(Q38011249)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22607384%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

title

Preclinical development of TLR ligands as drugs for the treatment of chronic viral infections (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22607384%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

0 references

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22607384%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Joerg F. Schlaak

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22607384%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

5

Ulf Dittmer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22607384%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

author name string

Xiaoyong Zhang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22607384%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Anke Kraft

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22607384%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Mengji Lu

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22607384%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

language of work or name

English

0 references

publication date

19 May 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22607384%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Drug Discovery

1 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22607384%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22607384%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22607384%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

page(s)

597-611

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22607384%20AND%20SRC:MED&resulttype=core&format=json

How the immune system works to protect the host from infection: a personal view

1 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Intrinsic antiviral immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Hepatitis B virus immunopathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Pathogenesis, natural history, treatment, and prevention of hepatitis C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Pathogen recognition and innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Innate immune responses to microbial poisons: discovery and function of the Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Structure and function of Toll receptors and their ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Cell culture and animal models of viral hepatitis. Part I: hepatitis B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Animal model for study of human hepatitis viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Small animal model systems for studying hepatitis B virus replication and pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

New animal models for hepatitis C viral infection and pathogenesis studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

HCV animal models: a journey of more than 30 years

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

In vitro replication models for the hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Immunodeficiency lentiviral infections in natural and non-natural hosts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

HIV reservoirs and latency models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Primary cell models of HIV latency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Toll-like receptors in the induction of the innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Signaling pathways downstream of pattern-recognition receptors and their cross talk

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Toll-like receptor signaling in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Toll-like receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Social and environmental risk factors in the emergence of infectious diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Hepatitis B Virus Infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Induction of a Striking Systemic Cytokine Cascade prior to Peak Viremia in Acute Human Immunodeficiency Virus Type 1 Infection, in Contrast to More Modest and Delayed Responses in Acute Hepatitis B and C Virus Infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Genomic analysis of the host response to hepatitis B virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Innate antiviral immune responses to hepatitis B virus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Control of hepatitis B virus replication by innate response of HepaRG cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Regulation of Toll-like receptor-2 expression in chronic hepatitis B by the precore protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

The hepatitis B e antigen (HBeAg) targets and suppresses activation of the toll-like receptor signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Hepatitis B virus polymerase blocks pattern recognition receptor signaling via interaction with DDX3: implications for immune evasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Epidemiology of hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

DNA microarray analysis of chimpanzee liver during acute resolving hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Interferon-alpha inhibits hepatitis C virus subgenomic RNA replication by an MxA-independent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Toll-Like Receptor 3 Mediates Establishment of an Antiviral State against Hepatitis C Virus in Hepatoma Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Activation of anti-hepatitis C virus responses via Toll-like receptor 7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

A Toll-like receptor 7 single nucleotide polymorphism protects from advanced inflammation and fibrosis in male patients with chronic HCV-infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

MyD88-dependent immune activation mediated by human immunodeficiency virus type 1-encoded Toll-like receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Gaining a foothold: how HIV avoids innate immune recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

The SET complex acts as a barrier to autointegration of HIV-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Characterization of the innate immune signalling pathways in hepatocyte cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Lipopolysaccharide-induced innate immune responses in primary hepatocytes downregulates woodchuck hepatitis virus replication via interferon-independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Stimulation of the interleukin-1 receptor and Toll-like receptor 2 inhibits hepatitis B virus replication in hepatoma cell lines in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Activation of pattern recognition receptor-mediated innate immunity inhibits the replication of hepatitis B virus in human hepatocyte-derived cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Inhibition of hepatitis B virus replication by MyD88 involves accelerated degradation of pregenomic RNA and nuclear retention of pre-S/S RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Woodchuck gamma interferon upregulates major histocompatibility complex class I transcription but is unable to deplete woodchuck hepatitis virus replication intermediates and RNAs in persistently infected woodchuck primary hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Toll-like receptor signaling inhibits hepatitis B virus replication in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Toll-like receptor 4 plays an anti-HBV role in a murine model of acute hepatitis B virus expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Current and future drugs targeting one class of innate immunity receptors: the Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Enhancement of antigen-specific immunity via the TLR4 ligands MPL adjuvant and Ribi.529.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

A review of the role of CpG oligodeoxynucleotides as toll-like receptor 9 agonists in prophylactic and therapeutic vaccine development in infectious diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Hepatitis B surface antigen-1018 ISS adjuvant-containing vaccine: a review of HEPLISAV™ safety and efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Complete replication of hepatitis C virus in cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Toll-like receptor-stimulated non-parenchymal liver cells can regulate hepatitis C virus replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Toll-like receptor activated human and murine hepatic stellate cells are potent regulators of hepatitis C virus replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Repopulation of adult and neonatal mice with human hepatocytes: a chimeric animal model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Hepatitis C virus replication in mice with chimeric human livers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Oral resiquimod in chronic HCV infection: safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Use of modelling and simulation techniques to support decision making on the progression of PF-04878691, a TLR7 agonist being developed for hepatitis C

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Intrahepatic gene expression during chronic hepatitis C virus infection in chimpanzees

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

New antiviral pathway that mediates hepatitis C virus replicon interferon sensitivity through ADAR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Fascination with 2-5A-Dependent RNase: A Unique Enzyme That Functions in Interferon Action*

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Viral stress-inducible protein p56 inhibits translation by blocking the interaction of eIF3 with the ternary complex eIF2.GTP.Met-tRNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Single nucleotide polymorphism of the MxA gene promoter influences the response to interferon monotherapy in patients with hepatitis C viral infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Expression of Toll-like receptors in chronic hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Direct stimulation of human T cells via TLR5 and TLR7/8: flagellin and R-848 up-regulate proliferation and IFN-gamma production by memory CD4+ T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

TLR7/8 triggering exerts opposing effects in acute versus latent HIV infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

TLR8 activates HIV from latently infected cells of myeloid-monocytic origin directly via the MAPK pathway and from latently infected CD4+ T cells indirectly via TNF-α.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

CpG oligodeoxynucleotides activate HIV replication in latently infected human T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Double-stranded RNA analog poly(I:C) inhibits human immunodeficiency virus amplification in dendritic cells via type I interferon-mediated activation of APOBEC3G.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Preinfection treatment of resistant mice with CpG oligodeoxynucleotides renders them susceptible to friend retrovirus-induced leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

The Toll-like receptor 7 (TLR7) agonist, imiquimod, and the TLR9 agonist, CpG ODN, induce antiviral cytokines and chemokines but do not prevent vaginal transmission of simian immunodeficiency virus when applied intravaginally to rhesus macaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Antiinfective applications of toll-like receptor 9 agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Effective postexposure treatment of retrovirus-induced disease with immunostimulatory DNA containing CpG motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

CpG-C immunostimulatory oligodeoxyribonucleotide activation of plasmacytoid dendritic cells in rhesus macaques to augment the activation of IFN-gamma-secreting simian immunodeficiency virus-specific T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

CpG-C ISS-ODN activation of blood-derived B cells from healthy and chronic immunodeficiency virus-infected macaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

A tonsillar PolyICLC/AT-2 SIV therapeutic vaccine maintains low viremia following antiretroviral therapy cessation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Enhanced antibody responses elicited by a CpG adjuvant do not improve the protective effect of an aldrithiol-2-inactivated simian immunodeficiency virus therapeutic AIDS vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

An immunocompetent mouse model for the tolerance of human chronic hepatitis B virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Hepatitis B virus core antigen determines viral persistence in a C57BL/6 mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

A genetically humanized mouse model for hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

The utility of the new generation of humanized mice to study HIV-1 infection: transmission, prevention, pathogenesis, and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

Toll-like receptor-mediated control of HBV replication by nonparenchymal liver cells in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2012.689281

10.1517/17460441.2012.689281

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22607384%20AND%20SRC:MED&resulttype=core&format=json

release_tu2imkkwcvc43cowdzp472wnlu

1 February 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/tu2imkkwcvc43cowdzp472wnlu

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference