(Q38021639)

27 August 2017

title

Targeted modification of wheat grain protein to reduce the content of celiac causing epitopes (English)

1 reference

27 August 2017

1 reference

S Rustgi

6

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author name string

C Osorio

1

1 reference

27 August 2017

N Wen

2

1 reference

27 August 2017

R Gemini

3

1 reference

27 August 2017

R Zemetra

4

1 reference

27 August 2017

D von Wettstein

5

1 reference

27 August 2017

publication date

26 June 2012

1 reference

Functional and Integrative Genomics

27 August 2017

published in

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27 August 2017

volume

12

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27 August 2017

issue

3

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27 August 2017

page(s)

417-438

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The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase

27 August 2017

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Sourdough lactobacilli and celiac disease

21 January 2018

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Fluorescence resonance energy transfer (FRET) peptides and cycloretro-inverso peptides derived from bradykinin as substrates and inhibitors of prolyl oligopeptidase

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21 January 2018

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21 January 2018

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21 January 2018

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Newly identified genetic risk variants for celiac disease related to the immune response

21 January 2018

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Tissue-mediated control of immunopathology in coeliac disease

21 January 2018

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Properties of the prolyl oligopeptidase homologue from Pyrococcus furiosus

21 January 2018

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Structural analysis of the HLA-DR, -DQ, and -DP alleles on the celiac disease-associated HLA-DR3 (DRw17) haplotype

21 January 2018

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Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease

21 January 2018

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Vacuolar processing enzyme plays an essential role in the crystalline structure of glutelin in rice seed

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Limited efficiency of prolyl-endopeptidase in the detoxification of gliadin peptides in celiac disease

21 January 2018

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Long-term follow-up of 61 coeliac patients diagnosed in childhood: evolution toward latency is possible on a normal diet

21 January 2018

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Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease

21 January 2018

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Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease

21 January 2018

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Efficient degradation of gluten by a prolyl endoprotease in a gastrointestinal model: implications for coeliac disease

21 January 2018

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Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease

21 January 2018

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T cells from celiac disease lesions recognize gliadin epitopes deamidated in situ by endogenous tissue transglutaminase

21 January 2018

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Mapping of gluten T-cell epitopes in the bread wheat ancestors: implications for celiac disease

21 January 2018

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21 January 2018

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Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma

21 January 2018

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Peptidomics of prolyl endopeptidase in the central nervous system

21 January 2018

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Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease

21 January 2018

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The safety, tolerance, pharmacokinetic and pharmacodynamic effects of single doses of AT-1001 in coeliac disease subjects: a proof of concept study

21 January 2018

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Rotavirus and celiac disease

21 January 2018

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Structural and genetical studies on the high-molecular-weight subunits of wheat glutenin : Part 1: Allelic variation in subunits amongst varieties of wheat (Triticum aestivum).

21 January 2018

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Polymeric binders suppress gliadin-induced toxicity in the intestinal epithelium

21 January 2018

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High selectivity of human tissue transglutaminase for immunoactive gliadin peptides: implications for celiac sprue

21 January 2018

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Effect of prolyl endopeptidase on digestive-resistant gliadin peptides in vivo

21 January 2018

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21 January 2018

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The prolyl oligopeptidase family

21 January 2018

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21 January 2018

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21 January 2018

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Effect of pretreatment of food gluten with prolyl endopeptidase on gluten-induced malabsorption in celiac sprue

21 January 2018

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Antigen Presentation to Celiac Lesion-Derived T Cells of a 33-Mer Gliadin Peptide Naturally Formed by Gastrointestinal Digestion

21 January 2018

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Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: importance of proline spacing and glutamine deamidation

21 January 2018

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cDNA cloning of porcine brain prolyl endopeptidase and identification of the active-site seryl residue

21 January 2018

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Highly efficient gluten degradation by lactobacilli and fungal proteases during food processing: new perspectives for celiac disease

21 January 2018

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Six new coeliac disease loci replicated in an Italian population confirm association with coeliac disease.

21 January 2018

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21 January 2018

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Mechanisms of epithelial translocation of the alpha(2)-gliadin-33mer in coeliac sprue

21 January 2018

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Current concepts of celiac disease pathogenesis

21 January 2018

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21 January 2018

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Intranasal administration of a recombinant alpha-gliadin down-regulates the immune response to wheat gliadin in DQ8 transgenic mice.

21 January 2018

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Structural basis for gluten intolerance in celiac sprue

21 January 2018

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Comparative biochemical analysis of three bacterial prolyl endopeptidases: implications for coeliac sprue.

21 January 2018

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Structural and mechanistic analysis of two prolyl endopeptidases: role of interdomain dynamics in catalysis and specificity.

21 January 2018

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Identification and analysis of multivalent proteolytically resistant peptides from gluten: implications for celiac sprue

21 January 2018

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Rational design of combination enzyme therapy for celiac sprue.

21 January 2018

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21 January 2018

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Celiac disease and transglutaminase 2: a model for posttranslational modification of antigens and HLA association in the pathogenesis of autoimmune disorders

21 January 2018

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Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer

21 January 2018

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Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study

21 January 2018

1 reference

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Highly efficient gluten degradation with a newly identified prolyl endoprotease: implications for celiac disease

21 January 2018

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Large-scale characterization of natural ligands explains the unique gluten-binding properties of HLA-DQ2.

21 January 2018

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Analysis and clinical effects of gluten in coeliac disease

21 January 2018

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Inactivation of prolyl endopeptidase by a peptidylchloromethane. Kinetics of inactivation and identification of sites of modification

21 January 2018

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Concerted structural changes in the peptidase and the propeller domains of prolyl oligopeptidase are required for substrate binding

21 January 2018

1 reference

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Combination of snap freezing, differential pH two-dimensional reverse-phase high-performance liquid chromatography, and iTRAQ technology for the peptidomic analysis of the effect of prolyl oligopeptidase inhibition in the rat brain.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10142-012-0287-Y

Celiac disease: how complicated can it get?

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10142-012-0287-Y

HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease

21 January 2018

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Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10142-012-0287-Y

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling

21 January 2018

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Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

21 January 2018

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Comprehensive, quantitative mapping of T cell epitopes in gluten in celiac disease.

21 January 2018

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The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides

21 January 2018

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Specificity of tissue transglutaminase explains cereal toxicity in celiac disease

21 January 2018

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CTLA4 +49 A/G and CT60 polymorphisms in Dutch coeliac disease patients

21 January 2018

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Genetic diversity trends in twentieth century crop cultivars: a meta analysis

21 January 2018

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Removing celiac disease-related gluten proteins from bread wheat while retaining technological properties: a study with Chinese Spring deletion lines

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10142-012-0287-Y

Presence of celiac disease epitopes in modern and old hexaploid wheat varieties: wheat breeding may have contributed to increased prevalence of celiac disease

21 January 2018

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Structure and function relationship in prolyl oligopeptidase

21 January 2018

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A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10142-012-0287-Y

Alpha-gliadin genes from the A, B, and D genomes of wheat contain different sets of celiac disease epitopes

21 January 2018

1 reference

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Detailed analysis of the expression of an alpha-gliadin promoter and the deposition of alpha-gliadin protein during wheat grain development

21 January 2018

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Evolutionary relationships of the prolyl oligopeptidase family enzymes.

21 January 2018

1 reference

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Increasing prevalence and high incidence of celiac disease in elderly people: a population-based study

21 January 2018

1 reference

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Environmental factors of celiac disease: cytotoxicity of hulled wheat species Triticum monococcum, T. turgidum ssp. dicoccum and T. aestivum ssp. spelta

21 January 2018

1 reference

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From analysis of mutants to genetic engineering

21 January 2018

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Improved barley broiler feed with transgenic malt containing heat-stable (1,3-1,4)-beta-glucanase

21 January 2018

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Genetic background of celiac disease and its clinical implications

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10142-012-0287-Y

Properties and applications of microbial transglutaminase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10142-012-0287-Y

Binding of Peptides from the N-Terminal Region of α-Gliadin to the Celiac Disease-Associated HLA-DQ2 Molecule Assessed in Biochemical and T Cell Assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10142-012-0287-Y

Association study of the IL18RAP locus in three European populations with coeliac disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10142-012-0287-Y

Genetic erosion in crops: concept, research results and challenges

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10142-012-0287-Y

The MYO9B Gene Is a Strong Risk Factor for Developing Refractory Celiac Disease

21 January 2018

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Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families

21 January 2018

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Differences between the fecal microbiota of coeliac infants and healthy controls

21 January 2018

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12 December 2020

Gluten stimulation of coeliac mucosa in vitro induces activation (CD25) of lamina propria CD4+ T cells and macrophages but no crypt-cell hyperplasia

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12 December 2020

Identification of gliadin presence in pharmaceutical products: appropriateness of polyclonal antibodies for detection of gliadin and other toxic prolamins

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12 December 2020

Enzyme therapy for management of coeliac disease

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12 December 2020

Extraction, separation, and purification of wheat gluten proteins and related proteins of barley, rye, and oats

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12 December 2020

Relation between gliadin structure and coeliac toxicity

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12 December 2020

Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury

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12 December 2020

Substrate specificity of barley cysteine endoproteases EP-A and EP-B

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12 December 2020

Pathways of gliadin transport in celiac disease

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12 December 2020

Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis

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12 December 2020

Supplements of transgenic malt or grain containing (1,3-1,4)-beta-glucanase increase the nutritive value of barley-based broiler diets to that of maize

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12 December 2020

T lymphocyte recognition of a celiac disease-associated cis- or trans-encoded HLA-DQ alpha/beta-heterodimer

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12 December 2020

Intranasal administration of one alpha gliadin can downregulate the immune response to whole gliadin in mice

1 reference

12 December 2020

The small GTPase Rab5a is essential for intracellular transport of proglutelin from the Golgi apparatus to the protein storage vacuole and endosomal membrane organization in developing rice endosperm

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12 December 2020

Association of IL18RAP and CCR3 with coeliac disease in the Spanish population

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12 December 2020

Wheat genomics: present status and future prospects.

1 reference

12 December 2020

Intravenous or intranasal administration of gliadin is able to down-regulate the specific immune response in mice

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12 December 2020

Overactivity of the intestinal endocannabinoid system in celiac disease and in methotrexate-treated rats

1 reference

12 December 2020

New fluorogenic substrates for the study of secondary specificity of prolyl oligopeptidase

1 reference

12 December 2020

The HLA-DQ(alpha 1*0102, beta 1*0602) heterodimer may confer susceptibility to multiple sclerosis in the absence of the HLA-DR(alpha 1*01, beta 1*1501) heterodimer

1 reference

12 December 2020

Prediction of protein cleavage sites by the barley cysteine endoproteases EP-A and EP-B based on the kinetics of synthetic peptide hydrolysis

1 reference

12 December 2020

Peptide binding characteristics of the coeliac disease-associated DQ(alpha1*0501, beta1*0201) molecule

1 reference

12 December 2020

Natural Variation in Toxicity of Wheat: Potential for Selection of Nontoxic Varieties for Celiac Disease Patients

1 reference

12 December 2020

Design of new high-affinity peptide ligands for human leukocyte antigen-DQ2 using a positional scanning peptide library

1 reference

12 December 2020

Porcine muscle prolyl endopeptidase: limited proteolysis of tryptic peptides from hemoglobin beta-chains at prolyl and alanyl bonds

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Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity

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10.1007/S10142-012-0287-Y

Identifiers

DOI

1 reference

Dimensions Publication ID

27 August 2017

1052900137

0 references

1 reference