(Q38030832)

27 August 2017

Adaptive immunity in obesity and insulin resistance (English)

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27 August 2017

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Henrike Sell

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author name string

Christiane Habich

series ordinal

2

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27 August 2017

Juergen Eckel

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3

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27 August 2017

language of work or name

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31 July 2012

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Nature Reviews Endocrinology

27 August 2017

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27 August 2017

8

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27 August 2017

12

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27 August 2017

709-716

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https://scigraph.springernature.com/pub.10.1038/nrendo.2012.114

27 August 2017

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cites work

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Abdominal obesity and metabolic syndrome

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Macrophages, inflammation, and insulin resistance

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Inflammation and metabolic disorders

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Obesity is associated with macrophage accumulation in adipose tissue

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

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Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

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Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice

31 March 2020

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Targeted deletion of adipocytes by apoptosis leads to adipose tissue recruitment of alternatively activated M2 macrophages

31 March 2020

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Adipokines: inflammation and the pleiotropic role of white adipose tissue

31 March 2020

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Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes

31 March 2020

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Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation

31 March 2020

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Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response

31 March 2020

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Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation

31 March 2020

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Adipose tissue remodeling and obesity

31 March 2020

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Obesity induces a phenotypic switch in adipose tissue macrophage polarization

31 March 2020

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Regulatory macrophages: setting the threshold for therapy

31 March 2020

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Human primary adipocytes exhibit immune cell function: adipocytes prime inflammation independent of macrophages

31 March 2020

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T-cell recruitment and Th1 polarization in adipose tissue during diet-induced obesity in C57BL/6 mice

31 March 2020

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Adipose tissue lymphocytes: types and roles

31 March 2020

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Adaptive immunity and adipose tissue biology

31 March 2020

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Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

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Adipose tissues as an ancestral immune organ: site-specific change in obesity.

31 March 2020

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Normalization of obesity-associated insulin resistance through immunotherapy

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IL-17 regulates adipogenesis, glucose homeostasis, and obesity

31 March 2020

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Interplay between human adipocytes and T lymphocytes in obesity: CCL20 as an adipochemokine and T lymphocytes as lipogenic modulators.

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T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity

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Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-gamma in inflammation in human adipose tissue

31 March 2020

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Inflammatory concepts of obesity

31 March 2020

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T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance

31 March 2020

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Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance

31 March 2020

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CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages.

31 March 2020

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PPARgamma activation attenuates T-lymphocyte-dependent inflammation of adipose tissue and development of insulin resistance in obese mice

31 March 2020

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Peroxisome proliferator-activated receptor gamma activation promotes infiltration of alternatively activated macrophages into adipose tissue.

31 March 2020

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B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

31 March 2020

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Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.

31 March 2020

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A key role of leptin in the control of regulatory T cell proliferation

31 March 2020

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Visceral adipose inflammation in obesity is associated with critical alterations in tregulatory cell numbers

31 March 2020

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CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

31 March 2020

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Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese mice

31 March 2020

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Invariant natural killer T cells: bridging innate and adaptive immunity

31 March 2020

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NKT cells: T lymphocytes with innate effector functions

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity.

31 March 2020

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Toll-like receptors regulate B cell cytokine production in patients with diabetes

31 March 2020

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Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity

31 March 2020

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Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages

31 March 2020

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TLR4 links innate immunity and fatty acid-induced insulin resistance

31 March 2020

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An obesity-associated gut microbiome with increased capacity for energy harvest

31 March 2020

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Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5

31 March 2020

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High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse

31 March 2020

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Gut microbiome, obesity, and metabolic dysfunction

31 March 2020

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Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Chylomicrons promote intestinal absorption and systemic dissemination of dietary antigen (ovalbumin) in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Chylomicrons promote intestinal absorption of lipopolysaccharides

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Preferential uptake of dietary Fatty acids in adipose tissue and muscle in the postprandial period.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

T-lymphocyte responses to intestinally absorbed antigens can contribute to adipose tissue inflammation and glucose intolerance during high fat feeding

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Oral tolerance and its relation to food hypersensitivities

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Mechanisms of early improvement/resolution of type 2 diabetes after bariatric surgery

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Bariatric surgery, adipose tissue and gut microbiota

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Targeting gut microbiota in obesity: effects of prebiotics and probiotics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

The gut microbiome as therapeutic target

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

T cell-mediated inflammation in adipose tissue does not cause insulin resistance in hyperlipidemic mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Abdominal fat mass is associated with adaptive immune activation: the CODAM Study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Potential antiinflammatory role of insulin via the preferential polarization of effector T cells toward a T helper 2 phenotype.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

The effects of weight loss and gastric banding on the innate and adaptive immune system in type 2 diabetes and prediabetes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Increased levels of both Th1 and Th2 cytokines in subjects with metabolic syndrome (CURES-103).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Stromal cell-derived factor-1 (SDF-1)/chemokine (C-X-C motif) receptor 4 (CXCR4) axis activation induces intra-islet glucagon-like peptide-1 (GLP-1) production and enhances beta cell survival

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Inflammation, stress, and diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

IKK-beta links inflammation to obesity-induced insulin resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

A central role for JNK in obesity and insulin resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Mitochondrial dysfunction and insulin resistance from the outside in: extracellular matrix, the cytoskeleton, and mitochondria

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

B cell therapy is β-tested: Rituximab puts a pause on β-cell destruction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Peroxisome proliferator-activated receptor delta agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Deficiency of haematopoietic-cell-derived IL-10 does not exacerbate high-fat-diet-induced inflammation or insulin resistance in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Lipoic acid attenuates innate immune infiltration and activation in the visceral adipose tissue of obese insulin resistant mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Insulin-sensitive obesity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2012.114

Jejunal mucosal injury and restitution: role of hydrolytic products of food digestion.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22847239

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Clearance of lipoprotein remnant particles in adipose tissue and muscle in humans

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22847239

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRENDO.2012.114

1 reference

Dimensions Publication ID

27 August 2017

0 references

1 reference