(Q38029137)

27 August 2017

title

Discovery and design of carbohydrate-based therapeutics (English)

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27 August 2017

Laura Cipolla

1

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27 August 2017

Ana C Araújo

2

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27 August 2017

Davide Bini

3

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27 August 2017

Luca Gabrielli

4

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27 August 2017

Laura Russo

5

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27 August 2017

Nasrin Shaikh

6

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27 August 2017

language of work or name

English

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publication date

17 June 2010

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Expert Opinion on Drug Discovery

27 August 2017

published in

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27 August 2017

volume

5

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27 August 2017

issue

8

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27 August 2017

page(s)

721-737

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Nothing in glycobiology makes sense, except in the light of evolution

27 August 2017

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An appreciation of Elvin A. Kabat (1914-2000): scientist, educator and a founder of modern carbohydrate biology.

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Glycomics: a pathway to a class of new and improved therapeutics

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Automated carbohydrate synthesis as platform to address fundamental aspects of glycobiology--current status and future challenges

21 January 2018

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Opportunities and challenges in synthetic oligosaccharide and glycoconjugate research

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Carbohydrates as the next frontier in pharmaceutical research

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New principles for glycoside-bond formation

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Engineering of glycosidases and glycosyltransferases

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Glycosyltransferases: structures, functions, and mechanisms

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Toward fully synthetic N-linked glycoproteins

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Toward homogeneous erythropoietin: fine tuning of the C-terminal acyl donor in the chemical synthesis of the Cys29-Gly77 glycopeptide domain

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Construction and structural characterization of versatile lactosaminoglycan-related compound library for the synthesis of complex glycopeptides and glycosphingolipids.

21 January 2018

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Multi-component one-pot synthesis of the tumor-associated carbohydrate antigen Globo-H based on preactivation of thioglycosyl donors

21 January 2018

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Total syntheses of tumor-related antigens N3: probing the feasibility limits of the glycal assembly method

21 January 2018

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Carbohydrate diversity: synthesis of glycoconjugates and complex carbohydrates

21 January 2018

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A stereoselective approach for the synthesis of alpha-sialosides

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2009 Claude S. Hudson Award in Carbohydrate Chemistry. Carbohydrates: a frontier in medicinal chemistry.

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A synthetic antithrombin III binding pentasaccharide is now a drug! What comes next?

21 January 2018

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Carbohydrate vaccines: developing sweet solutions to sticky situations?

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21 January 2018

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21 January 2018

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Carbohydrate based vaccines

21 January 2018

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Recent developments in synthetic oligosaccharide-based bacterial vaccines

21 January 2018

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Antigenic glycans in parasitic infections: implications for vaccines and diagnostics

21 January 2018

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CUTANEOUS REACTIONS IN PNEUMONIA. THE DEVELOPMENT OF ANTIBODIES FOLLOWING THE INTRADERMAL INJECTION OF TYPE-SPECIFIC POLYSACCHARIDE.

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21 January 2018

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21 January 2018

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Olefin metathesis for site-selective protein modification

21 January 2018

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Antigenicity and immunogenicity of a synthetic oligosaccharide-protein conjugate vaccine against Haemophilus influenzae type b.

21 January 2018

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Synthesis and medical applications of oligosaccharides

21 January 2018

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Progress towards development of a cholera subunit vaccine.

21 January 2018

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Vaccines in the era of genomics: the pneumococcal challenge

21 January 2018

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Chemical glycosylation in the synthesis of glycoconjugate antitumour vaccines

21 January 2018

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Carbohydrate vaccines as immunotherapy for cancer

21 January 2018

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Glycoconjugates in cancer therapy.

21 January 2018

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From the Laboratory to the Clinic: A Retrospective on Fully Synthetic Carbohydrate-Based Anticancer Vaccines Frequently used abbreviations are listed in the appendix

21 January 2018

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Vaccination with Theratope (STn-KLH) as treatment for breast cancer

21 January 2018

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A fully synthetic therapeutic vaccine candidate targeting carcinoma-associated Tn carbohydrate antigen induces tumor-specific antibodies in nonhuman primates

21 January 2018

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Immunotherapy for cancer: synthetic carbohydrate-based vaccines

21 January 2018

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Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Pursuit of optimal carbohydrate-based anticancer vaccines: preparation of a multiantigenic unimolecular glycopeptide containing the Tn, MBr1, and Lewis(y) antigens

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Carbohydrate microarray for profiling the antibodies interacting with Globo H tumor antigen

21 January 2018

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Robust immune responses elicited by a fully synthetic three-component vaccine

21 January 2018

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Siglecs as targets for therapy in immune-cell-mediated disease

21 January 2018

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Siglecs and their roles in the immune system

21 January 2018

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Clusters, bundles, arrays and lattices: novel mechanisms for lectin-saccharide-mediated cellular interactions

21 January 2018

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Potentiation of fibroblast growth factor activity by synthetic heparin oligosaccharide glycodendrimers

21 January 2018

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From carbohydrate leads to glycomimetic drugs

21 January 2018

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Emerging themes in medicinal glycoscience

21 January 2018

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Recent developments of transition-state analogue glycosidase inhibitors of non-natural product origin

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Synthesis and conformational and biological aspects of carbasugars.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Rational design of potent sialidase-based inhibitors of influenza virus replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Discovery and development of GS 4104 (oseltamivir): an orally active influenza neuraminidase inhibitor

21 January 2018

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Guidance on the use of miglustat for treating patients with type 1 Gaucher disease

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Miglustat for treatment of Niemann-Pick C disease: a randomised controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.497811

A cystic fibrosis respiratory epithelial cell chronically treated by miglustat acquires a non-cystic fibrosis-like phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Suppressive effects of swainsonine on C6 glioma cell in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Active-site-specific chaperone therapy for Fabry disease. Yin and Yang of enzyme inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Synthetic glycoprotein mimics inhibit L-selectin-mediated rolling and promote L-selectin shedding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Selectinminus signCarbohydrate Interactions: From Natural Ligands to Designed Mimics

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Selectin and selectin ligand binding: a bittersweet attraction

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Blocking of responses to endotoxin by E5564 in healthy volunteers with experimental endotoxemia

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Glycolipids and benzylammonium lipids as novel antisepsis agents: synthesis and biological characterization

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Profiling the sulfation specificities of glycosaminoglycan interactions with growth factors and chemotactic proteins using microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Structural insights into biological roles of protein-glycosaminoglycan interactions

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Synthesis of selected LeY and KH-1 analogues: a medicinal chemistry approach to vaccine optimization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Vaccination of patients with small-cell lung cancer with synthetic fucosyl GM-1 conjugated to keyhole limpet hemocyanin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Preparation and immunological studies of protein conjugates of N -acylneuraminic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Synthesis of thioether-linked analogues of the 2,3-sialyl-TF and MECA-79 antigens: mucin-type glycopeptides associated with cancer and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Synthesis and immunological properties of N-modified GM3 antigens as therapeutic cancer vaccines

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.497811

The beta-D-glucose scaffold as a beta-turn mimetic

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Carbohydrates as scaffolds in drug discovery

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Molecular diversity through sugar scaffolds

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Bicyclic carbohydrate-derived scaffolds for combinatorial libraries

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Synthesis and conformational analysis of fructose-derived scaffolds: molecular diversity from a single molecule

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Selective cytotoxicity of a bicyclic Ras inhibitor in cancer cells expressing K-Ras(G13D).

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Strategies in developing promising histone deacetylase inhibitors

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Fructose-fused gamma-butyrolactones and lactams, synthesis and biological evaluation as GABA receptor ligands

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2010.497811

Chemoselective Neoglycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2010.497811

10.1517/17460441.2010.497811

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference