(Q38025261)

27 August 2017

Modeling and predicting clinical efficacy for drugs targeting the tumor milieu (English)

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27 August 2017

Mallika Singh

1

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PubMed ID

22781694

27 August 2017

Napoleone Ferrara

series ordinal

2

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27 August 2017

10 July 2012

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27 August 2017

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27 August 2017

30

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27 August 2017

648-657

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27 August 2017

7

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https://scigraph.springernature.com/pub.10.1038/nbt.2286

27 August 2017

0 references

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Making the investigational oncology pipeline more efficient and effective: are we headed in the right direction?

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21 January 2018

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Phase II study of recombinant human endostatin in patients with advanced neuroendocrine tumors

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Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

21 January 2018

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Role of vascular endothelial growth factor in ovarian cancer: inhibition of ascites formation by immunoneutralization

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Sunitinib malate for the treatment of pancreatic neuroendocrine tumors

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Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis

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Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis

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Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors

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Tumor and stromal pathways mediating refractoriness/resistance to anti-angiogenic therapies

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Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

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Pericytes limit tumor cell metastasis

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Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway

21 January 2018

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Disease course patterns after discontinuation of bevacizumab: pooled analysis of randomized phase III trials

21 January 2018

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Anti-VEGF antibody treatment of glioblastoma prolongs survival but results in increased vascular cooption

21 January 2018

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Hallmarks of Cancer: The Next Generation

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Cancer immunotherapy comes of age

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Cancer and immune response: old and new evidence for future challenges.

21 January 2018

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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

21 January 2018

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Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

21 January 2018

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Immunostimulatory monoclonal antibodies for cancer therapy

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Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer

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Enhancement of antitumor immunity by CTLA-4 blockade

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Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

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Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria

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Novel cancer immunotherapy agents with survival benefit: recent successes and next steps

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Anti-CTLA-4 antibody therapy: immune monitoring during clinical development of a novel immunotherapy

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Development of ipilimumab: contribution to a new paradigm for cancer immunotherapy

21 January 2018

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Combining immunotherapy and targeted therapies in cancer treatment

21 January 2018

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Tumor stroma and regulation of cancer development

21 January 2018

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PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment

21 January 2018

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DNA damage-mediated induction of a chemoresistant niche

21 January 2018

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FcRgamma activation regulates inflammation-associated squamous carcinogenesis.

21 January 2018

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Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

21 January 2018

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Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells.

21 January 2018

1 reference

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner.

21 January 2018

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Chemotherapeutic resistance: surviving stressful situations

21 January 2018

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21 January 2018

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Modeling therapy resistance in genetically engineered mouse cancer models

21 January 2018

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Mouse models of human AML accurately predict chemotherapy response

21 January 2018

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Moderate Increase in Mdr1a/1b Expression Causes In vivo Resistance to Doxorubicin in a Mouse Model for Hereditary Breast Cancer

21 January 2018

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Erlotinib resistance in mouse models of epidermal growth factor receptor-induced lung adenocarcinoma

21 January 2018

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Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors

21 January 2018

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21 January 2018

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Bv8 regulates myeloid-cell-dependent tumour angiogenesis

21 January 2018

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Brivanib, a dual FGF/VEGF inhibitor, is active both first and second line against mouse pancreatic neuroendocrine tumors developing adaptive/evasive resistance to VEGF inhibition

21 January 2018

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21 January 2018

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Envisioning the future of early anticancer drug development.

21 January 2018

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21 January 2018

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A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

21 January 2018

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21 January 2018

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A rapid and scalable system for studying gene function in mice using conditional RNA interference

21 January 2018

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21 January 2018

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Application of a translational profiling approach for the comparative analysis of CNS cell types

21 January 2018

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A translational profiling approach for the molecular characterization of CNS cell types

21 January 2018

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Cell-type-specific isolation of ribosome-associated mRNA from complex tissues

21 January 2018

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Cancer immunotherapy--revisited

21 January 2018

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21 January 2018

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21 January 2018

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Blocking the interaction of vascular endothelial growth factor receptors with their ligands and their effector signaling as a novel therapeutic target for cancer: time for a new look?

21 January 2018

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Antiangiogenic cancer therapy: why do mouse and human patients respond in a different way to the same drug?

21 January 2018

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Sunitinib prolongs survival in genetically engineered mouse models of multistep lung carcinogenesis

21 January 2018

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Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer.

21 January 2018

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21 January 2018

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Phase II trial of bevacizumab plus gemcitabine in patients with advanced pancreatic cancer

21 January 2018

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Imaging guided trials of the angiogenesis inhibitor sunitinib in mouse models predict efficacy in pancreatic neuroendocrine but not ductal carcinoma

21 January 2018

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Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study

21 January 2018

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Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies.

21 January 2018

1 reference

12 December 2020

Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium

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12 December 2020

Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas

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12 December 2020

Accrual to cancer clinical trials in the era of molecular medicine

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12 December 2020

Human tumor xenografts as predictive preclinical models for anticancer drug activity in humans: better than commonly perceived-but they can be improved

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12 December 2020

Mechanisms of drug combinations: interaction and network perspectives

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12 December 2020

Realization of the therapeutic potential of CTLA-4 blockade in low-dose chemotherapy-treated tumor-bearing mice

1 reference

12 December 2020

A Phase I and pharmacokinetic study of TNP-470 administered weekly to patients with advanced cancer.

1 reference

12 December 2020

Rethinking the metastatic cascade as a therapeutic target

1 reference

12 December 2020

Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models

1 reference

12 December 2020

Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer models

1 reference

12 December 2020

The use of endostatin in the treatment of solid tumors

1 reference

12 December 2020

Fibroblast growth factors are required for efficient tumor angiogenesis

1 reference

12 December 2020

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

1 reference

12 December 2020

Safety, activity, and immune correlates of anti-PD-1 antibody in cancer

1 reference

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NBT.2286

1 reference

PubMed ID

22781694

Dimensions Publication ID

27 August 2017

0 references

1 reference

PubMed ID

22781694