(Q47069000)

4 January 2018

title

A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress (English)

1 reference

4 January 2018

Probable 26S proteasome regulatory subunit 4 CELE_F29G9.5

main subject

Caenorhabditis elegans

0 references

1 reference

UBiquitin Conjugating enzyme CELE_R01H2.6

1 reference

Ubiquitin-conjugating enzyme E2 2 CELE_M7.1

1 reference

U-box domain-containing protein CELE_T09B4.10

1 reference

1 reference

2

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4 January 2018

Wolfdieter Springer

object named as

Wolfdieter Springer

series ordinal

1

0 references

author name string

Enrico Schmidt

series ordinal

3

1 reference

4 January 2018

Ralf Baumeister

series ordinal

4

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4 January 2018

publication date

4 October 2005

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4 January 2018

published in

Human Molecular Genetics

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4 January 2018

volume

14

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4 January 2018

issue

22

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4 January 2018

page(s)

3407-3423

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4 January 2018

Therapeutic strategies for Parkinson's disease based on data derived from genetic research

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Alpha-synuclein and presynaptic function: implications for Parkinson's disease.

21 January 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 January 2018

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Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

21 January 2018

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alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

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The role of alpha-synuclein in Parkinson's disease: insights from animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Mechanisms underlying ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

A trip to the ER: coping with stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin-proteasome connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

A regulatory link between ER-associated protein degradation and the unfolded-protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

How does parkin ligate ubiquitin to Parkinson's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Parkin genetics: one model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Effect of wild-type or mutant Parkin on oxidative damage, nitric oxide, antioxidant defenses, and the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

The C289G and C418R missense mutations cause rapid sequestration of human Parkin into insoluble aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Pathogenic mutations inactivate parkin by distinct mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Multiubiquitylation by E4 enzymes: 'one size' doesn't fit all.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

RING finger 1 mutations in Parkin produce altered localization of the protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Alterations in the solubility and intracellular localization of parkin by several familial Parkinson's disease-linked point mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

A survival pathway for Caenorhabditis elegans with a blocked unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

The neurological mutant quaking(viable) is Parkin deficient

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Siah-1 facilitates ubiquitination and degradation of synphilin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Dorfin Localizes to Lewy Bodies and Ubiquitylates Synphilin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

'Unfolding' pathways in neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Caenorhabditis elegans MPP+ model of Parkinson's disease for high-throughput drug screenings

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Caught in the act: alpha-synuclein is the culprit in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

Loss of locus coeruleus neurons and reduced startle in parkin null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

The Cellular Protein Level of Parkin Is Regulated by Its Ubiquitin-like Domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI371

21 January 2018

Identifiers

DOI

10.1093/HMG/DDI371

1 reference

4 January 2018

1 reference

4 January 2018