(Q83265745)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19180105%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

review article

1 reference

title

Mechanisms of drug combinations: interaction and network perspectives (English)

1 reference

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20 January 2020

2

1 reference

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20 January 2020

author name string

Jia Jia

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19180105%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Xiaohua Ma

3

1 reference

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20 January 2020

Zhiwei Cao

4

1 reference

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20 January 2020

Zhiwei W Cao

5

1 reference

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20 January 2020

Yixue Li

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19180105%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Yixue X Li

7

1 reference

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20 January 2020

Yu Zong Chen

8

1 reference

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20 January 2020

publication date

1 February 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19180105%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Drug Discovery

20 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19180105%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19180105%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

page(s)

111-128

1 reference

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20 January 2020

issue

2

1 reference

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https://scigraph.springernature.com/pub.10.1038/nrd2683

20 January 2020

exact match

0 references

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Drug discovery: a historical perspective

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Drugs, their targets and the nature and number of drug targets

31 March 2020

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Therapeutic targets: progress of their exploration and investigation of their characteristics.

31 March 2020

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Drug repositioning: identifying and developing new uses for existing drugs

31 March 2020

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Targeted deletion of mNth1 reveals a novel DNA repair enzyme activity.

31 March 2020

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Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast.

31 March 2020

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Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases

31 March 2020

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Identifying regulatory networks by combinatorial analysis of promoter elements

31 March 2020

1 reference

Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression

31 March 2020

1 reference

Crosstalk of oncogenic and prostanoid signaling pathways

31 March 2020

1 reference

Resistance to endocrine therapy in breast cancer: exploiting estrogen receptor/growth factor signaling crosstalk

31 March 2020

1 reference

Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3

31 March 2020

1 reference

Uncoupling between epidermal growth factor receptor and downstream signals defines resistance to the antiproliferative effect of Gefitinib in bladder cancer cells

31 March 2020

1 reference

Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy.

31 March 2020

1 reference

Multicomponent therapeutics for networked systems

31 March 2020

1 reference

The efficiency of multi-target drugs: the network approach might help drug design

31 March 2020

1 reference

A robustness-based approach to systems-oriented drug design.

31 March 2020

1 reference

Why is cancer drug discovery so difficult?

31 March 2020

1 reference

Lovastatin and extended-release niacin combination product: the first drug combination for the management of hyperlipidemia

31 March 2020

1 reference

Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy

31 March 2020

1 reference

Multi-target therapeutics: when the whole is greater than the sum of the parts

31 March 2020

1 reference

Strategies for optimizing combinations of molecularly targeted anticancer agents

31 March 2020

1 reference

Multi-targeting by monotherapeutic antibacterials.

31 March 2020

1 reference

Synergistic interactions between two alpha(2)-adrenoceptor agonists, dexmedetomidine and ST-91, in two substrains of Sprague-Dawley rats.

31 March 2020

1 reference

Synergistic interactions among antifolates

31 March 2020

1 reference

Daptomycin synergy with rifampicin and ampicillin against vancomycin-resistant enterococci

31 March 2020

1 reference

Antimicrobial synergy between mRNA- and protein-level inhibitors.

31 March 2020

1 reference

The mechanism of methylselenocysteine and docetaxel synergistic activity in prostate cancer cells

31 March 2020

1 reference

Antimalarial drug synergism and antagonism: mechanistic and clinical significance.

31 March 2020

1 reference

Mechanistic basis of enzyme-targeted drugs

31 March 2020

1 reference

Investigating the molecular basis of drug action and response: chemocentric genomics and proteomics

31 March 2020

1 reference

DrugBank: a comprehensive resource for in silico drug discovery and exploration

31 March 2020

1 reference

Internet resources related to drug action and human response: a review

31 March 2020

1 reference

BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities

31 March 2020

1 reference

Internet resources for proteins associated with drug therapeutic effects, adverse reactions and ADME.

31 March 2020

1 reference

Ligand-protein inverse docking and its potential use in the computer search of protein targets of a small molecule

31 March 2020

1 reference

Recovering the true targets of specific ligands by virtual screening of the protein data bank

31 March 2020

1 reference

Robust ligand-based modeling of the biological targets of known drugs

31 March 2020

1 reference

From drug to protein: using yeast genetics for high-throughput target discovery

31 March 2020

1 reference

Bridging chemical and biological space: "target fishing" using 2D and 3D molecular descriptors

31 March 2020

1 reference

Support vector machines approach for predicting druggable proteins: recent progress in its exploration and investigation of its usefulness.

31 March 2020

1 reference

Does drug-target have a likeness?

31 March 2020

1 reference

Multipathway model enables prediction of kinase inhibitor cross-talk effects on migration of Her2-overexpressing mammary epithelial cells

31 March 2020

1 reference

Dynamical pathway analysis

31 March 2020

1 reference

Pathway analysis for design of promiscuous drugs and selective drug mixtures

31 March 2020

1 reference

Genetic variation in the cysteine biosynthesis pathway causes sensitivity to pharmacological compounds

31 March 2020

1 reference

Physical environment modulates the behavioral responses induced by chemical stimulation of dorsal periaqueductal gray in mice.

31 March 2020

1 reference

Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival

31 March 2020

1 reference

Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors.

31 March 2020

1 reference

Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

31 March 2020

1 reference

Sister-chromatid exchanges in human lymphocytes induced by dimethoate, omethoate, deltamethrin, benomyl and their mixture

31 March 2020

1 reference

Combination antifungal therapy

31 March 2020

1 reference

Nonlinear blending: a useful general concept for the assessment of combination drug synergy

31 March 2020

1 reference

Interactions between drugs and occupied receptors

31 March 2020

1 reference

Towards a mechanism-based analysis of pharmacodynamic drug-drug interactions in vivo

31 March 2020

1 reference

Basis for effective combination cancer chemotherapy with antimetabolites

31 March 2020

1 reference

Principles: mechanisms and modeling of synergism in cellular responses

31 March 2020

1 reference

Database resources of the National Center for Biotechnology Information: update

31 March 2020

1 reference

Inhibition of heat shock protein-90 modulates multiple functions required for survival of human T-cell leukemia virus type I-infected T-cell lines and adult T-cell leukemia cells

31 March 2020

1 reference

The role of DNA mismatch repair in cisplatin mutagenicity

31 March 2020

1 reference

DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

31 March 2020

1 reference

Platinated DNA adducts enhance poisoning of DNA topoisomerase I by camptothecin

31 March 2020

1 reference

DNA damage by anti-cancer agents resolved at the nucleotide level of a single copy gene: evidence for a novel binding site for cisplatin in cells

31 March 2020

1 reference

Efficiency of extension of mismatched primer termini across from cisplatin and oxaliplatin adducts by human DNA polymerases beta and eta in vitro

31 March 2020

1 reference

Antitumour drugs impede DNA uncoiling by topoisomerase I

31 March 2020

1 reference

The combination of yondelis and cisplatin is synergistic against human tumor xenografts

31 March 2020

1 reference

SV40 DNA replication inhibition by the monofunctional DNA alkylator Et743.

31 March 2020

1 reference

5-Aza-2'-deoxycytidine and depsipeptide synergistically induce expression of BIK (BCL2-interacting killer).

31 March 2020

1 reference

The HSP90 inhibitor 17-AAG synergizes with doxorubicin and U0126 in anaplastic large cell lymphoma irrespective of ALK expression

31 March 2020

1 reference

Evidence of involvement of central neural mechanisms in generating fibromyalgia pain

31 March 2020

1 reference

Synergistic and additive interactions of the cannabinoid agonist CP55,940 with mu opioid receptor and alpha2-adrenoceptor agonists in acute pain models in mice.

31 March 2020

1 reference

Taxol anticancer activity and DNA binding

31 March 2020

1 reference

Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid

31 March 2020

1 reference

The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase

31 March 2020

1 reference

Microtubules containing acetylated alpha-tubulin in mammalian cells in culture

31 March 2020

1 reference

Celecoxib inhibits interleukin-12 alphabeta and beta2 folding and secretion by a novel COX2-independent mechanism involving chaperones of the endoplasmic reticulum.

31 March 2020

1 reference

Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum

31 March 2020

1 reference

Emodin negatively affects the phosphoinositide 3-kinase/AKT signalling pathway: a study on its mechanism of action

31 March 2020

1 reference

Vancomycin acts synergistically with gentamicin against penicillin-resistant pneumococci by increasing the intracellular penetration of gentamicin

31 March 2020

1 reference

Structural origins of gentamicin antibiotic action

31 March 2020

1 reference

Rotational-echo double resonance characterization of the effects of vancomycin on cell wall synthesis in Staphylococcus aureus.

31 March 2020

1 reference

Mode of action and in-vitro activity of vancomycin

31 March 2020

1 reference

Endothelin A receptor antagonism and angiotensin-converting enzyme inhibition are synergistic via an endothelin B receptor-mediated and nitric oxide-dependent mechanism

31 March 2020

1 reference

Endothelin-A receptor antagonist-mediated vasodilatation is attenuated by inhibition of nitric oxide synthesis and by endothelin-B receptor blockade.

31 March 2020

1 reference

Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model

31 March 2020

1 reference

Effective combination of ET-743 and doxorubicin in sarcoma: preclinical studies

31 March 2020

1 reference

Identification and hydropathic characterization of structural features affecting sequence specificity for doxorubicin intercalation into DNA double-stranded polynucleotides

31 March 2020

1 reference

The inefficiency of incisions of ecteinascidin 743-DNA adducts by the UvrABC nuclease and the unique structural feature of the DNA adducts can be used to explain the repair-dependent toxicities of this antitumor agent

31 March 2020

1 reference

Platinum-intercalator conjugates: from DNA-targeted cisplatin derivatives to adenine binding complexes as potential modulators of gene regulation

31 March 2020

1 reference

Effect of theophylline and aminophylline on transmitter release at the mammalian neuromuscular junction is not mediated by cAMP

31 March 2020

1 reference

Targeting Hsp90 by 17-AAG in leukemia cells: mechanisms for synergistic and antagonistic drug combinations with arsenic trioxide and Ara-C.

31 March 2020

1 reference

Synergism between etoposide and 17-AAG in leukemia cells: critical roles for Hsp90, FLT3, topoisomerase II, Chk1, and Rad51.

31 March 2020

1 reference

Oral drug absorption enhancement by chitosan and its derivatives

31 March 2020

1 reference

Combined antibacterial activity of amoxicillin with clavulanic acid against ampicillin-resistant strains

31 March 2020

1 reference

Synergy of antibiotics against Streptomyces somaliensis isolates in vitro

31 March 2020

1 reference

Observations on the symptomatic treatment of chronic vascular headache with cafergone (ergotamine tartrate and caffeine)

31 March 2020

1 reference

Efficacy and Tolerability of Low-dose Simvastatin and Niacin, Alone and in Combination, in Patients With Combined Hyperlipidemia: A Prospective Trial

31 March 2020

1 reference

The MEK/MAPK pathway is involved in the resistance of breast cancer cells to the EGFR tyrosine kinase inhibitor gefitinib

31 March 2020

1 reference

Isobolographic analysis of interactions between intravenous morphine, propacetamol, and diclofenac in carrageenin-injected rats

31 March 2020

1 reference

Synergistic effects of fluticasone propionate and salmeterol on in vitro T-cell activation and apoptosis in asthma

31 March 2020

1 reference

Activity and interaction of trimethoprim and sulphamethoxazole against Escherichia coli

31 March 2020

1 reference

Scientific rationale for inhaled combination therapy with long-acting beta2-agonists and corticosteroids

31 March 2020

1 reference

5-fluorouracil-methotrexate synergy: enhancement of 5-fluorodeoxyridylate binding to thymidylate synthase by dihydropteroylpolyglutamates

31 March 2020

1 reference

Erythromycin, roxithromycin, and clarithromycin: use of slow-binding kinetics to compare their in vitro interaction with a bacterial ribosomal complex active in peptide bond formation

31 March 2020

1 reference

Prostaglandin-mediated control of rat brain kynurenic acid synthesis--opposite actions by COX-1 and COX-2 isoforms

31 March 2020

1 reference

Mechanism of acetaminophen inhibition of cyclooxygenase isoforms

31 March 2020

1 reference

Amoxycillin/clavulanic acid: a review of its antibacterial activity, pharmacokinetics and therapeutic use.

31 March 2020

1 reference

Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone).

31 March 2020

1 reference

Cisplatin: mode of cytotoxic action and molecular basis of resistance

31 March 2020

1 reference

Effect of caffeine on ergotamine absorption from rat small intestine

31 March 2020

1 reference

Simvastatin. A reappraisal of its pharmacology and therapeutic efficacy in hypercholesterolaemia

31 March 2020

1 reference

Epidermal growth factor receptor pathway analysis identifies amphiregulin as a key factor for cisplatin resistance of human breast cancer cells

31 March 2020

1 reference

Pathway analysis tools and toxicogenomics reference databases for risk assessment

31 March 2020

1 reference

Illuminating drug discovery with biological pathways

31 March 2020

1 reference

Advancing drug discovery through systems biology

31 March 2020

1 reference

Rational drug discovery: what can we learn from regulatory networks?

31 March 2020

1 reference

Trastuzumab: triumphs and tribulations

31 March 2020

1 reference

Remission of human breast cancer xenografts on therapy with humanized monoclonal antibody to HER-2 receptor and DNA-reactive drugs

31 March 2020

1 reference

Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling

31 March 2020

1 reference

Aplidin synergizes with cytosine arabinoside: functional relevance of mitochondria in Aplidin-induced cytotoxicity

31 March 2020

1 reference

Oncogenic pathway signatures in human cancers as a guide to targeted therapies

31 March 2020

1 reference

Acute lymphoblastic leukaemia: a model for the pharmacogenomics of cancer therapy.

31 March 2020

1 reference

A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery

31 March 2020

1 reference

Better therapeutics through microarrays

31 March 2020

1 reference

Identification of molecular mechanisms for cellular drug resistance by combining drug activity and gene expression profiles

31 March 2020

1 reference

Microarray-based identification of new targets for specific therapies in pediatric leukemia

31 March 2020

1 reference

Microarrays of 41 human tumor cell lines for the characterization of new molecular targets: expression patterns of cathepsin B and the transferrin receptor

31 March 2020

1 reference

Protein interactions with platinum-DNA adducts: from structure to function

31 March 2020

1 reference

DNA strand breaks and apoptosis induced by oxaliplatin in cancer cells

31 March 2020

1 reference

Synergistic interaction between the EGFR tyrosine kinase inhibitor gefitinib ("Iressa") and the DNA topoisomerase I inhibitor CPT-11 (irinotecan) in human colorectal cancer cells

31 March 2020

1 reference

Mechanism of synergy between epigallocatechin gallate and beta-lactams against methicillin-resistant Staphylococcus aureus

31 March 2020

1 reference

Cell wall integrity modulates RHO1 activity via the exchange factor ROM2

31 March 2020

1 reference

Taxanes: microtubule and centrosome targets, and cell cycle dependent mechanisms of action

31 March 2020

1 reference

Signal transduction pathways of taxanes-induced apoptosis

31 March 2020

1 reference

Taxol induces caspase-10-dependent apoptosis

31 March 2020

1 reference

ERK pathway mediates the activation of Cdk2 in IGF-1-induced proliferation of human osteosarcoma MG-63 cells

31 March 2020

1 reference

Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53.

31 March 2020

1 reference

Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation.

31 March 2020

1 reference

The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 (Iressa) suppresses proliferation and invasion of human oral squamous carcinoma cells via p53 independent and MMP, uPAR dependent mechanism

31 March 2020

1 reference

Taxanes in the treatment of non-small cell lung cancer

31 March 2020

1 reference

Tumor inhibitory effect of gefitinib (ZD1839, Iressa) and taxane combination therapy in EGFR-overexpressing breast cancer cell lines (MCF7/ADR, MDA-MB-231).

31 March 2020

1 reference

A MEK inhibitor, PD98059 enhances IL-1-induced NF-kappaB activation by the enhanced and sustained degradation of IkappaBalpha

31 March 2020

1 reference

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

31 March 2020

1 reference

HIV-1-specific RT inhibitors: highly selective inhibitors of human immunodeficiency virus type 1 that are specifically targeted at the viral reverse transcriptase

31 March 2020

1 reference

Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity

31 March 2020

1 reference

Inhibition of phosphorolysis catalyzed by HIV-1 reverse transcriptase is responsible for the synergy found in combinations of 3'-azido-3'-deoxythymidine with nonnucleoside inhibitors

31 March 2020

1 reference

Primer unblocking and rescue of DNA synthesis by azidothymidine (AZT)-resistant HIV-1 reverse transcriptase: comparison between initiation and elongation of reverse transcription and between (-) and (+) strand DNA synthesis

31 March 2020

1 reference

Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy

31 March 2020

1 reference

JNK activation is critical for Aplidin-induced apoptosis.

31 March 2020

1 reference

VEGF inhibition and cytotoxic effect of aplidin in leukemia cell lines and cells from acute myeloid leukemia.

31 March 2020

1 reference

Ara-C affects formation of cancer cell DNA synthesome replication intermediates

31 March 2020

1 reference

Apoptosome dysfunction in human cancer

31 March 2020

1 reference

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

31 March 2020

1 reference

The novel atypical retinoid ST1926 is active in ATRA resistant neuroblastoma cells acting by a different mechanism

31 March 2020

1 reference

Modulation of survival signaling pathways and persistence of the genotoxic stress as a basis for the synergistic interaction between the atypical retinoid ST1926 and the epidermal growth factor receptor inhibitor ZD1839.

31 March 2020

1 reference

p38 MAP kinase mediates stress-induced internalization of EGFR: implications for cancer chemotherapy

31 March 2020

1 reference

Cardiovascular effects of phosphodiesterase 5 inhibitors

31 March 2020

1 reference

Prostanoid receptors involved in the relaxation of human pulmonary vessels

31 March 2020

1 reference

Phospholipase C activation by prostacyclin receptor agonist in cerebral microvascular smooth muscle cells

31 March 2020

1 reference

Vasodilator effect and mechanism of action of vascular endothelial growth factor in skin vasculature

31 March 2020

1 reference

Novel mode of action of iloprost: in vitro down-regulation of endothelial cell adhesion molecules

31 March 2020

1 reference

Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension.

31 March 2020

1 reference

Desensitization of NO/cGMP signaling in smooth muscle: blood vessels versus airways

31 March 2020

1 reference

MaxiK channel-mediated relaxation of guinea-pig aorta following stimulation of IP receptor with beraprost via cyclic AMP-dependent and -independent mechanisms

31 March 2020

1 reference

The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects

31 March 2020

1 reference

Spinal vs. supraspinal sites of action of the alpha 2-adrenergic agonists clonidine and ST-91 on the acoustic startle reflex

31 March 2020

1 reference

Physiological significance of alpha(2)-adrenergic receptor subtype diversity: one receptor is not enough

31 March 2020

1 reference

The immunosuppressive agent mizoribine monophosphate forms a transition state analogue complex with inosine monophosphate dehydrogenase

31 March 2020

1 reference

Combination effect of mycophenolate mofetil with mizoribine on cell proliferation assays and in a mouse heart transplantation model

31 March 2020

1 reference

Mechanism of action of antitumor drugs that interact with microtubules and tubulin

31 March 2020

1 reference

Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin.

31 March 2020

1 reference

Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells

31 March 2020

1 reference

The development of combination drugs for atherosclerosis

31 March 2020

1 reference

Drug combinations in pain treatment: a review of the published evidence and a method for finding the optimal combination

31 March 2020

1 reference

Beta-lactams against methicillin-resistant Staphylococcus aureus

31 March 2020

1 reference

Daptomycin morphostructural damage in Bacillus cereus visualized by atomic force microscopy

31 March 2020

1 reference

Localization of penicillin-binding proteins to the splitting system of Staphylococcus aureus septa by using a mercury-penicillin V derivative

31 March 2020

1 reference

Angiotensin AT1 receptor antagonism and protection against cardiovascular end-organ damage.

31 March 2020

1 reference

Ramipril in the treatment of vascular diseases

31 March 2020

1 reference

Ramiprilat attenuates the local release of noradrenaline in the ischemic myocardium

31 March 2020

1 reference

Combined blockade of AT1-receptors and ACE synergistically potentiates antihypertensive effects in SHR.

31 March 2020

1 reference

Additive antinociceptive effect of the combination of diazoxide, an activator of ATP-sensitive K+ channels, and sodium nitroprusside and dibutyryl-cGMP.

31 March 2020

1 reference

Binding and effect of K ATP channel openers in the absence of Mg2+

31 March 2020

1 reference

Dibutyryl-cyclic GMP induces peripheral antinociception via activation of ATP-sensitive K(+) channels in the rat PGE2-induced hyperalgesic paw

31 March 2020

1 reference

Nitric oxide activates glibenclamide-sensitive K+ channels in urinary bladder myocytes through a c-GMP-dependent mechanism

31 March 2020

1 reference

31 March 2020

1 reference

Anaesthetic binding sites for etomidate and propofol on a GABAA receptor model.

31 March 2020

1 reference

The actions of sevoflurane and desflurane on the gamma-aminobutyric acid receptor type A: effects of TM2 mutations in the alpha and beta subunits

31 March 2020

1 reference

Interaction of propofol and sevoflurane on loss of consciousness and movement to skin incision during general anesthesia.

31 March 2020

1 reference

Mapping of the benzodiazepine recognition site on GABA(A) receptors

31 March 2020

1 reference

Mechanisms of resistance to imipenem and ampicillin in Enterococcus faecalis

31 March 2020

1 reference

The basis for resistance to beta-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus

31 March 2020

1 reference

Re-evaluation of how artemisinins work in light of emerging evidence of in vitro resistance

31 March 2020

1 reference

Cytotoxic effect of curcumin on malaria parasite Plasmodium falciparum: inhibition of histone acetylation and generation of reactive oxygen species

31 March 2020

1 reference

Curcumin-artemisinin combination therapy for malaria

31 March 2020

1 reference

In vitro activity of azithromycin in combination with amikacin, ceftazidime, ciprofloxacin or imipenem against clinical isolates of Acinobacter baumannii.

31 March 2020

1 reference

In vitro synergistic effects of double combinations of beta-lactams and azithromycin against clinical isolates of Neisseria gonorrhoeae

31 March 2020

1 reference

Ion channel behavior of amphotericin B in sterol-free and cholesterol- or ergosterol-containing supported phosphatidylcholine bilayer model membranes investigated by electrochemistry and spectroscopy

31 March 2020

1 reference

Triazole-polyene antagonism in experimental invasive pulmonary aspergillosis: in vitro and in vivo correlation

31 March 2020

1 reference

Effect of L-menthol and 1,8-cineole on phase behavior and molecular organization of SC lipids and skin permeation of zidovudine

31 March 2020

1 reference

Transdermal delivery of zidovudine: effect of terpenes and their mechanism of action

31 March 2020

1 reference

Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug inter

31 March 2020

1 reference

Effects of fibrates on metabolism of statins in human hepatocytes

31 March 2020

1 reference

Physicochemical characterization of molecular assemblies of miltefosine and amphotericin B

31 March 2020

1 reference

Interaction between miltefosine and amphotericin B: consequences for their activities towards intestinal epithelial cells and Leishmania donovani promastigotes in vitro

31 March 2020

1 reference

Reduction of cisplatin hepatotoxicity by procainamide hydrochloride in rats

31 March 2020

1 reference

Human P450 metabolism of warfarin

31 March 2020

1 reference

Biochemistry and action of clavulanic acid

31 March 2020

1 reference

Investigations into factors determining the duration of action of the beta 2-adrenoceptor agonist, salmeterol

31 March 2020

1 reference

Long-acting beta2-adrenergic formoterol and salmeterol induce the apoptosis of B-chronic lymphocytic leukaemia cells.

31 March 2020

1 reference

The pharmacological basis for the treatment of perennial allergic rhinitis and non-allergic rhinitis with topical corticosteroids

31 March 2020

1 reference

Enhancement of human eosinophil apoptosis by fluticasone propionate, budesonide, and beclomethasone

31 March 2020

1 reference

Immunochemical analysis of sulfonamide drug allergy: identification of sulfamethoxazole-substituted human serum proteins

31 March 2020

1 reference

Rifampicin binding as a probe for subunit interactions in Escherchia coli RNA polymerase

31 March 2020

1 reference

Inhibition of Polypeptide Chain Initiation in Escherichia coli by Elongation Factor G

31 March 2020

1 reference

Inhibition of RNA polymerase activity by the Escherichia coli protein biosynthesis elongation factor Ts

31 March 2020

1 reference

Analysis of the different molecular forms of penicillin-binding protein 1B in Escherichia coli ponB mutants lysogenized with specialized transducing lamba(ponB+) bacteriophages

31 March 2020

1 reference

Canine external carotid vasoconstriction to methysergide, ergotamine and dihydroergotamine: role of 5-HT1B/1D receptors and alpha2-adrenoceptors

31 March 2020

1 reference

Effects of ergotamine on cardiovascular catecholamine receptors in the pithed rat

31 March 2020

1 reference

Effects of caffeine and theophylline on adenosine and benzodiazepine receptors in human brain.

31 March 2020

1 reference

Caffeine-induced locomotor activity: possible involvement of GABAergic-dopaminergic-adenosinergic interaction.

31 March 2020

1 reference

Quantitative Analysis of the Effects of Caffeine on Sperm Motility and Cyclic Adenosine 3’,5’-Monophosphate (AMP) Phosphodiesterase

31 March 2020

1 reference

Niacin and cholesterol: role in cardiovascular disease (review).

31 March 2020

1 reference

Fluorouracil: biochemistry and pharmacology

31 March 2020

1 reference

5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction

31 March 2020

1 reference

Paracetamol: new vistas of an old drug

31 March 2020

1 reference

Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man.

31 March 2020

1 reference

Singly-linked catenation and knotting of cisplatin-DNA adduct by DNA topoisomerase I

31 March 2020

1 reference

12 December 2020

The mechanisms of Ara-C-induced apoptosis of resting B-chronic lymphocytic leukemia cells

1 reference

12 December 2020

Cisplatin plus etoposide in small cell lung cancer

1 reference

12 December 2020

Enhanced antitumor activity of 5-fluorouracil in combination with 2'-deoxyinosine in human colorectal cell lines and human colon tumor xenografts

1 reference

12 December 2020

Endothelin receptors and calcium signaling.

1 reference

12 December 2020

The problem of synergism and antagonism of combined drugs

1 reference

12 December 2020

DNA structural similarity in the 2:1 complexes of the antitumor drugs trabectedin (Yondelis) and chromomycin A3 with an oligonucleotide sequence containing two adjacent TGG binding sites on opposing strands

1 reference

12 December 2020

The growth inhibition of liver cancer cells by paclitaxel and the involvement of extracellular signal-regulated kinase and apoptosis.

1 reference

12 December 2020

Celecoxib acts in a cyclooxygenase-2-independent manner and in synergy with emodin to suppress rat cholangiocarcinoma growth in vitro through a mechanism involving enhanced Akt inactivation and increased activation of caspases-9 and -3.

1 reference

12 December 2020

Enhanced sensitization to taxol-induced apoptosis by herceptin pretreatment in ErbB2-overexpressing breast cancer cells

1 reference

12 December 2020

Paclitaxel and docetaxel enhance the metabolism of doxorubicin to toxic species in human myocardium

1 reference

12 December 2020

In vitro stimulation of warfarin metabolism by quinidine: increases in the formation of 4'- and 10-hydroxywarfarin

1 reference

12 December 2020

Studies on the interaction between fibrates and statins using human hepatic microsomes

1 reference

12 December 2020

Drug combinations for mania

1 reference

12 December 2020

ACE inhibition increases expression of the ETB receptor in kidneys of mice with unilateral obstruction

1 reference

12 December 2020

Demonstration of distinct agonist and antagonist conformations of the A1 adenosine receptor

1 reference

12 December 2020

A cyclophosphamide/DNA phosphoester adduct formed in vitro and in vivo

1 reference

12 December 2020

The search for synergy: a critical review from a response surface perspective.

1 reference

12 December 2020

Emerging applications of network and pathway analysis in drug discovery and development

1 reference

12 December 2020

Advair: combination treatment with fluticasone propionate/salmeterol in the treatment of asthma

1 reference

12 December 2020

DNA arrays as predictors of efficacy of adjuvant/neoadjuvant chemotherapy in breast cancer patients: current data and issues on study design.

1 reference

12 December 2020

New targets and delivery systems for antifungal therapy

1 reference

12 December 2020

Antifungal agents: mode of action in yeast cells

1 reference

12 December 2020

Trimetrexate: experience with solid tumors.

1 reference

12 December 2020

Reassessment of the rationale for the combinations of sulphonamides with diaminopyrimidines

1 reference

12 December 2020

Alkylation of guanosine and deoxyguanosine by phosphoramide mustard

1 reference

12 December 2020

Spontaneous spike activity of spinoreticular tract neurons during sleep and wakefulness.

1 reference

12 December 2020

Effect of beta-lactam antibiotics on bacterial cell growth rate

1 reference

12 December 2020

Azithromycin--spectrum of activity, pharmacokinetics, and clinical applications

1 reference

12 December 2020

Synergistic interaction between oxaliplatin and SN-38 in human gastric cancer cell lines in vitro

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD2683

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19180105%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference