(Q36402208)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16491071%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

review article

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title

Acute lymphoblastic leukaemia: a model for the pharmacogenomics of cancer therapy (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16491071%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

1 reference

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16491071%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

author name string

William E Evans

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16491071%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

language of work or name

English

0 references

publication date

1 February 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16491071%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

published in

Nature Reviews Cancer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16491071%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

volume

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16491071%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

page(s)

117-129

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16491071%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16491071%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrc1800

17 January 2020

exact match

0 references

cites work

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Treatment of acute lymphoblastic leukemia

21 January 2018

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Childhood acute lymphoblastic leukaemia--current status and future perspectives

21 January 2018

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Pharmacogenomics: translating functional genomics into rational therapeutics

21 January 2018

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Pharmacogenetics and cancer therapy

21 January 2018

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Moving towards individualized medicine with pharmacogenomics

21 January 2018

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Inheritance and drug response

21 January 2018

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Cancer pharmacogenetics: polymorphisms, pathways and beyond

21 January 2018

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Pharmacokinetic variability of anticancer agents

21 January 2018

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Pharmacogenetics of cancer therapy: getting personal

21 January 2018

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Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia

21 January 2018

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Isolation of a human thiopurine S-methyltransferase (TPMT) complementary DNA with a single nucleotide transition A719G (TPMT*3C) and its association with loss of TPMT protein and catalytic activity in humans.

21 January 2018

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Human thiopurine methyltransferase pharmacogenetics: gene sequence polymorphisms

21 January 2018

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Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance

21 January 2018

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A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase

21 January 2018

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Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants

21 January 2018

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Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes

21 January 2018

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Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia

21 January 2018

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Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia

21 January 2018

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Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine

21 January 2018

1 reference

Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus

21 January 2018

1 reference

Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia

21 January 2018

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Possible carcinogenic effect of 6-mercaptopurine on bone marrow stem cells: relation to thiopurine metabolism

21 January 2018

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High incidence of secondary brain tumours after radiotherapy and antimetabolites.

21 January 2018

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Preventing Toxicity With a Gene Test

21 January 2018

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With your genes? Take one of these, three times a day

21 January 2018

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21 January 2018

Glutathione transferases

1 reference

Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia.

21 January 2018

1 reference

Polymorphisms within glutathione S-transferase genes and initial response to glucocorticoids in childhood acute lymphoblastic leukaemia.

21 January 2018

1 reference

Glutathione S-transferase polymorphisms and outcome of chemotherapy in childhood acute myeloid leukemia

21 January 2018

1 reference

Increased risk for therapy-associated hematologic malignancies in patients with carcinoma of the breast and combined homozygous gene deletions of glutathione transferases M1 and T1.

21 January 2018

1 reference

Effects of prednisone and genetic polymorphisms on etoposide disposition in children with acute lymphoblastic leukemia

21 January 2018

1 reference

GSTP1 and MDR1 genotypes and central nervous system relapse in childhood acute lymphoblastic leukemia

21 January 2018

1 reference

The GSTT1 deletion polymorphism is associated with initial response to glucocorticoids in childhood acute lymphoblastic leukemia

21 January 2018

1 reference

Glutathione S-transferase genotypes, genetic susceptibility, and outcome of therapy in childhood acute lymphoblastic leukemia

21 January 2018

1 reference

Pharmacogenetics of outcome in children with acute lymphoblastic leukemia

21 January 2018

1 reference

Gene expression and thioguanine nucleotide disposition in acute lymphoblastic leukemia after in vivo mercaptopurine treatment

21 January 2018

1 reference

A gene expression database for the molecular pharmacology of cancer

21 January 2018

1 reference

Acute lymphoblastic leukemia with TEL-AML1 fusion has lower expression of genes involved in purine metabolism and lower de novo purine synthesis

21 January 2018

1 reference

Classification of pediatric acute lymphoblastic leukemia by gene expression profiling

21 January 2018

1 reference

The effect of thiopurine methyltransferase expression on sensitivity to thiopurine drugs

21 January 2018

1 reference

Optimizing antimetabolite-based chemotherapy for the treatment of childhood acute lymphoblastic leukaemia

21 January 2018

1 reference

A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.

21 January 2018

1 reference

Impaired membrane transport in methotrexate-resistant CCRF-CEM cells involves early translation termination and increased turnover of a mutant reduced folate carrier.

21 January 2018

1 reference

Polymorphism G80A in the reduced folate carrier gene and its relationship to methotrexate plasma levels and outcome of childhood acute lymphoblastic leukemia

21 January 2018

1 reference

Reduced folate carrier and dihydrofolate reductase expression in acute lymphocytic leukemia may predict outcome: a Children's Cancer Group Study

21 January 2018

1 reference

Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics

21 January 2018

1 reference

A substrate specific functional polymorphism of human gamma-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells

21 January 2018

1 reference

A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

21 January 2018

1 reference

Thermolabile variant of 5,10-methylenetetrahydrofolate reductase associated with low red-cell folates: implications for folate intake recommendations.

21 January 2018

1 reference

Pharmacogenetics of methotrexate: toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism

21 January 2018

1 reference

Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults

21 January 2018

1 reference

Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia

21 January 2018

1 reference

Role of polymorphisms in MTHFR and MTHFD1 genes in the outcome of childhood acute lymphoblastic leukemia

21 January 2018

1 reference

Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia

21 January 2018

1 reference

Differences in folylpolyglutamate synthetase and dihydrofolate reductase expression in human B-lineage versus T-lineage leukemic lymphoblasts: mechanisms for lineage differences in methotrexate polyglutamylation and cytotoxicity.

21 January 2018

1 reference

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

21 January 2018

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Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

21 January 2018

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DNA microarrays in clinical oncology

21 January 2018

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Gene expression profiling of pediatric acute myelogenous leukemia.

21 January 2018

1 reference

Prediction of immunophenotype, treatment response, and relapse in childhood acute lymphoblastic leukemia using DNA microarrays

21 January 2018

1 reference

Expression profiling of CD34+ hematopoietic stem/ progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia.

21 January 2018

1 reference

FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression

21 January 2018

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Chemosensitivity prediction by transcriptional profiling

21 January 2018

1 reference

Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment

21 January 2018

1 reference

Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia

21 January 2018

1 reference

Global gene expression as a function of germline genetic variation

21 January 2018

1 reference

Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells

21 January 2018

1 reference

Relation between resistance of Philadelphia-chromosome-positive acute lymphoblastic leukaemia to the tyrosine kinase inhibitor STI571 and gene-expression profiles: a gene-expression study

21 January 2018

1 reference

Large-scale genotyping of complex DNA.

21 January 2018

1 reference

Loss of heterozygosity in childhood acute lymphoblastic leukemia detected by genome-wide microarray single nucleotide polymorphism analysis.

21 January 2018

1 reference

Long-term study of the clinical significance of loss of heterozygosity in childhood acute lymphoblastic leukemia.

21 January 2018

1 reference

The INK4a/ARF network in tumour suppression

21 January 2018

1 reference

Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan

21 January 2018

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Gene expression profiling predicts clinical outcome of breast cancer

21 January 2018

1 reference

Molecular determinants of resistance to antiandrogen therapy

21 January 2018

1 reference

Prediction of central nervous system embryonal tumour outcome based on gene expression

21 January 2018

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Pharmacogenomics--drug disposition, drug targets, and side effects

21 January 2018

1 reference

Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms

21 January 2018

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Acute lymphoblastic leukemia

21 January 2018

1 reference

Acute lymphoblastic leukemia

31 March 2020

1 reference

Thiol S-methylation in uremia: erythrocyte enzyme activities and plasma inhibitors

31 March 2020

1 reference

Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia

31 March 2020

1 reference

Polymorphism of the thiopurine S-methyltransferase gene in African-Americans

31 March 2020

1 reference

Etoposide and antimetabolite pharmacology in patients who develop secondary acute myeloid leukemia

31 March 2020

1 reference

Thiopurine S-methyltransferase: a genetic polymorphism that affects a small number of drugs in a big way

31 March 2020

1 reference

Glutathione S-transferase genotypes in children who develop treatment-related acute myeloid malignancies

31 March 2020

1 reference

Hypoxanthine-guanine phosphoribosyl-transferase in childhood leukemia: relation with immunophenotype, in vitro drug resistance and clinical prognosis

31 March 2020

1 reference

A polymorphism (80G->A) in the reduced folate carrier gene and its associations with folate status and homocysteinemia

31 March 2020

1 reference

Polymorphism of the thymidylate synthase gene and outcome of acute lymphoblastic leukaemia

31 March 2020

1 reference

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

31 March 2020

1 reference

Lymphoid gene expression as a predictor of risk of secondary brain tumors

31 March 2020

1 reference

Gene expression as a drug discovery tool

31 March 2020

1 reference

Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation

31 March 2020

1 reference

Mining the genome for combination therapies

31 March 2020

1 reference

An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC1800

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16491071%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference