(Q38017718)

27 August 2017

title

Bioluminescent assays for ADME evaluation: dialing in CYP selectivity with luminogenic substrates (English)

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27 August 2017

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James J Cali

1

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27 August 2017

Dongping Ma

2

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27 August 2017

Monika G Wood

3

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27 August 2017

Poncho L Meisenheimer

4

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27 August 2017

Dieter H Klaubert

5

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27 August 2017

language of work or name

English

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publication date

11 June 2012

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Expert Opinion on Drug Metabolism & Toxicology

27 August 2017

published in

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27 August 2017

volume

8

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27 August 2017

issue

9

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27 August 2017

page(s)

1115-1130

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Cytochrome P450s and other enzymes in drug metabolism and toxicity

27 August 2017

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The involvement of CYP3A4 and CYP2C9 in the metabolism of 17 alpha-ethinylestradiol

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HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro

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Evaluation of luciferin-isopropyl acetal as a CYP3A4 substrate for human hepatocytes: effects of organic solvents, cytochrome P450 (P450) inhibitors, and P450 inducers.

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Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymes

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Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague-Dawley rat, minipig, and beagle dog.

21 January 2018

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Luminogenic cytochrome P450 assays

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Naphthyl- and quinolylluciferin: green and red light emitting firefly luciferin analogues

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Baseline lipophilicity relationships in human cytochromes P450 associated with drug metabolism

21 January 2018

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Bioluminescent assays for high-throughput screening

21 January 2018

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Prediction of drug metabolism: the case of cytochrome P450 2D6.

21 January 2018

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Automation and miniaturization of the bioluminescent UGT-Glo assay for screening of UDP-glucuronosyltransferase inhibition by various compounds.

21 January 2018

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CYP2C9 protein interactions with cytochrome b(5): effects on the coupling of catalysis

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The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution

21 January 2018

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21 January 2018

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21 January 2018

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Induction of Human CYP2C9 by Rifampicin, Hyperforin, and Phenobarbital Is Mediated by the Pregnane X Receptor

21 January 2018

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Cytochrome p-450 epoxygenase products contribute to attenuated vasoconstriction after chronic hypoxia

21 January 2018

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Reduction of ischemia and reperfusion-induced myocardial damage by cytochrome P450 inhibitors

21 January 2018

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CYP1A induction and human risk assessment: an evolving tale of in vitro and in vivo studies

21 January 2018

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Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1.

21 January 2018

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Preferential inducibility of CYP1A1 and CYP1A2 by TCDD: differential regulation in primary human hepatocytes versus transformed human cells

21 January 2018

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Cytochrome P450 pathways of arachidonic acid metabolism.

21 January 2018

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Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes

21 January 2018

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Induction of cyp1a1 is a nonspecific biomarker of aryl hydrocarbon receptor activation: results of large scale screening of pharmaceuticals and toxicants in vivo and in vitro

21 January 2018

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31 May 2024

https://opencitations.net/index/api/v1/citations/10.1124/MOL.106.032748

Identifiers

DOI

10.1517/17425255.2012.695345

1 reference

27 August 2017

1 reference