(Q38012195)

27 August 2017

title

Structural, mechanistic and regulatory studies of serine palmitoyltransferase (English)

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27 August 2017

author

James Henderson Naismith

series ordinal

2

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27 August 2017

Dominic J Campopiano

4

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author name string

Jonathan Lowther

series ordinal

1

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27 August 2017

Teresa M Dunn

series ordinal

3

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27 August 2017

publication date

1 June 2012

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Biochemical Society Transactions

27 August 2017

published in

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27 August 2017

volume

40

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27 August 2017

issue

3

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27 August 2017

page(s)

547-554

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Lipid classification, structures and tools

27 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1042%2FBST20110769

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Two pathways of sphingolipid biosynthesis are separated in the yeast Pichia pastoris

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Chemical structure of glycosphingolipids isolated from Sphingomonas paucimobilis

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Structural confirmation of the dihydrosphinganine and fatty acid constituents of the dental pathogen Porphyromonas gingivalis

21 January 2018

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Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism

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A novel selective growth medium-PCR assay to isolate and detect Sphingomonas in environmental samples

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Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerations

21 January 2018

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The crystal structure of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl-CoA-condensing enzyme

21 January 2018

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Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans.

21 January 2018

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Three-dimensional structure of 2-amino-3-ketobutyrate CoA ligase from Escherichia coli complexed with a PLP-substrate intermediate: inferred reaction mechanism

21 January 2018

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Insights into the biosynthesis of the Vibrio cholerae major autoinducer CAI-1 from the crystal structure of the PLP-dependent enzyme CqsA

21 January 2018

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The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA

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A water-soluble homodimeric serine palmitoyltransferase from Sphingomonas paucimobilis EY2395T strain. Purification, characterization, cloning, and overproduction

21 January 2018

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The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis

21 January 2018

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Multifunctional role of His159in the catalytic reaction of serine palmitoyltransferase

21 January 2018

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The External Aldimine Form of Serine Palmitoyltransferase: STRUCTURAL, KINETIC, AND SPECTROSCOPIC ANALYSIS OF THE WILD-TYPE ENZYME AND HSAN1 MUTANT MIMICS

21 January 2018

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Role of a conserved arginine residue during catalysis in serine palmitoyltransferase

21 January 2018

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Structural insights into the enzymatic mechanism of serine palmitoyltransferase from Sphingobacterium multivorum

21 January 2018

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The serine palmitoyltransferase from Sphingomonas wittichii RW1: An interesting link to an unusual acyl carrier protein

21 January 2018

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21 January 2018

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Molecular characterization of membrane-associated soluble serine palmitoyltransferases from Sphingobacterium multivorum and Bdellovibrio stolpii

21 January 2018

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Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity

21 January 2018

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Purification of the serine palmitoyltransferase complex responsible for sphingoid base synthesis by using affinity peptide chromatography techniques

21 January 2018

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Membrane sphingolipids as essential molecular signals for Bacteroides survival in the intestine

21 January 2018

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Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation

21 January 2018

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A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis

21 January 2018

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Cloning and initial characterization of a new subunit for mammalian serine-palmitoyltransferase

21 January 2018

1 reference

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The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis

21 January 2018

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Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase

21 January 2018

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Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis

21 January 2018

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The topology of the Lcb1p subunit of yeast serine palmitoyltransferase

21 January 2018

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SPTLC1 is mutated in hereditary sensory neuropathy, type 1

21 January 2018

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Mutations in the yeast LCB1 and LCB2 genes, including those corresponding to the hereditary sensory neuropathy type I mutations, dominantly inactivate serine palmitoyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20110769

Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20110769

A disease-causing mutation in the active site of serine palmitoyltransferase causes catalytic promiscuity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20110769

Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids

21 January 2018

1 reference

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Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1.

21 January 2018

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Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine: a novel category of bioactive 1-deoxysphingoid bases and 1-deoxydihydroceramides biosynthesized by mammalian cell lines and animals

21 January 2018

1 reference

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Discovery of deoxyceramides and diacylglycerols as CD1b scaffold lipids among diverse groove-blocking lipids of the human CD1 system

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20110769

Serine palmitoyl-CoA transferase (SPT) deficiency and sphingolipid levels in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20110769

Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20110769

Orm family proteins mediate sphingolipid homeostasis

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110769

Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20110769

ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20110769

Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20110769

Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20110769

PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20110769

21 January 2018

Identifiers

DOI

10.1042/BST20110769

1 reference

27 August 2017

1 reference