(Q34018308)

30 July 2017

title

Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver (English)

1 reference

30 July 2017

18

Andrew Kasarskis

1 reference

30 July 2017

Christine Suver

8

0 references

Stephen C Strom

object named as

Stephen C Strom

12

0 references

Eric E Schadt

17

object named as

Eric E Schadt

1 reference

30 July 2017

Xia Yang

1

1 reference

30 July 2017

Bin Zhang

2

1 reference

30 July 2017

Cliona Molony

3

1 reference

30 July 2017

Eugene Chudin

4

1 reference

30 July 2017

Ke Hao

5

1 reference

30 July 2017

Jun Zhu

6

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30 July 2017

Andrea Gaedigk

7

1 reference

30 July 2017

Hua Zhong

9

1 reference

30 July 2017

J Steven Leeder

10

1 reference

30 July 2017

F Peter Guengerich

11

1 reference

30 July 2017

Erin Schuetz

13

1 reference

30 July 2017

Thomas H Rushmore

14

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30 July 2017

Roger G Ulrich

15

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30 July 2017

J Greg Slatter

16

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30 July 2017

Pek Yee Lum

19

1 reference

30 July 2017

publication date

10 June 2010

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30 July 2017

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30 July 2017

volume

20

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30 July 2017

issue

8

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30 July 2017

page(s)

1020-1036

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Evidence for widespread adaptive evolution of gene expression in budding yeast

30 July 2017

cites work

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5 July 2018

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5 July 2018

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Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks

5 July 2018

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Cytochrome p-450 polymorphisms and response to clopidogrel

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Sex-specific differences in CYP450 isoforms in humans

5 July 2018

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Mapping the genetic architecture of gene expression in human liver

5 July 2018

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Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases

5 July 2018

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Retinoids induce cytochrome P450 3A4 through RXR/VDR-mediated pathway

5 July 2018

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A systems biology approach to drug discovery

5 July 2018

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Variations in DNA elucidate molecular networks that cause disease

5 July 2018

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Genetics of gene expression and its effect on disease

5 July 2018

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Interplay of pregnane X receptor with other nuclear receptors on gene regulation

5 July 2018

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Regulation of hepatocyte nuclear factor 4 alpha-mediated transcription

5 July 2018

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Defining clusters from a hierarchical cluster tree: the Dynamic Tree Cut package for R.

5 July 2018

1 reference

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Role of CYP1B1 in glaucoma

5 July 2018

1 reference

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Increasing the power to detect causal associations by combining genotypic and expression data in segregating populations

5 July 2018

1 reference

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The effect of ageing on cytochrome p450 enzymes: consequences for drug biotransformation in the elderly

5 July 2018

1 reference

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Pharmacogenetics and drug therapy in psychiatry--the role of the CYP2D6 polymorphism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Compendium of gene expression profiles comprising a baseline model of the human liver drug metabolism transcriptome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

The human cytochrome P450 sub-family: transcriptional regulation, inter-individual variation and interaction networks

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Xenobiotic receptor meets NF-kappaB, a collision in the small bowel

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Integrating genetic and network analysis to characterize genes related to mouse weight

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Mutual repression between steroid and xenobiotic receptor and NF-kappaB signaling pathways links xenobiotic metabolism and inflammation

5 July 2018

1 reference

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Tissue-specific expression and regulation of sexually dimorphic genes in mice

5 July 2018

1 reference

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Cytochromes P450--a family of proteins and scientists-understanding their relationships

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

A general framework for weighted gene co-expression network analysis

5 July 2018

1 reference

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New perspectives on the impact of cytochrome P450 3A expression for pediatric pharmacology

5 July 2018

1 reference

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Regulation of drug-metabolizing enzymes and transporters in inflammation

5 July 2018

1 reference

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Dietary flavonoids: effects on xenobiotic and carcinogen metabolism

5 July 2018

1 reference

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Cancer treatment and pharmacogenetics of cytochrome P450 enzymes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

An integrative genomics approach to infer causal associations between gene expression and disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Regulation of cytochrome P450 by posttranslational modification

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Sexual dimorphism in mammalian gene expression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Pharmacogenetics of the cytochromes P450.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

The effects of gender, age, ethnicity, and liver cirrhosis on cytochrome P450 enzyme activity in human liver microsomes and inducibility in cultured human hepatocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Genomic and non-genomic interactions of PPARalpha with xenobiotic-metabolizing enzymes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Genome sequence of the Brown Norway rat yields insights into mammalian evolution

5 July 2018

1 reference

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A missense mutation (GGC[435Gly]-->AGC[Ser]) in exon 8 of the CYP11B2 gene inherited in Japanese patients with congenital hypoaldosteronism

5 July 2018

1 reference

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Overexpression of peroxisome proliferator-activated receptor-alpha (PPARalpha)-regulated genes in liver in the absence of peroxisome proliferation in mice deficient in both L- and D-forms of enoyl-CoA hydratase/dehydrogenase enzymes of peroxisomal b

5 July 2018

1 reference

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Statistical significance for genomewide studies

5 July 2018

1 reference

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Crystal structure of human cytochrome P450 2C9 with bound warfarin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Microarray standard data set and figures of merit for comparing data processing methods and experiment designs

5 July 2018

1 reference

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‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*

5 July 2018

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Cardiovascular pharmacogenomics: current status, future prospects

5 July 2018

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The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4

5 July 2018

1 reference

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Hierarchical organization of modularity in metabolic networks

5 July 2018

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Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype

5 July 2018

1 reference

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The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Variability of cytochrome P450 1A2 activity over time in young and elderly healthy volunteers

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Repression of cytochrome P450 1A1 gene expression by oxidative stress: mechanisms and biological implications

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Developmental expression of cytochrome P450 enzymes in human liver

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Cytochrome P450 polymorphism--molecular, metabolic, and pharmacogenetic aspects. II. Participation of CYP isoenzymes in the metabolism of endogenous substances and drugs.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Developmental changes in human liver CYP2D6 expression.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Mutations in CYP1B1 cause primary congenital glaucoma by reduction of either activity or abundance of the enzyme.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

A helping hand for cytochrome p450 enzymes.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice

29 October 2018

1 reference

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Rosetta error model for gene expression analysis.

29 October 2018

1 reference

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The effect of aging on the relationship between the cytochrome P450 2C19 genotype and omeprazole pharmacokinetics

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Sexually dimorphic regulation of hepatic isoforms of human cytochrome p450 by growth hormone

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Smoking habit and genetic factors associated with lung cancer in a population highly exposed to arsenic

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

A beta-catenin-dependent pathway regulates expression of cytochrome P450 isoforms in mouse liver tumors

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Regulation of phase I and phase II steroid metabolism enzymes by PPAR alpha activators

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

An integrative genomics approach to the reconstruction of gene networks in segregating populations.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Tumor promoters as inhibitors of apoptosis in rat hepatocytes

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Sexual dimorphism of rat liver gene expression: regulatory role of growth hormone revealed by deoxyribonucleic Acid microarray analysis.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Developmental expression of human hepatic CYP2C9 and CYP2C19.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

The effect of age, sex, and rifampin administration on intestinal and hepatic cytochrome P450 3A activity

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909567

Cosegregation of a novel homozygous CYP11B1 mutation with the phenotype of non-classical congenital adrenal hyperplasia in a consanguineous family

29 October 2018

1 reference

12 December 2020

ADMET--turning chemicals into drugs

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12 December 2020

Association of cytochrome P450 induction with oxidative stress in vivo as evidenced by 3-hydroxylation of salicylate

1 reference

12 December 2020

Defining drug disposition determinants: a pharmacogenetic-pharmacokinetic strategy

1 reference

12 December 2020

The impact of acute phase response on the plasma clearance of antipyrine, theophylline, phenytoin and nifedipine in rabbits

1 reference

12 December 2020

Analyzing the functional and structural consequences of two point mutations (P94L and A368D) in the CYP11B1 gene causing congenital adrenal hyperplasia resulting from 11-hydroxylase deficiency

1 reference

12 December 2020

Molecular modelling of steroidogenic cytochromes P450 from families CYP11, CYP17, CYP19 and CYP21 based on the CYP102 crystal structure

1 reference

12 December 2020

Identifiers

DOI

10.1101/GR.103341.109

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30 July 2017

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30 July 2017

1 reference