(Q38031743)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22858652%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22858652%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22858652%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

author name string

Tamas L Horvath

series ordinal

2

1 reference

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9 February 2020

publication date

3 August 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22858652%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Drug Discovery

9 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22858652%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

volume

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22858652%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22858652%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

page(s)

675-691

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22858652%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrd3739

9 February 2020

exact match

0 references

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A role for melanin-concentrating hormone in the central regulation of feeding behaviour

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Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons

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Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations.

21 January 2018

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Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

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21 January 2018

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Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

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Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice

21 January 2018

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Ablation of neurons expressing agouti-related protein activates fos and gliosis in postsynaptic target regions

21 January 2018

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Positional cloning of the mouse obese gene and its human homologue

21 January 2018

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Weight-reducing effects of the plasma protein encoded by the obese gene

21 January 2018

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21 January 2018

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Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor

21 January 2018

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Identification and expression cloning of a leptin receptor, OB-R

21 January 2018

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Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice

21 January 2018

1 reference

Congenital leptin deficiency is associated with severe early-onset obesity in humans

21 January 2018

1 reference

Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

21 January 2018

1 reference

Serum immunoreactive-leptin concentrations in normal-weight and obese humans

21 January 2018

1 reference

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

21 January 2018

1 reference

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice

21 January 2018

1 reference

Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice

21 January 2018

1 reference

Anatomy and regulation of the central melanocortin system

21 January 2018

1 reference

Endoplasmic reticulum stress plays a central role in development of leptin resistance

21 January 2018

1 reference

Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

21 January 2018

1 reference

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

21 January 2018

1 reference

Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity

21 January 2018

1 reference

Pex3p-dependent peroxisomal biogenesis initiates in the endoplasmic reticulum of human fibroblasts

21 January 2018

1 reference

Peroxisome biogenesis: the peroxisomal endomembrane system and the role of the ER

21 January 2018

1 reference

The evolutionary origin of peroxisomes: an ER-peroxisome connection.

21 January 2018

1 reference

UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals

21 January 2018

1 reference

Fuel utilization by hypothalamic neurons: roles for ROS.

21 January 2018

1 reference

Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity.

21 January 2018

1 reference

Obesity is associated with hypothalamic injury in rodents and humans

21 January 2018

1 reference

A review of the clinical pharmacology of methamphetamine

21 January 2018

1 reference

Mixing pleasures: review of the effects of drugs on sex behavior in humans and animal models

21 January 2018

1 reference

Pharmacological targeting of the serotonergic system for the treatment of obesity

21 January 2018

1 reference

Hyperphagia and Increased Growth in Rats After Intraventricular Injection of 5,7-Dihydroxytryptamine

21 January 2018

1 reference

Activation of central melanocortin pathways by fenfluramine

21 January 2018

1 reference

Effects of chronic fenfluramine administration on hypothalamic neuropeptide mRNA expression.

21 January 2018

1 reference

Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors

21 January 2018

1 reference

Effect on dietary fat absorption of orlistat, administered at different times relative to meal intake

21 January 2018

1 reference

Cetilistat (ATL-962), a novel pancreatic lipase inhibitor, ameliorates body weight gain and improves lipid profiles in rats

21 January 2018

1 reference

Cetilistat (ATL-962), a novel lipase inhibitor: a 12-week randomized, placebo-controlled study of weight reduction in obese patients

21 January 2018

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Reduction of dietary fat absorption by the novel gastrointestinal lipase inhibitor cetilistat in healthy volunteers

21 January 2018

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Weight loss, HbA1c reduction, and tolerability of cetilistat in a randomized, placebo-controlled phase 2 trial in obese diabetics: comparison with orlistat (Xenical).

21 January 2018

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Role of orlistat in the treatment of obese patients with type 2 diabetes. A 1-year randomized double-blind study

21 January 2018

1 reference

Effects of weight loss with orlistat on glucose tolerance and progression to type 2 diabetes in obese adults

21 January 2018

1 reference

Clinical efficacy of orlistat therapy in overweight and obese patients with insulin-treated type 2 diabetes: A 1-year randomized controlled trial

21 January 2018

1 reference

Effect of orlistat in overweight and obese patients with type 2 diabetes treated with metformin

21 January 2018

1 reference

The effects of orlistat on body weight and glycaemic control in overweight patients with type 2 diabetes: a randomized, placebo-controlled trial

21 January 2018

1 reference

International trial of long-term dexfenfluramine in obesity.

21 January 2018

1 reference

Dexfenfluramine in the treatment of severe obesity: a placebo-controlled investigation of the effects on weight loss, cardiovascular risk factors, food intake and eating behaviour

21 January 2018

1 reference

A population-based study of appetite-suppressant drugs and the risk of cardiac-valve regurgitation

21 January 2018

1 reference

Appetite suppressants and valvular heart disease - a systematic review

21 January 2018

1 reference

Appetite-suppressant drugs and the risk of primary pulmonary hypertension. International Primary Pulmonary Hypertension Study Group

21 January 2018

1 reference

Appetite Suppressants and Valvular Heart Disease

21 January 2018

1 reference

High incidence of primary pulmonary hypertension associated with appetite suppressants in Belgium

21 January 2018

1 reference

Sibutramine in weight control: a dose-ranging, efficacy study

21 January 2018

1 reference

Effects of sibutramine on resting metabolic rate and weight loss in overweight women

21 January 2018

1 reference

Sibutramine produces dose-related weight loss

21 January 2018

1 reference

Sibutramine enhances insulin sensitivity ameliorating metabolic parameters in a double-blind, randomized, placebo-controlled trial

21 January 2018

1 reference

Use of sibutramine in overweight adult hispanic patients with type 2 diabetes mellitus: a 12-month, randomized, double-blind, placebo-controlled clinical trial

21 January 2018

1 reference

Use of sibutramine in obese mexican adolescents: a 6-month, randomized, double-blind, placebo-controlled, parallel-group trial.

21 January 2018

1 reference

Effect of sibutramine on weight reduction in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial

21 January 2018

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The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis

21 January 2018

1 reference

The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake

21 January 2018

1 reference

SR141716A, a potent and selective antagonist of the brain cannabinoid receptor

21 January 2018

1 reference

Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia

21 January 2018

1 reference

Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study

21 January 2018

1 reference

Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial

21 January 2018

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Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials

21 January 2018

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Neuropsychiatric adverse effects of centrally acting antiobesity drugs.

21 January 2018

1 reference

Multiple-dose pharmacokinetics, pharmacodynamics, and safety of taranabant, a novel selective cannabinoid-1 receptor inverse agonist, in healthy male volunteers

21 January 2018

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A randomized trial of lifestyle modification and taranabant for maintaining weight loss achieved with a low-calorie diet

21 January 2018

1 reference

A clinical trial assessing the safety and efficacy of the CB1R inverse agonist taranabant in obese and overweight patients: low-dose study

21 January 2018

1 reference

A one-year study to assess the safety and efficacy of the CB1R inverse agonist taranabant in overweight and obese patients with type 2 diabetes

21 January 2018

1 reference

A clinical trial assessing the safety and efficacy of taranabant, a CB1R inverse agonist, in obese and overweight patients: a high-dose study

21 January 2018

1 reference

Discovery of 1-[9-(4-chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic acid amide hydrochloride (CP-945,598), a novel, potent, and selective cannabinoid type 1 receptor antagonist

21 January 2018

1 reference

In vitro and in vivo pharmacology of CP-945,598, a potent and selective cannabinoid CB(1) receptor antagonist for the management of obesity

21 January 2018

1 reference

Efficacy and safety of CP-945,598, a selective cannabinoid CB1 receptor antagonist, on weight loss and maintenance

21 January 2018

1 reference

Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats

21 January 2018

1 reference

Peripherally acting CB1-receptor antagonist: the relative importance of central and peripheral CB1 receptors in adiposity control

21 January 2018

1 reference

Energy balance regulation by endocannabinoids at central and peripheral levels

21 January 2018

1 reference

Central serotonin and melanocortin pathways regulating energy homeostasis

21 January 2018

1 reference

Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity

21 January 2018

1 reference

Lorcaserin, a novel selective human 5-hydroxytryptamine2C agonist: in vitro and in vivo pharmacological characterization

21 January 2018

1 reference

Multicenter, placebo-controlled trial of lorcaserin for weight management

21 January 2018

1 reference

A one-year randomized trial of lorcaserin for weight loss in obese and overweight adults: the BLOSSOM trial

21 January 2018

1 reference

Immunohistochemical localisation of the 5-HT2C receptor protein in the rat CNS.

21 January 2018

1 reference

Localization of the 5-hydroxytryptamine2C receptor protein in human and rat brain using specific antisera.

21 January 2018

1 reference

Distribution of the 5-hydroxytryptamine2C receptor protein in adult rat brain and spinal cord determined using a receptor-directed antibody: effect of 5,7-dihydroxytryptamine.

21 January 2018

1 reference

Bupropion for weight loss: an investigation of efficacy and tolerability in overweight and obese women

21 January 2018

1 reference

Bupropion SR enhances weight loss: a 48-week double-blind, placebo- controlled trial.

21 January 2018

1 reference

Rational design of a combination medication for the treatment of obesity

21 January 2018

1 reference

Norepinephrine and the control of food intake

21 January 2018

1 reference

A role for dopamine in feeding responses produced by orexigenic agents

21 January 2018

1 reference

Dysregulation of dopamine signaling in the dorsal striatum inhibits feeding

21 January 2018

1 reference

Cre recombinase-mediated restoration of nigrostriatal dopamine in dopamine-deficient mice reverses hypophagia and bradykinesia

21 January 2018

1 reference

Leptin regulates the reward value of nutrient

21 January 2018

1 reference

Weight loss with naltrexone SR/bupropion SR combination therapy as an adjunct to behavior modification: the COR-BMOD trial.

21 January 2018

1 reference

Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

21 January 2018

1 reference

Slim spoils for obesity drugs

21 January 2018

1 reference

Appetite suppressants, cardiac valve disease and combination pharmacotherapy

21 January 2018

1 reference

A randomized double-blind placebo-controlled study of the long-term efficacy and safety of topiramate in the treatment of obese subjects

21 January 2018

1 reference

A 6-month randomized, placebo-controlled, dose-ranging trial of topiramate for weight loss in obesity

21 January 2018

1 reference

Efficacy and safety of topiramate in the treatment of obese subjects with essential hypertension

21 January 2018

1 reference

Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial

21 January 2018

1 reference

Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP)

21 January 2018

1 reference

Modulation of glucose transport in skeletal muscle by reactive oxygen species

21 January 2018

1 reference

Cardiac hypertrophy, substrate utilization and metabolic remodelling: cause or effect?

21 January 2018

1 reference

Energy metabolic phenotype of the cardiomyocyte during development, differentiation, and postnatal maturation

21 January 2018

1 reference

Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction.

21 January 2018

1 reference

Myocardial substrate metabolism in the normal and failing heart

21 January 2018

1 reference

Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients

21 January 2018

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Fasting and differential chemotherapy protection in patients

21 January 2018

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Fasting and cancer treatment in humans: A case series report.

21 January 2018

1 reference

Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy.

21 January 2018

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Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

21 January 2018

1 reference

Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production

21 January 2018

1 reference

The effects of caloric restriction- and exercise-induced weight loss on left ventricular diastolic function.

21 January 2018

1 reference

Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: a randomized controlled trial.

21 January 2018

1 reference

Reduced bone mineral density is not associated with significantly reduced bone quality in men and women practicing long-term calorie restriction with adequate nutrition.

21 January 2018

1 reference

Calorie restriction attenuates LPS-induced sickness behavior and shifts hypothalamic signaling pathways to an anti-inflammatory bias

21 January 2018

1 reference

Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity

21 January 2018

1 reference

Salsalate improves glycemia and inflammatory parameters in obese young adults

21 January 2018

1 reference

Resveratrol improves health and survival of mice on a high-calorie diet

21 January 2018

1 reference

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

21 January 2018

1 reference

Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

21 January 2018

1 reference

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

21 January 2018

1 reference

FoxO1 and HNF-4 are involved in regulation of hepatic glucokinase gene expression by resveratrol

21 January 2018

1 reference

Resveratrol is an effective inducer of CArG-driven TNF-alpha gene therapy.

21 January 2018

1 reference

Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase

21 January 2018

1 reference

Resveratrol stimulates AMP kinase activity in neurons

21 January 2018

1 reference

Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism

21 January 2018

1 reference

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

21 January 2018

1 reference

Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.

21 January 2018

1 reference

AMPK and PPARdelta agonists are exercise mimetics

21 January 2018

1 reference

Ghrelin controls hippocampal spine synapse density and memory performance

21 January 2018

1 reference

Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite

21 January 2018

1 reference

Leptin promotes dopamine transporter and tyrosine hydroxylase activity in the nucleus accumbens of Sprague-Dawley rats

21 January 2018

1 reference

Modulation of the mesolimbic dopamine system by leptin

21 January 2018

1 reference

Leptin regulation of the mesoaccumbens dopamine pathway.

21 January 2018

1 reference

Leptin receptor signaling in midbrain dopamine neurons regulates feeding

21 January 2018

1 reference

Exercise increases insulin signaling in the hippocampus: physiological effects and pharmacological impact of intracerebroventricular insulin administration in mice.

21 January 2018

1 reference

Modulation of blood pressure by central melanocortinergic pathways

21 January 2018

1 reference

Melanocortin signalling and the regulation of blood pressure in human obesity

21 January 2018

1 reference

Reversal of obesity by targeted ablation of adipose tissue

21 January 2018

1 reference

A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys

21 January 2018

1 reference

Fumagillin reduces adipose tissue formation in murine models of nutritionally induced obesity

21 January 2018

1 reference

Effect of fumagillin on adipocyte differentiation and adipogenesis

21 January 2018

1 reference

Peptide designed to elicit apoptosis in adipose tissue endothelium reduces food intake and body weight

21 January 2018

1 reference

Brown adipose tissue: function and physiological significance

21 January 2018

1 reference

Brown fat biology and thermogenesis

21 January 2018

1 reference

Genome sequencing reveals insights into physiology and longevity of the naked mole rat

21 January 2018

1 reference

Identification and importance of brown adipose tissue in adult humans

21 January 2018

1 reference

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans.

21 January 2018

1 reference

Brown adipose tissue activity controls triglyceride clearance.

21 January 2018

1 reference

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

21 January 2018

1 reference

The metabolically healthy but obese individual presents a favorable inflammation profile

21 January 2018

1 reference

What are the physical characteristics associated with a normal metabolic profile despite a high level of obesity in postmenopausal women?

21 January 2018

1 reference

Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men.

21 January 2018

1 reference

Impact of BMI and the metabolic syndrome on the risk of diabetes in middle-aged men.

21 January 2018

1 reference

Comparative effectiveness of weight-loss interventions in clinical practice

21 January 2018

1 reference

A two-year randomized trial of obesity treatment in primary care practice

21 January 2018

1 reference

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

21 January 2018

1 reference

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

21 January 2018

1 reference

Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygous mutation in the POMC gene

21 January 2018

1 reference

A frameshift mutation in human MC4R is associated with a dominant form of obesity

21 January 2018

1 reference

A frameshift mutation in MC4R associated with dominantly inherited human obesity

21 January 2018

1 reference

Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

21 January 2018

1 reference

Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity

21 January 2018

1 reference

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene

21 January 2018

1 reference

Binge eating as a major phenotype of melanocortin 4 receptor gene mutations

21 January 2018

1 reference

The central melanocortin system can directly regulate serum insulin levels

21 January 2018

1 reference

The HPA axis modulates the CNS melanocortin control of liver triacylglyceride metabolism

21 January 2018

1 reference

Melanocortin signaling in the CNS directly regulates circulating cholesterol

21 January 2018

1 reference

NPY and MC4R signaling regulate thyroid hormone levels during fasting through both central and peripheral pathways

21 January 2018

1 reference

Central neuropeptide Y infusion and melanocortin 4 receptor antagonism inhibit thyrotropic function by divergent pathways.

21 January 2018

1 reference

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

21 January 2018

1 reference

GABAergic signaling by AgRP neurons prevents anorexia via a melanocortin-independent mechanism

21 January 2018

1 reference

Starvation after AgRP neuron ablation is independent of melanocortin signaling

21 January 2018

1 reference

Stimulation of food intake by muscimol and beta endorphin

21 January 2018

1 reference

GABA stimulation and blockade in the hypothalamus and midbrain: Effects on feeding and locomotor activity

21 January 2018

1 reference

GABA and hypothalamic feeding systems. I. Topographic analysis of the effects of microinjections of muscimol

21 January 2018

1 reference

Deciphering a neuronal circuit that mediates appetite

21 January 2018

1 reference

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

21 January 2018

1 reference

Ghrelin induces adiposity in rodents

21 January 2018

1 reference

The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis

21 January 2018

1 reference

Differential role of the hippocampus, amygdala, and dorsal raphe nucleus in regulating feeding, memory, and anxiety-like behavioral responses to ghrelin

21 January 2018

1 reference

Ghrelin modulates brain activity in areas that control appetitive behavior

21 January 2018

1 reference

Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop

21 January 2018

1 reference

Ghrelin raises [Ca2+]i via AMPK in hypothalamic arcuate nucleus NPY neurons

21 January 2018

1 reference

Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice

21 January 2018

1 reference

Feeding behavior in dopamine-deficient mice

21 January 2018

1 reference

Dopamine is required for hyperphagia in Lep(ob/ob) mice

21 January 2018

1 reference

Leptin signaling in brain: A link between nutrition and cognition?

21 January 2018

1 reference

Leptin regulates striatal regions and human eating behavior

21 January 2018

1 reference

FoxO1 target Gpr17 activates AgRP neurons to regulate food intake

21 January 2018

1 reference

Serotonin Reciprocally Regulates Melanocortin Neurons to Modulate Food Intake

21 January 2018

1 reference

PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans

21 January 2018

1 reference

Suspense builds on anti-obesity rollercoaster ride

21 January 2018

1 reference

31 March 2020

1 reference

31 March 2020

1 reference

Localization of a "feeding center" in the hypothalamus of the rat.

31 March 2020

1 reference

Post-embryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotype

31 March 2020

1 reference

Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis

31 March 2020

1 reference

Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats

31 March 2020

1 reference

Diabetes, a New Mutation in the Mouse

31 March 2020

1 reference

The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats. Reduced sensitivity compared with lean animals

31 March 2020

1 reference

A comparison of the effects of tryptamine and 5-hydroxytryptamine on feeding following injection into the paraventricular nucleus of the hypothalamus

31 March 2020

1 reference

A double-blind randomized placebo-controlled trial of sibutramine

31 March 2020

1 reference

Sibutramine reduces food intake in non-dieting women with obesity

31 March 2020

1 reference

A comparison of sibutramine and dexfenfluramine in the treatment of obesity

31 March 2020

1 reference

Biochemical and pharmacological characterisation of SR141716A, the first potent and selective brain cannabinoid receptor antagonist

31 March 2020

1 reference

Rimonabant for overweight or obesity

31 March 2020

1 reference

Safety, tolerability, pharmacokinetics, and pharmacodynamic properties of taranabant, a novel selective cannabinoid-1 receptor inverse agonist, for the treatment of obesity: results from a double-blind, placebo-controlled, single oral dose study in

31 March 2020

1 reference

Taranabant no longer developed as an antiobesity agent

31 March 2020

1 reference

Randomized placebo-controlled clinical trial of lorcaserin for weight loss in type 2 diabetes mellitus: the BLOOM-DM study

31 March 2020

1 reference

Identification of the 5-hydroxytryptamine2C receptor as a 60-kDa N-glycosylated protein in choroid plexus and hippocampus.

31 March 2020

1 reference

Glucose-6-phosphate dehydrogenase-derived NADPH fuels superoxide production in the failing heart

31 March 2020

1 reference

Upregulation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase activity increases oxidative stress in failing human heart

31 March 2020

1 reference

High fructose diet increases mortality in hypertensive rats compared to a complex carbohydrate or high fat diet

31 March 2020

1 reference

Long-term low-protein, low-calorie diet and endurance exercise modulate metabolic factors associated with cancer risk

31 March 2020

1 reference

Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial

31 March 2020

1 reference

Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin

31 March 2020

1 reference

A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse

31 March 2020

1 reference

Evidence that GABA in the nucleus dorsalis raphé induces stimulation of locomotor activity and eating behavior

31 March 2020

1 reference

Synaptic plasticity of feeding circuits: hormones and hysteresis

31 March 2020

1 reference

Deconstruction of a neural circuit for hunger

31 March 2020

1 reference

AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors

31 March 2020

1 reference

A one-year trial to assess the value of orlistat in the management of obesity

31 March 2020

1 reference

12 December 2020

Hypothalamic control of food intake in rats and cats

1 reference

12 December 2020

From the Centers for Disease Control and Prevention. Cardiac valvulopathy associated with exposure to fenfluramine or dexfenfluramine: US Department of Health and Human Services interim public health recommendations, November 1997

1 reference

12 December 2020

Obesity, diabetes, and neoplasia in yellow A(vy)/- mice: ectopic expression of the agouti gene

1 reference

12 December 2020

Mode of action of orlistat

1 reference

12 December 2020

Genetic aspects of severe childhood obesity

1 reference

12 December 2020

Food for thought. Dietary change was a driving force in human evolution.

1 reference

12 December 2020

Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy

1 reference

12 December 2020

Cetilistat, a new lipase inhibitor for the treatment of obesity.

1 reference

12 December 2020

Naltrexone SR/Bupropion SR (Contrave): A New Approach to Weight Loss in Obese Adults

1 reference

12 December 2020

Orlistat (Ro 18-0647), a lipase inhibitor, in the treatment of human obesity: a multiple dose study

1 reference

12 December 2020

Rimonabant for overweight or obesity

1 reference

12 December 2020