(Q38016227)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22668241%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

title

Valproic acid for the treatment of malignant gliomas: review of the preclinical rationale and published clinical results (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22668241%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22668241%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

Filip Y F L de Vos

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22668241%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

author name string

Sharon Berendsen

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22668241%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

Marike Broekman

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22668241%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

Tatjana Seute

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22668241%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

Corine van Es

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22668241%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

Luca Regli

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22668241%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

Pierre Robe

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22668241%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

language of work or name

English

0 references

publication date

6 June 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22668241%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Investigational Drugs

3 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22668241%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

volume

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22668241%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22668241%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

page(s)

1391-1415

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22668241%20AND%20SRC:MED&resulttype=core&format=json

Valproic acid as epigenetic cancer drug: preclinical, clinical and transcriptional effects on solid tumors

3 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Stat3 dimerization regulated by reversible acetylation of a single lysine residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

HDAC3 influences phosphorylation of STAT3 at serine 727 by interacting with PP2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Epigenetic mechanisms in glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

NFKBIA deletion in glioblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Expression of nuclear receptor corepressors and class I histone deacetylases in astrocytic gliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

CD81, a cell cycle regulator, is a novel target for histone deacetylase inhibition in glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Vorinostat enhances the cytotoxic effects of the topoisomerase I inhibitor SN38 in glioblastoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Modulation of radiation response by histone deacetylase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Phase 1 study of valproic acid in pediatric patients with refractory solid or CNS tumors: a children's oncology group report

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Histone deacetylase inhibitors and genomic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Inside HDAC with HDAC inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

HDAC2 regulates chromatin plasticity and enhances DNA vulnerability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

HDAC inhibitor, valproic acid, induces p53-dependent radiosensitization of colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Differential expression of 12 histone deacetylase (HDAC) genes in astrocytomas and normal brain tissue: class II and IV are hypoexpressed in glioblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Histone deacetylase inhibitors: biology and mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Physiological roles of class I HDAC complex and histone demethylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Selective repression of YKL-40 by NF-kappaB in glioma cell lines involves recruitment of histone deacetylase-1 and -2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

BNIP3 (Bcl-2 19 kDa interacting protein) acts as transcriptional repressor of apoptosis-inducing factor expression preventing cell death in human malignant gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

The tale of protein lysine acetylation in the cytoplasm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Lysine acetylation targets protein complexes and co-regulates major cellular functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Acetylation and deacetylation of non-histone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Transfection with anti-p65 intrabody suppresses invasion and angiogenesis in glioma cells by blocking nuclear factor-kappaB transcriptional activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Global histone modification patterns as prognostic markers to classify glioma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

An integrated genomic analysis of human glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Antiepileptic drugs--calcium current interaction in cultured human neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Mechanisms of action of valproate: a commentatory

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Valproic acid induces differentiation and inhibition of proliferation in neural progenitor cells via the beta-catenin-Ras-ERK-p21Cip/WAF1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Histone deacetylase is a target of valproic acid-mediated cellular differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Valproic acid induces polarization, neuronal-like differentiation of a subpopulation of C6 glioma cells and selectively regulates transgene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Valproic acid induces p21 and topoisomerase-II (alpha/beta) expression and synergistically enhances etoposide cytotoxicity in human glioblastoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Phase II trial of vorinostat in recurrent glioblastoma multiforme: a north central cancer treatment group study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

A phase I/II trial of the histone deacetylase inhibitor romidepsin for adults with recurrent malignant glioma: North American Brain Tumor Consortium Study 03-03.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Active DNA demethylation: many roads lead to Rome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Epigenetic regulation of DNA methyltransferases: DNMT1 and DNMT3B in gliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

DNA methyltransferase-mediated transcriptional silencing in malignant glioma: a combined whole-genome microarray and promoter array analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Valproate and amitriptyline exert common and divergent influences on global and gene promoter-specific chromatin modifications in rat primary astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

O6-methylguanine-DNA methyltransferase is downregulated in transformed astrocyte cells: implications for anti-glioma therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

MGMT gene silencing and benefit from temozolomide in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Microarray analysis of rat brain gene expression after chronic administration of sodium valproate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Down-regulation of GluK2 kainate receptor expression by chronic treatment with mood-stabilizing anti-convulsants or lithium in cultured astrocytes and brain, but not in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Antileukemic activity of valproic acid in chronic lymphocytic leukemia B cells defined by microarray analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Gamma-aminobutyric acid inhibits synergistic interleukin-6 release but not transcriptional activation in astrocytoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

IL-6 promotion of glioblastoma cell invasion and angiogenesis in U251 and T98G cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Metabolic enzymes as oncogenes or tumor suppressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Expression of T-type calcium channel splice variants in human glioma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Is there a role for T-type Ca2+ channel in glioma cell proliferation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Variation of T-type calcium channel protein expression affects cell division of cultured tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Demethylation of Specific Wnt/β‐Catenin Pathway Genes and its Upregulation in Rat Brain Induced by Prenatal Valproate Exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Notch1 promotes glioma cell migration and invasion by stimulating β-catenin and NF-κB signaling via AKT activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Indirubins decrease glioma invasion by blocking migratory phenotypes in both the tumor and stromal endothelial cell compartments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Location, location, location: FoxM1 mediates β-catenin nuclear translocation and promotes glioma tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Wnt activation is implicated in glioblastoma radioresistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-kappaB, and glucose regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

GSK3beta regulates differentiation and growth arrest in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Potential therapeutic effect of glycogen synthase kinase 3beta inhibition against human glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Postradiation sensitization of the histone deacetylase inhibitor valproic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Autophagy induced by valproic acid is associated with oxidative stress in glioma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Enhancement of temozolomide-induced apoptosis by valproic acid in human glioma cell lines through redox regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Antiproliferative action of valproate is associated with aberrant expression and nuclear translocation of cyclin D3 during the C6 glioma G1 phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

A phosphorylation switch regulates the transcriptional activation of cell cycle regulator p21 by histone deacetylase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Phosphorylation of p21 in G2/M promotes cyclin B-Cdc2 kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Involvement of the interaction between p21 and proliferating cell nuclear antigen for the maintenance of G2/M arrest after DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Sodium valproate inhibits production of TNF-alpha and IL-6 and activation of NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

High class I HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Valproic acid exhibits biphasic effects on apoptotic cell death of activated lymphocytes through differential modulation of multiple signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Inhibition of transcription factor STAT5b suppresses proliferation, induces G1 cell cycle arrest and reduces tumor cell invasion in human glioblastoma multiforme cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

The histone deacetylase inhibitor valproic acid lessens NK cell action against oncolytic virus-infected glioblastoma cells by inhibition of STAT5/T-BET signaling and generation of gamma interferon

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Cell type-specific anti-cancer properties of valproic acid: independent effects on HDAC activity and Erk1/2 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Small molecule GSK-3 inhibitors increase neurogenesis of human neural progenitor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

GSK-3 activity in neocortical cells is inhibited by lithium but not carbamazepine or valproic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Valproic acid was well tolerated in heavily pretreated pediatric patients with high-grade glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Histone deacetylase inhibitors promote neurosteroid-mediated cell differentiation and enhance serotonin-stimulated brain-derived neurotrophic factor gene expression in rat C6 glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Promoter hypomethylation regulates CD133 expression in human gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Effects of valproic acid on the cell cycle and apoptosis through acetylation of histone and tubulin in a scirrhous gastric cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Mechanisms of synergistic antileukemic interactions between valproic acid and cytarabine in pediatric acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Histone deacetylase inhibitors downregulate checkpoint kinase 1 expression to induce cell death in non-small cell lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

HDAC inhibitors act with 5-aza-2'-deoxycytidine to inhibit cell proliferation by suppressing removal of incorporated abases in lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Valproic acid increases the in vitro effects of nitrosureas on human glioma cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Evolving anticancer drug valproic acid: insights into the mechanism and clinical studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Valproic acid inhibits angiogenesis in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Antiangiogenic therapies for high-grade glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Modulation of angiogenesis-related protein synthesis by valproic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Chronic administration of valproic acid inhibits PC3 cell growth by suppressing tumor angiogenesis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Targeting tumor angiogenesis with histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Possible future issues in the treatment of glioblastomas: special emphasis on cell migration and the resistance of migrating glioblastoma cells to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Radiation enhances the invasive potential of primary glioblastoma cells via activation of the Rho signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Human glioblastoma‐initiating cells invade specifically the subventricular zones and olfactory bulbs of mice after striatal injection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Sensing invasion: cell surface receptors driving spreading of glioblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

The extracellular space and matrix of gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Suberoylanilide hydroxamic acid limits migration and invasion of glioma cells in two and three dimensional culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Making a tumour's bed: glioblastoma stem cells and the vascular niche.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

The brain tumor microenvironment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Microglia stimulate the invasiveness of glioma cells by increasing the activity of metalloprotease-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Reciprocal effects of conditioned medium on cultured glioma cells and neural stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Bone morphogenetic protein-7 release from endogenous neural precursor cells suppresses the tumourigenicity of stem-like glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Valproic acid inhibits neural progenitor cell death by activation of NF-κB signaling pathway and up-regulation of Bcl-XL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Histone deacetylase inhibitors suppress the expression of inflammatory and innate immune response genes in human microglia and astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Valproic acid is not a substrate for P-glycoprotein or multidrug resistance proteins 1 and 2 in a number of in vitro and in vivo transport assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Exploring the possible interaction between anti-epilepsy drugs and multidrug efflux pumps; in vitro observations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Valproic acid inhibits proliferation and induces apoptosis in acute myeloid leukemia cells expressing P-gp and MRP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

A multiple-loop, double-cube microarray design applied to prostate cancer cell lines with variable sensitivity to histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Over-expression of clusterin is a resistance factor to the anti-cancer effect of histone deacetylase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Adenomatous polyposis coli determines sensitivity to histone deacetylase inhibitor-induced apoptosis in colon cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

gammaH2AX foci form preferentially in euchromatin after ionising-radiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Combination of sapacitabine and HDAC inhibitors stimulates cell death in AML and other tumour types

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Antitumor effect of suberoylanilide hydroxamic acid and topotecan in renal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Anticonvulsant drugs fail to modulate chemotherapy-induced cytotoxicity and growth inhibition of human malignant glioma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Enhanced radiation-induced cell killing and prolongation of gammaH2AX foci expression by the histone deacetylase inhibitor MS-275.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Radiation-induced chromosome aberrations in human euchromatic (17cen-p53) and heterochromatic (1cen-1q12) regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Role of cell cycle in mediating sensitivity to radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Valproic acid sensitizes human glioma cells for temozolomide and γ-radiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Inhibition of histone deacetylation: a strategy for tumor radiosensitization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

DNA repair targeting and radiotherapy: a focus on the therapeutic ratio

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Regulation of DNA double-strand break repair pathway choice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Grand rounds at the National Institutes of Health: HDAC inhibitors as radiation modifiers, from bench to clinic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Histone Deacetylase Inhibitors Augment Antitumor Efficacy of Herpes-based Oncolytic Viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

HDAC inhibitor valproic acid enhances tumor cell kill in adenovirus-HSVtk mediated suicide gene therapy in HNSCC xenograft mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Sodium valproate: monotherapy and polytherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

L-carnitine for acute valproic acid overdose: a systematic review of published cases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Anticonvulsant use during lactation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Comparison of valproate concentrations in human plasma, CSF and brain tissue after administration of different formulations of valproate or valpromide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Transport of valproate at intestinal epithelial (Caco-2) and brain endothelial (RBE4) cells: mechanism and substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Expression of monocarboxylate transporter MCT1 in normal and neoplastic human CNS tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Valproic acid and warfarin: an underrecognized drug interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Influence of enzyme-inducing antiepileptic drugs on trough level of imatinib in glioblastoma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Nitroso-urea-cisplatin-based chemotherapy associated with valproate: increase of haematologic toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

P450 enzyme inducing and non-enzyme inducing antiepileptics in glioblastoma patients treated with standard chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Drug interactions between chemotherapeutic regimens and antiepileptics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Valproic acid (VPA) in patients with refractory advanced cancer: a dose escalating phase I clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

High incidence of vaproate-induced coagulation disorders in children receiving valproic acid: a prospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

The effect of antiepileptic drugs on coagulation and bleeding in the perioperative period of epilepsy surgery: the Cleveland Clinic experience

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Absence of bleeding complications in patients undergoing cortical surgery while receiving valproate treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Quantitative assessment of postoperative blood collection in brain tumor surgery under valproate medication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Intensive chemotherapy improves survival in pediatric high-grade glioma after gross total resection: results of the HIT-GBM-C protocol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Hematologic toxicity of sodium valproate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Anticonvulsant usage is associated with an increased risk of procarbazine hypersensitivity reactions in patients with brain tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Pancreatitis associated with valproic acid: a review of the literature

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Effect of L-carnitine treatment for valproate-induced hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Valproic acid treatment of glioblastoma multiforme in a child

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Sorafenib plus valproic acid for infant spinal glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Efficacy of anti-epileptic drugs in patients with gliomas and seizures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Prolonged survival with valproic acid use in the EORTC/NCIC temozolomide trial for glioblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

Cerebral radiation necrosis: incidence, outcomes, and risk factors with emphasis on radiation parameters and chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

[HIT-GBM: multicenter study of treatment of children with malignant glioma]

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2012.694425

10.1517/13543784.2012.694425

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22668241%20AND%20SRC:MED&resulttype=core&format=json

release_hkwffxfwqvgy7colxpboq6ifme

3 February 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/hkwffxfwqvgy7colxpboq6ifme

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference