(Q38028522)

27 August 2017

title

Non-mammalian animal models of Parkinson's disease for drug discovery (English)

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27 August 2017

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Kah-Leong Lim

1

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27 August 2017

language of work or name

English

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publication date

5 January 2010

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Expert Opinion on Drug Discovery

27 August 2017

published in

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27 August 2017

volume

5

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27 August 2017

issue

2

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27 August 2017

page(s)

165-176

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Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030.

27 August 2017

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21 January 2018

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21 January 2018

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Caenorhabditis elegans in Parkinson's disease drug discovery: addressing an unmet medical need

21 January 2018

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Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

21 January 2018

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A genetic screen in Caenorhabditis elegans for dopamine neuron insensitivity to 6-hydroxydopamine identifies dopamine transporter mutants impacting transporter biosynthesis and trafficking

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21 January 2018

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Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease

21 January 2018

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3-Hydroxymorphinan, a metabolite of dextromethorphan, protects nigrostriatal pathway against MPTP-elicited damage both in vivo and in vitro.

21 January 2018

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Neuroprotection and dopamine agonists

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease

21 January 2018

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21 January 2018

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21 January 2018

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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

21 January 2018

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

21 January 2018

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Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin

21 January 2018

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Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease

21 January 2018

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Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress

21 January 2018

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21 January 2018

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21 January 2018

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Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficits

21 January 2018

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Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis.

21 January 2018

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21 January 2018

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21 January 2018

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The PINK1/Parkin pathway regulates mitochondrial morphology

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460440903527675

The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460440903527675

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

21 January 2018

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Pharmacological prevention of Parkinson disease in Drosophila.

21 January 2018

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Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460440903527675

Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460440903527675

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440903527675

Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440903527675

Microfluidic system for on-chip high-throughput whole-animal sorting and screening at subcellular resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440903527675

Sub-cellular precision on-chip small-animal immobilization, multi-photon imaging and femtosecond-laser manipulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440903527675

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440903527675

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440903527675

10.1517/17460440903527675

21 January 2018

Identifiers

DOI

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27 August 2017

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