(Q38014888)

27 August 2017

Evaluation of the Braak hypothesis: how far can it explain the pathogenesis of Parkinson's disease? (English)

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27 August 2017

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explanatory hypothesis

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Glenda Halliday

1

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Claire E Shepherd

object named as

Claire Shepherd

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3

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author name string

Heather McCann

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2

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27 August 2017

1 June 2012

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Expert Review of Neurotherapeutics: a key contribution to decision making in the treatment of neurologic and neuropsychiatric disorders

27 August 2017

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27 August 2017

12

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27 August 2017

6

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27 August 2017

673-686

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Alpha-synuclein in Lewy bodies

27 August 2017

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Alpha-synuclein is not a requisite component of synaptic boutons in the adult human central nervous system.

21 January 2018

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Alpha-synuclein and dopamine metabolism

21 January 2018

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Alpha-synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease.

21 January 2018

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Demonstration of alpha-synuclein immunoreactivity in neuronal and glial cytoplasm in normal human brain tissue using proteinase K and formic acid pretreatment

21 January 2018

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Staging of brain pathology related to sporadic Parkinson's disease

21 January 2018

1 reference

Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop

21 January 2018

1 reference

Simplified neuropathological diagnosis of dementia with Lewy bodies.

21 January 2018

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Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria

21 January 2018

1 reference

Pattern of brain destruction in Parkinson's and Alzheimer's diseases.

21 January 2018

1 reference

Amygdala pathology in Parkinson's disease

21 January 2018

1 reference

Dementia in idiopathic Parkinson's disease. A neuropathological study of 32 cases.

21 January 2018

1 reference

Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity.

21 January 2018

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Lewy bodies are located preferentially in limbic areas in diffuse Lewy body disease.

21 January 2018

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Senile dementia of Lewy body type. A clinically and neuropathologically distinct form of Lewy body dementia in the elderly

21 January 2018

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Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease.

21 January 2018

1 reference

The relationship between dementia and direct involvement of the hippocampus and amygdala in Parkinson's disease.

21 January 2018

1 reference

Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction

21 January 2018

1 reference

Patterns and stages of alpha-synucleinopathy: Relevance in a population-based cohort.

21 January 2018

1 reference

Incidental Lewy body disease: do some cases represent a preclinical stage of dementia with Lewy bodies?

21 January 2018

1 reference

Alpha-synuclein pathology in Parkinson's and Alzheimer's disease brain: incidence and topographic distribution--a pilot study

21 January 2018

1 reference

21 January 2018

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Regional distribution of alpha-synuclein pathology in unimpaired aging and Alzheimer disease

21 January 2018

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Alpha-synuclein pathology does not predict extrapyramidal symptoms or dementia

21 January 2018

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Applicability of current staging/categorization of alpha-synuclein pathology and their clinical relevance

21 January 2018

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Pathologic correlates of dementia in individuals with Lewy body disease

21 January 2018

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Gray matter correlations of cognition in incident Parkinson's disease.

21 January 2018

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Clinical correlates of selective pathology in the amygdala of patients with Parkinson's disease

21 January 2018

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Brain stem pathology in Parkinson's disease: an evaluation of the Braak staging model

21 January 2018

1 reference

Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations

21 January 2018

1 reference

The brain-stem lesions in Parkinsonism

21 January 2018

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Neuropathology of the Substantia nigra

21 January 2018

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Ageing and Parkinson's disease: substantia nigra regional selectivity

21 January 2018

1 reference

Selective loss of pyramidal neurons in the pre-supplementary motor cortex in Parkinson's disease

21 January 2018

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Loss of thalamic intralaminar nuclei in progressive supranuclear palsy and Parkinson's disease: clinical and therapeutic implications

21 January 2018

1 reference

Specific A10 dopaminergic nuclei in the midbrain degenerate in Parkinson's disease.

21 January 2018

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The cholinergic system and Parkinson disease

21 January 2018

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Hypocretin (orexin) loss in Parkinson's disease.

21 January 2018

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Hypocretin (orexin) cell loss in Parkinson's disease.

21 January 2018

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Loss of brainstem serotonin- and substance P-containing neurons in Parkinson's disease.

21 January 2018

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Motor score of the Unified Parkinson Disease Rating Scale as a good predictor of Lewy body-associated neuronal loss in the substantia nigra.

21 January 2018

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Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies.

21 January 2018

1 reference

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

21 January 2018

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Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

21 January 2018

1 reference

The comparative biology of neuromelanin and lipofuscin in the human brain

21 January 2018

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A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease

21 January 2018

1 reference

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

21 January 2018

1 reference

Increased iron levels correlate with the selective nigral dopaminergic neuron degeneration in Parkinson's disease.

21 January 2018

1 reference

Selective cell death in neurodegeneration: why are some neurons spared in vulnerable regions?

21 January 2018

1 reference

Selective neuronal vulnerability in neurodegenerative diseases: from stressor thresholds to degeneration

21 January 2018

1 reference

Glia: initiators and progressors of pathology in Parkinson's disease

21 January 2018

1 reference

Neuropathology underlying clinical variability in patients with synucleinopathies

21 January 2018

1 reference

Patterns of levodopa response in Parkinson's disease: a clinico-pathological study.

21 January 2018

1 reference

Epidemiology and risk factors of dementia

21 January 2018

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Age-associated prevalence and risk factors of Lewy body pathology in a general population: the Hisayama study

21 January 2018

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Relationships between age and late progression of Parkinson's disease: a clinico-pathological study.

21 January 2018

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Dementia in Parkinson's disease: a 20-year neuropsychological study (Sydney Multicentre Study).

21 January 2018

1 reference

Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases

21 January 2018

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Differences in neuropathologic characteristics across the Lewy body dementia spectrum.

21 January 2018

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The progression of pathology in Parkinson's disease

21 January 2018

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Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?

21 January 2018

1 reference

Systematic appraisal using immunohistochemistry of brain pathology in aged and demented subjects

21 January 2018

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Lewy body pathology in normal elderly subjects

21 January 2018

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Incidental Lewy body disease: clinical comparison to a control cohort

21 January 2018

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Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects.

21 January 2018

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Alpha-synuclein pathology is highly dependent on the case selection.

21 January 2018

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Incidence and remaining lifetime risk of Parkinson disease in advanced age.

21 January 2018

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Incidental Lewy body disease and preclinical Parkinson disease

21 January 2018

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Reduced striatal tyrosine hydroxylase in incidental Lewy body disease

21 January 2018

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Pathological entity of dementia with Lewy bodies and its differentiation from Alzheimer's disease

21 January 2018

1 reference

Imaging of the dopaminergic system in differential diagnosis of dementia

21 January 2018

1 reference

The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease: a critical analysis of alpha-synuclein staging

21 January 2018

1 reference

The dorsal motor nucleus of the vagus is not an obligatory trigger site of Parkinson's disease.

21 January 2018

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A critical evaluation of the Braak staging scheme for Parkinson's disease.

21 January 2018

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Cognitive status correlates with neuropathologic stage in Parkinson disease.

21 January 2018

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In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution

21 January 2018

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The progression of pathology in longitudinally followed patients with Parkinson's disease.

21 January 2018

1 reference

The epidemiology of dementia associated with Parkinson's disease

21 January 2018

1 reference

Parkinson disease neuropathology: later-developing dementia and loss of the levodopa response

21 January 2018

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Cognitive decline correlates with neuropathological stage in Parkinson's disease

21 January 2018

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Lewy body cortical involvement may not always predict dementia in Parkinson's disease

21 January 2018

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Premotor Parkinson's disease: clinical features and detection strategies

21 January 2018

1 reference

Diagnosis and the premotor phase of Parkinson disease

21 January 2018

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A critical appraisal of the premotor symptoms of Parkinson's disease: potential usefulness in early diagnosis and design of neuroprotective trials

21 January 2018

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Progress in defining the premotor phase of Parkinson's disease

21 January 2018

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REM sleep behavior disorder: from dreams to neurodegeneration

21 January 2018

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Changing demographics in REM sleep behavior disorder: possible effect of autoimmunity and antidepressants.

21 January 2018

1 reference

Serial dopamine transporter imaging of nigrostriatal function in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study.

21 January 2018

1 reference

REM sleep behavior disorder preceding other aspects of synucleinopathies by up to half a century

21 January 2018

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Neuropsychological functioning in Parkinson's disease: differential relationships with self-reported sleep-wake disturbances.

21 January 2018

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Mild cognitive impairment in rapid eye movement sleep behavior disorder and Parkinson's disease.

21 January 2018

1 reference

Is REM sleep behaviour disorder (RBD) a risk factor of dementia in idiopathic Parkinson's disease?

21 January 2018

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REM sleep behavior disorder predicts cognitive impairment in Parkinson disease without dementia.

21 January 2018

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REM behavior disorder, hallucinations and cognitive impairment in Parkinson's disease: a two-year follow up.

21 January 2018

1 reference

Cognitive performance in REM sleep behaviour disorder: a possible early marker of neurodegenerative disease?

21 January 2018

1 reference

REM sleep behavior disorder, hallucinations, and cognitive impairment in Parkinson's disease.

21 January 2018

1 reference

Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease

21 January 2018

1 reference

Low sensitivity in clinical diagnoses of dementia with Lewy bodies

21 January 2018

1 reference

Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies

21 January 2018

1 reference

The Alzheimer's disease neuroimaging initiative: progress report and future plans

21 January 2018

1 reference

In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease

21 January 2018

1 reference

Microglial activation and dopamine terminal loss in early Parkinson's disease

21 January 2018

1 reference

[11C]-PK11195 PET: quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease?

21 January 2018

1 reference

Are synucleinopathies prion-like disorders?

21 January 2018

1 reference

Prion-like transmission of protein aggregates in neurodegenerative diseases

21 January 2018

1 reference

Generalization of the prion hypothesis to other neurodegenerative diseases: an imperfect fit.

21 January 2018

1 reference

Pros and cons of a prion-like pathogenesis in Parkinson's disease

21 January 2018

1 reference

Cell-to-cell transmission of non-prion protein aggregates.

21 January 2018

1 reference

Research in motion: the enigma of Parkinson's disease pathology spread

21 January 2018

1 reference

Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen

21 January 2018

1 reference

Protein aggregate spreading in neurodegenerative diseases: problems and perspectives

21 January 2018

1 reference

Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium

21 January 2018

1 reference

Dementia with Lewy bodies: clustering of Lewy bodies in human patients.

21 January 2018

1 reference

21 January 2018

1 reference

Survival and mortality differences between dementia with Lewy bodies vs Alzheimer disease.

21 January 2018

1 reference

Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease

21 January 2018

1 reference

Evidence in favor of Braak staging of Parkinson's disease.

21 January 2018

1 reference

18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1586/ERN.12.47

1 reference

27 August 2017

1 reference

PubMed ID

22650170