(Q34147644)

31 July 2017

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title

Anti-tumor mechanisms of valproate: a novel role for an old drug (English)

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31 July 2017

2

Jindrich Cinatl

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31 July 2017

1

Roman A Blaheta

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31 July 2017

publication date

1 September 2002

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Medicinal Research Reviews

31 July 2017

published in

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31 July 2017

volume

22

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31 July 2017

issue

5

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31 July 2017

page(s)

492-511

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Mechanism of anticonvulsant action of valproate

31 July 2017

cites work

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Valproic acid and spina bifida

21 January 2018

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Therapeutic levels of sodium valproate inhibit mitotic indices in cells of neural origin

21 January 2018

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The anticonvulsant valproate teratogen restricts the glial cell cycle at a defined point in the mid-G1 phase

21 January 2018

1 reference

Effects of anticonvulsants on cell growth and enzymatic and receptor binding activity in a neuroblastoma x glioma hybrid cell culture.

21 January 2018

1 reference

Differentiation therapy of human cancer: basic science and clinical applications

21 January 2018

1 reference

Synergistic growth inhibition of prostate cancer cells by 1 alpha,25 Dihydroxyvitamin D(3) and its 19-nor-hexafluoride analogs in combination with either sodium butyrate or trichostatin A.

21 January 2018

1 reference

Retinoids in neuroblastoma therapy: distinct biological properties of 9-cis- and all-trans-retinoic acid.

21 January 2018

1 reference

Prostate cancer prevention strategies using antiproliferative or differentiating agents

21 January 2018

1 reference

Differentiating agents and nontoxic therapies

21 January 2018

1 reference

Targeted therapies for the myeloid leukaemias

21 January 2018

1 reference

Induction of differentiation and apoptosis- a possible strategy in the treatment of adult acute myelogenous leukemia

21 January 2018

1 reference

Valproic acid for the treatment of pediatric malignant glioma

21 January 2018

1 reference

Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action

21 January 2018

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Modulation of radiation response of human tumour cells by the differentiation inducers, phenylacetate and phenylbutyrate

21 January 2018

1 reference

The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth

21 January 2018

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Inhibitors of histone deacetylase as new anticancer agents

21 January 2018

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Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

21 January 2018

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Pharmacokinetics of valproic acid in patients with bipolar disorder

21 January 2018

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Contribution of receptor/G protein signaling to cell growth and transformation.

21 January 2018

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Increase in AP-1 transcription factor DNA binding activity by valproic acid

21 January 2018

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Differential effects of mood stabilizers on Fos/Jun proteins and AP-1 DNA binding activity in human neuroblastoma SH-SY5Y cells.

21 January 2018

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Valproate robustly enhances AP-1 mediated gene expression

21 January 2018

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Lithium and valproate differentially regulate brain regional expression of phosphorylated CREB and c-Fos

21 January 2018

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Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation.

21 January 2018

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Complex functions of AP-1 transcription factors in differentiation and survival of PC12 cells

21 January 2018

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Failure to express GAP-43 during neurogenesis affects cell cycle regulation and differentiation of neural precursors and stimulates apoptosis of neurons

21 January 2018

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Divergent cellular differentiation pathways during the invasive stage of cutaneous malignant melanoma progression

21 January 2018

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Extracellular-regulated kinases and phosphatidylinositol 3-kinase are involved in brain-derived neurotrophic factor-mediated survival and neuritogenesis of the neuroblastoma cell line SH-SY5Y.

21 January 2018

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Insulin-like growth factor-I-mediated neurite outgrowth in vitro requires mitogen-activated protein kinase activation.

21 January 2018

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Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells

21 January 2018

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Transport of valproate and its effects on GABA uptake in astroglial primary culture

21 January 2018

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Incorporation of [3H]valproic acid into lipids in GT1-7 neurons

21 January 2018

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Up-regulation of endothelial nitric-oxide synthase promoter by the phosphatidylinositol 3-kinase gamma /Janus kinase 2/MEK-1-dependent pathway

21 January 2018

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Lithium regulates PKC-mediated intracellular cross-talk and gene expression in the CNS in vivo

21 January 2018

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Soybean saponins inhibit cell proliferation by suppressing PKC activation and induce differentiation of HT-29 human colon adenocarcinoma cells

21 January 2018

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Protein kinase C as a drug target: implications for drug or diet prevention and treatment of cancer

21 January 2018

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Critical targets of protein kinase C in differentiation of tumour cells.

21 January 2018

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Sodium valproate inhibits production of TNF-alpha and IL-6 and activation of NF-kappaB

21 January 2018

1 reference

Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways

21 January 2018

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Molecular control of neural crest formation, migration and differentiation

21 January 2018

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Linking colorectal cancer to Wnt signaling

21 January 2018

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Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors

21 January 2018

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The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3.

21 January 2018

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Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen

21 January 2018

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Beta-catenin-histone deacetylase interactions regulate the transition of LEF1 from a transcriptional repressor to an activator

21 January 2018

1 reference

The peroxisome proliferator-activated receptors: ligands and activators

21 January 2018

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Peroxisome proliferator-activated receptor agonists.

21 January 2018

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Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

21 January 2018

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Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor

21 January 2018

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Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

21 January 2018

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mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer

21 January 2018

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Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. Homology to peroxisome proliferator-activated receptors

21 January 2018

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New molecular bioassays for the estimation of the teratogenic potency of valproic acid derivatives in vitro: activation of the peroxisomal proliferator-activated receptor (PPARdelta).

21 January 2018

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Peroxisome proliferator-activated receptor delta is a specific sensor for teratogenic valproic acid derivatives

21 January 2018

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Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis

21 January 2018

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Peroxisome proliferator-activated receptor gamma (PPARgamma) activation and its consequences in humans

21 January 2018

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Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN.

21 January 2018

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The multiple roles of PTEN in tumor suppression

21 January 2018

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PTEN, a unique tumor suppressor gene

21 January 2018

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Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells

21 January 2018

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Histone acetylation and chromatin assembly: a single escort, multiple dances?

21 January 2018

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What's up and down with histone deacetylation and transcription?

21 January 2018

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beta-estradiol stimulation of DNA synthesis requires different PKC isoforms in HepG2 and MCF7 cells

21 January 2018

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Differential responses of human neuroblastoma and glioblastoma to apoptosis

21 January 2018

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1,25-Dihydroxyvitamin D(3) stimulates activator protein-1-dependent Caco-2 cell differentiation

21 January 2018

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The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9).

21 January 2018

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Activator protein-1 transcription factor mediates bombesin-stimulated cyclooxygenase-2 expression in intestinal epithelial cells

21 January 2018

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Omega 3 but not omega 6 fatty acids inhibit AP-1 activity and cell transformation in JB6 cells

21 January 2018

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PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells

21 January 2018

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Role of the peroxisome proliferator-activated receptors (PPAR) in atherosclerosis

21 January 2018

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Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice

21 January 2018

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Activation of a human peroxisome proliferator-activated receptor by the antitumor agent phenylacetate and its analogs

21 January 2018

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Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein

21 January 2018

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Neuronal Differentiation of Neuro 2a Cells by Inhibitors of Cell Cycle Progression, Trichostatin A and Butyrolactone I

21 January 2018

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Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation

21 January 2018

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beta-catenin signaling and cancer

21 January 2018

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Cell type- and promoter-dependent modulation of the Wnt signaling pathway by sodium butyrate

21 January 2018

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Studies on the teratogen pharmacophore of valproic acid analogues: evidence of interactions at a hydrophobic centre.

21 January 2018

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Pentyl-4-yn-valproic acid enhances both spatial and avoidance learning, and attenuates age-related NCAM-mediated neuroplastic decline within the rat medial temporal lobe

21 January 2018

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Transfection of glioma cells with the neural-cell adhesion molecule NCAM: effect on glioma-cell invasion and growth in vivo

21 January 2018

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The anticonvulsant sodium valproate specifically induces the expression of a rat glial heat shock protein which is identified as the collagen type IV receptor

21 January 2018

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In vitro screening for anticonvulsant-induced teratogenesis: Drug alteration of cell adhesivity

21 January 2018

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Correlation of in vitro anti-proliferative potential with in vivo teratogenicity in a series of valproate analogues.

21 January 2018

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Segregation of the growth slowing effects of valproic acid from phenytoin and carbamazepine on lymphoid tumor cells

21 January 2018

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Identification of an AP-1-like sequence in the promoter region of calcyclin, a S-100-like gene. Enhancement of binding during retinoic acid-induced neuroblastoma cell differentiation.

21 January 2018

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TrkA induces differentiation but not apoptosis in C6-2B glioma cells.

21 January 2018

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Bone mineralization and osteoblast differentiation are negatively modulated by integrin alpha(v)beta3.

21 January 2018

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A role for the MEK/MAPK pathway in PMA-induced cell cycle arrest: modulation of megakaryocytic differentiation of K562 cells

21 January 2018

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Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase

21 January 2018

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Suppression of c-Fos gene transcription with malignant transformation of human bronchial epithelial cells

21 January 2018

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Peroxisome proliferator-activated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction

21 January 2018

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Dual function of troglitazone in ICAM-1 gene expression in human vascular endothelium

21 January 2018

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Endogenous PPAR gamma mediates anti-inflammatory activity in murine ischemia-reperfusion injury

21 January 2018

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Target genes of peroxisome proliferator-activated receptor gamma in colorectal cancer cells

21 January 2018

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Peroxisome proliferator-activated receptor gamma is induced during differentiation of colon epithelium cells.

21 January 2018

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Peroxisome proliferator-activated receptor gamma induces growth arrest and differentiation markers of human colon cancer cells.

21 January 2018

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Effects of ligand activation of peroxisome proliferator-activated receptor gamma in human prostate cancer

21 January 2018

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Peroxisome proliferator-activated receptor gamma ligand-induced growth inhibition of human hepatocellular carcinoma

21 January 2018

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Involvement of p21(WAF1/Cip1), p27(Kip1), and p18(INK4c) in troglitazone-induced cell-cycle arrest in human hepatoma cell lines

21 January 2018

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Induction of PPARgamma1 expression in human THP-1 monocytic leukemia cells by 9-cis-retinoic acid is associated with cellular growth suppression

21 January 2018

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Depudecin induces morphological reversion of transformed fibroblasts via the inhibition of histone deacetylase

21 January 2018

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Inhibitors of histone deacetylase arrest cell cycle and induce apoptosis in cervical carcinoma cells circumventing human papillomavirus oncogene expression

21 January 2018

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Histone deacetylases: a common molecular target for differentiation treatment of acute myeloid leukemias?

21 January 2018

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Apoptotic cytotoxic effects of a histone deacetylase inhibitor, FK228, on malignant lymphoid cells

21 January 2018

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Histone deacetylase inhibitor but not arsenic trioxide differentiates acute promyelocytic leukaemia cells with t(11;17) in combination with all-trans retinoic acid

21 January 2018

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Apicidin, an inhibitor of histone deacetylase, prevents H-ras-induced invasive phenotype

21 January 2018

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Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MED.10017

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31 July 2017

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