(Q39825708)

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Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19597472%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8 (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19597472%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

8

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Europe PubMed Central

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2 February 2020

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19597472%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Klaus-Michael Debatin

7

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19597472%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Stefan Rutkowski

5

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S Rutkowski

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Europe PubMed Central

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2 February 2020

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S Häcker

1

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2 February 2020

A Dittrich

2

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2 February 2020

T Schweitzer

4

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19597472%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

J Krauss

6

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2 February 2020

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13 July 2009

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2 February 2020

1 reference

Europe PubMed Central

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2 February 2020

28

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2 February 2020

35

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2 February 2020

3097-3110

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2 February 2020

The Bcl-2 apoptotic switch in cancer development and therapy

1 reference

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31 March 2020

Targeting the extrinsic apoptosis pathway in cancer

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To kill a tumor cell: the potential of proapoptotic receptor agonists

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Expression and methylation of CASP8 in neuroblastoma: identification of a promoter region

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Anti-tumor mechanisms of valproate: a novel role for an old drug

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Anticancer activities of histone deacetylase inhibitors

1 reference

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IFNgamma sensitizes for apoptosis by upregulating caspase-8 expression through the Stat1 pathway.

1 reference

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31 March 2020

5-Aza-2'-deoxycytidine and IFN-gamma cooperate to sensitize for TRAIL-induced apoptosis by upregulating caspase-8.

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31 March 2020

Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy

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Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer

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Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression.

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Sensitization for gamma-irradiation-induced apoptosis by second mitochondria-derived activator of caspase

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Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

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Resistance to TRAIL-induced apoptosis in primitive neuroectodermal brain tumor cells correlates with a loss of caspase-8 expression.

1 reference

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31 March 2020

Valproate as a mainstay of therapy for pediatric epilepsy

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The biochemistry of apoptosis

1 reference

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31 March 2020

Silencing of death receptor and caspase-8 expression in small cell lung carcinoma cell lines and tumors by DNA methylation.

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31 March 2020

Retinoic acid induces caspase-8 transcription via phospho-CREB and increases apoptotic responses to death stimuli in neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.161

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Interferon in oncological practice: review of interferon biology, clinical applications, and toxicities

1 reference

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31 March 2020

CD95's deadly mission in the immune system

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Mitochondrial membrane permeabilization in cell death

1 reference

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31 March 2020

Sodium butyrate and tributyrin induce in vivo growth inhibition and apoptosis in human prostate cancer

1 reference

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31 March 2020

Valproic acid induces growth arrest, apoptosis, and senescence in medulloblastomas by increasing histone hyperacetylation and regulating expression of p21Cip1, CDK4, and CMYC.

1 reference

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31 March 2020

Interferon-gamma sensitizes resistant Ewing's sarcoma cells to tumor necrosis factor apoptosis-inducing ligand-induced apoptosis by up-regulation of caspase-8 without altering chemosensitivity

1 reference

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31 March 2020

Interferon-gamma mediated up-regulation of caspase-8 sensitizes medulloblastoma cells to radio- and chemotherapy

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31 March 2020

Interferon gamma enhances the effectiveness of tumor necrosis factor-related apoptosis-inducing ligand receptor agonists in a xenograft model of Ewing's sarcoma

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31 March 2020

A novel method for the combined flow cytometric analysis of cell cycle and cytochrome c release

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Histone modifications: signalling receptors and potential elements of a heritable epigenetic code

1 reference

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31 March 2020

Defining characteristics of Types I and II apoptotic cells in response to TRAIL.

1 reference

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31 March 2020

Resistance of cultured peripheral T cells towards activation-induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death-inducing signaling complex

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.161

31 March 2020

Histone acetyltransferases

1 reference

https://api.crossref.org/works/10.1038%2FONC.2009.161

31 March 2020

Prognostic relevance of clinical and biological risk factors in childhood medulloblastoma: results of patients treated in the prospective multicenter trial HIT'91.

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Two CD95 (APO-1/Fas) signaling pathways

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Valproic Acid prolongs survival time of severe combined immunodeficient mice bearing intracerebellar orthotopic medulloblastoma xenografts

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31 March 2020

Nature's TRAIL--on a path to cancer immunotherapy

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Potentiation of neuroblastoma metastasis by loss of caspase-8.

1 reference

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Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN

1 reference

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Evaluation of IFN-gamma effects on apoptosis and gene expression in neuroblastoma--preclinical studies

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Histone Deacetylases: Unique Players in Shaping the Epigenetic Histone Code

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Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

1 reference

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Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells

1 reference

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Targeting XIAP Bypasses Bcl-2-Mediated Resistance to TRAIL and Cooperates with TRAIL to Suppress Pancreatic Cancer Growth In vitro and In vivo

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Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma.

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Caspase-2 can function upstream of bid cleavage in the TRAIL apoptosis pathway

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31 March 2020

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