase isoform, ATP1A4

21 January 2018

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Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart

21 January 2018

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Selectivity of digitalis glycosides for isoforms of human Na,K-ATPase

21 January 2018

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The sodium pump alpha1 sub-unit: a disease progression-related target for metastatic melanoma treatment

21 January 2018

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Targeting the Na(+)/K(+)-ATPase alpha1 subunit of hepatoma HepG2 cell line to induce apoptosis and cell cycle arresting

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.690033

The alpha1 subunit of the sodium pump could represent a novel target to combat non-small cell lung cancers

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.690033

The sodium pump alpha1 subunit as a potential target to combat apoptosis-resistant glioblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Na,K-adenosine triphosphatase alpha1-subunit predicts survival of renal clear cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Up-regulation of Na(+),K(+)-ATPase alpha 3-isoform and down-regulation of the alpha1-isoform in human colorectal cancer

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Cardiotonic steroids-mediated targeting of the Na(+)/K(+)-ATPase to combat chemoresistant cancers

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Identification of a pool of non-pumping Na/K-ATPase

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Na/K-ATPase tethers phospholipase C and IP3 receptor into a calcium-regulatory complex

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.690033

The Na/K-ATPase/Src complex and cardiotonic steroid-activated protein kinase cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Comparative properties of caveolar and noncaveolar preparations of kidney Na+/K+-ATPase

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Novel therapeutic applications of cardiac glycosides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Expression of Na+,K+-ATPase in Pichia pastoris: analysis of wild type and D369N mutant proteins by Fe2+-catalyzed oxidative cleavage and molecular modeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Transport and pharmacological properties of nine different human Na, K-ATPase isozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Functional expression of the alpha 2 and alpha 3 isoforms of the Na,K-ATPase in baculovirus-infected insect cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

The NA/K-ATPase and its isozymes: what we have learned using the baculovirus expression system

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Positive inotropic effects of ouabain in isolated cat ventricular myocytes in sodium-free conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Conformational dynamics of the Na+/K+-ATPase probed by voltage clamp fluorometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Development of an HTS assay for Na+, K+-ATPase using nonradioactive rubidium ion uptake.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Kinetics of cardiac glycoside binding to sodium, potassium adenosine triphosphatase studied with a fluorescent derivative of ouabain

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Interactions between cardiac glycosides and sodium/potassium-ATPase: three-dimensional structure-activity relationship models for ligand binding to the E2-Pi form of the enzyme versus activity inhibition.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Multiple signal transduction pathways link Na+/K+-ATPase to growth-related genes in cardiac myocytes. The roles of Ras and mitogen-activated protein kinases

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Role of protein kinase C in the signal pathways that link Na+/K+-ATPase to ERK1/2

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Src-mediated inter-receptor cross-talk between the Na+/K+-ATPase and the epidermal growth factor receptor relays the signal from ouabain to mitogen-activated protein kinases

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Na+, K+-ATPase isozyme diversity; comparative biochemistry and physiological implications of novel functional interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Investigation of ouabain-induced anticancer effect in human androgen-independent prostate cancer PC-3 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Digitalis-induced signaling by Na+/K+-ATPase in human breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Changes in sodium pump expression dictate the effects of ouabain on cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Ouabain-like factor quantification in mammalian tissues and plasma: comparison of two independent assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Endogenous and exogenous cardiac glycosides: their roles in hypertension, salt metabolism, and cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Main results of the ouabain and adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Autophagic cell death of human pancreatic tumor cells mediated by oleandrin, a lipid-soluble cardiac glycoside.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Oleandrin-mediated inhibition of human tumor cell proliferation: importance of Na,K-ATPase alpha subunits as drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

LC/MS/MS analyses of an oleander extract for cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Anvirzel, an extract of Nerium oleander, induces cell death in human but not murine cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Contemporary use of digoxin in the management of cardiovascular disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Digoxin: clinical highlights: a review of digoxin and its use in contemporary medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Apoptosis-mediated cytotoxicity of ouabain, digoxin and proscillaridin A in the estrogen independent MDA-MB-231 breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Digoxin inhibits retinal ischemia-induced HIF-1alpha expression and ocular neovascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Digoxin inhibits blood vessel density and HIF-1a expression in castration-resistant C4-2 xenograft prostate tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Treatment of congestive heart failure--current status of use of digitoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Digitoxin as an anticancer agent with selectivity for cancer cells: possible mechanisms involved

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Cardiac glycosides as novel cancer therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Cardiac glycosides. 7. Sugar stereochemistry and cardiac glycoside activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Digitalis structure-activity relationship analyses. Conclusions from indirect binding studies with cardiac (Na+ + K+)-ATPase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Conformational factors in cardiac glycoside activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Synthesis and biological evaluation of RON-neoglycosides as tumor cytotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

A stereoselective synthesis of digitoxin and digitoxigen mono- and bisdigitoxoside from digitoxigenin via a palladium-catalyzed glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

De novo approach to 2-deoxy-beta-glycosides: asymmetric syntheses of digoxose and digitoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

De novo asymmetric synthesis of the anthrax tetrasaccharide by a palladium-catalyzed glycosylation reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

De novo asymmetric syntheses of SL0101 and its analogues via a palladium-catalyzed glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

A Direct Comparison of the Anticancer Activities of Digitoxin MeON-Neoglycosides and O-Glycosides: Oligosaccharide Chain Length-Dependent Induction of Caspase-9-Mediated Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Synthesis and Evaluation of the α-D-/α-L-Rhamnosyl and Amicetosyl Digitoxigenin Oligomers as Anti-tumor Agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Digitoxin and a synthetic monosaccharide analog inhibit cell viability in lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Synthesis and evaluation of cardiac glycoside mimics as potential anticancer drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Pegylation: a novel process for modifying pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

UNBS1450 from Calotropis procera as a regulator of signaling pathways involved in proliferation and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Identification of a novel cardenolide (2''-oxovoruscharin) from Calotropis procera and the hemisynthesis of novel derivatives displaying potent in vitro antitumor activities and high in vivo tolerance: structure-activity relationship analyses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

The cardenolide UNBS1450 is able to deactivate nuclear factor kappaB-mediated cytoprotective effects in human non-small cell lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Nucleolus and c-Myc: potential targets of cardenolide-mediated antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Cardenolide-induced lysosomal membrane permeabilization demonstrates therapeutic benefits in experimental human non-small cell lung cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Targeting the alpha 1 subunit of the sodium pump to combat glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

The digitalis-like steroid hormones: new mechanisms of action and biological significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Isolation and structure of a 20,21-epoxybufenolide series from "Ch'an Su".

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

One new bufadienolide from Chinese drug "Chan'Su".

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

New bufadienolides and C(23) steroids from the venom of Bufo bufo gargarizans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Cinobufacini, an aqueous extract from Bufo bufo gargarizans Cantor, induces apoptosis through a mitochondria-mediated pathway in human hepatocellular carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Induction of apoptosis by cinobufacini preparation through mitochondria- and Fas-mediated caspase-dependent pathways in human hepatocellular carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Bufadienolides and their antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Pilot study of huachansu in patients with hepatocellular carcinoma, nonsmall-cell lung cancer, or pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

QSAR evaluation of the Ch'an Su and related bufadienolides against the colchicine-resistant primary liver carcinoma cell line PLC/PRF/5(1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Novel cytotoxic bufadienolides derived from bufalin by microbial hydroxylation and their structure-activity relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Structure-based design and synthesis of novel potent Na+,K+ -ATPase inhibitors derived from a 5alpha,14alpha-androstane scaffold as positive inotropic compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

17 alpha-O-(aminoalkyl)oxime derivatives of 3 beta,14 beta-dihydroxy-5 beta-androstane and 3 beta-hydroxy-14-oxoseco-D-5 beta-androstane as inhibitors of Na(+),K(+)-ATPase at the digitalis receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Pharmacological profile of the novel inotropic agent (E,Z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride (PST2744).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Regulation of current flow through ryanodine receptors by luminal Ca2+.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Modulation of sarcoplasmic reticulum function by Na+/K+ pump inhibitors with different toxicity: digoxin and PST2744 [(E,Z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride].

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Effects of istaroxime on diastolic stiffness in acute heart failure syndromes: results from the Hemodynamic, Echocardiographic, and Neurohormonal Effects of Istaroxime, a Novel Intravenous Inotropic and Lusitropic Agent: a Randomized Controlled Tria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Identification of hydroxyxanthones as Na/K-ATPase ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Chromenes from the brown alga Sargassum siliquastrum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

γ-Tocotrienol induces growth arrest through a novel pathway with TGFβ2 in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Sargachromanols as inhibitors of Na+/K+ ATPase and isocitrate lyase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Sarcochromenol sulfates A-C and sarcohydroquinone sulfates A-C, new natural products from the sponge Sarcotragus spinulosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Psoralidin, an herbal molecule, inhibits phosphatidylinositol 3-kinase-mediated Akt signaling in androgen-independent prostate cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Antioxidant 2-phenylbenzofurans and a coumestan from Lespedeza virgata

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

2-Methoxy-3,8,9-trihydroxy coumestan: a new synthetic inhibitor of Na+,K+-ATPase with an original mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Insights into the mechanism of Na+,K+-ATPase inhibition by 2-methoxy-3,8,9-trihydroxy coumestan

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Study on cardioactive effects of brazilein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Iantherans A and B, unique dimeric polybrominated benzofurans as Na,K-ATPase inhibitors from a marine sponge, Ianthella sp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Aplysiallene, a new bromoallene as an Na, K-ATPase inhibitor from the sea hare, Aplysia kurodai

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Salvianolic acids: small compounds with multiple mechanisms for cardiovascular protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Magnesium lithospermate B possesses inhibitory activity on Na+,K+-ATPase and neuroprotective effects against ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Magnesium lithospermate B extracted from Salvia miltiorrhiza elevates intracellular Ca(2+) level in SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Active ingredients in Chinese medicines promoting blood circulation as Na+/K+ -ATPase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

Bufadienolides of plant and animal origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

The protective effect of magnesium lithospermate B against glucose-induced intracellular oxidative damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2012.690033

10.1517/13543776.2012.690033

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference