(Q38022258)

27 August 2017

Current relevance of pharmacogenetics in immunomodulation treatment for Crohn's disease (English)

1 reference

27 August 2017

0 references

2

Murray L Barclay

1 reference

27 August 2017

1

Rebecca L Roberts

1 reference

27 August 2017

1 October 2012

1 reference

Journal of Gastroenterology and Hepatology

27 August 2017

1 reference

27 August 2017

27

1 reference

27 August 2017

10

1 reference

27 August 2017

1546-1554

1 reference

Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy

27 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Practical recommendations for pharmacogenomics-based prescription: 2010 ESF-UB Conference on Pharmacogenetics and Pharmacogenomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Thiopurine S-methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Tracing the origin of the most common thiopurine methyltransferase (TPMT) variants: preliminary data from the patterns of haplotypic association with two CA repeats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Do the distribution patterns of polymorphisms at the thiopurine S-methyltransferase locus in sub-Saharan populations need revision? Hints from Cabinda and Mozambique

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

DNA polymorphisms in ITPA including basis of inosine triphosphatase deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Association between adverse effects under azathioprine therapy and inosine triphosphate pyrophosphatase activity in patients with chronic inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Association of inosine triphosphatase 94C>A and thiopurine S-methyltransferase deficiency with adverse events and study drop-outs under azathioprine therapy in a prospective Crohn disease study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Meta-analysis: Inosine triphosphate pyrophosphatase polymorphisms and thiopurine toxicity in the treatment of inflammatory bowel disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Correlation of genotypes for thiopurine methyltransferase and inosine triphosphate pyrophosphatase with long-term clinical outcomes in Korean patients with inflammatory bowel diseases during treatment with thiopurine drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

The human glutathione transferase alpha locus: genomic organization of the gene cluster and functional characterization of the genetic polymorphism in the hGSTA1 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Characterization of the human class Mu glutathione S-transferase gene cluster and the GSTM1 deletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Differences among allelic variants of human glutathione transferase A2-2 in the activation of azathioprine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Consequences of binding an S-adenosylmethionine analogue on the structure and dynamics of the thiopurine methyltransferase protein backbone

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Effect of acute hyperhomocysteinemia on methylation potential of erythrocytes and on DNA methylation of lymphocytes in healthy male volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Genetic variation in the MTHFR gene influences thiopurine methyltransferase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Allopurinol-thiopurine combination therapy in inflammatory bowel disease: are there genetic clues to this puzzle?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

IMPDH1 promoter mutations in a patient exhibiting azathioprine resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

The role of xanthine oxidase in thiopurine metabolism: a case report

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Functional characterization of human xanthine oxidase allelic variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Evidence for a functional genetic polymorphism of the Rho-GTPase Rac1. Implication in azathioprine response?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Transporter-mediated protection against thiopurine-induced hematopoietic toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

The cellular pharmacology of methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

An update on methotrexate pharmacogenetics in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Effect of genetic polymorphisms in the folate pathway on methotrexate therapy in rheumatic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Advances in individual prediction of methotrexate toxicity: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

The pharmacogenetics of methotrexate in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Early Australian experience with infliximab, a chimeric antibody against tumour necrosis factor-alpha, in the treatment of Crohn's disease: is its efficacy augmented by steroid-sparing immunosuppressive therapy? The Infliximab User Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Predictors of response to infliximab in patients with Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Pharmacogenetics of Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Polymorphisms in apoptosis genes predict response to infliximab therapy in luminal and fistulizing Crohn's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Association between polymorphism in IgG Fc receptor IIIa coding gene and biological response to infliximab in Crohn's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

IBD5 polymorphisms in inflammatory bowel disease: association with response to infliximab

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

ANCA pattern and LTA haplotype relationship to clinical responses to anti-TNF antibody treatment in Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Multidrug resistance 1 gene polymorphisms are not associated with inflammatory bowel disease and response to therapy in Italian patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

IgG1 heavy chain-coding gene polymorphism (G1m allotypes) and development of antibodies-to-infliximab.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Tumour necrosis factor-alpha receptor 1 and 2 polymorphisms in inflammatory bowel disease and their association with response to infliximab

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

The TNF/ADAM 17 system: implication of an ADAM 17 haplotype in the clinical response to infliximab in Crohnʼs disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Lymphotoxin alpha gene in Crohnʼs disease patients: absence of implication in the response to infliximab in a large cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

NOD2/CARD15 does not influence response to infliximab in Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Pharmacogenetic investigation of the TNF/TNF-receptor system in patients with chronic active Crohn's disease treated with infliximab

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Polymorphism in IgG Fc receptor gene FCGR3A and response to infliximab in Crohnʼs disease: a subanalysis of the ACCENT I study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Response to infliximab treatment in Crohn's disease is not associated with mutations in the CARD15 (NOD2) gene: an analysis in 534 patients from two multicenter, prospective GCP-level trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1440-1746.2012.07220.X

10.1111/J.1440-1746.2012.07220.X

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference

PubMed ID

22741564