(Q38032488)

27 August 2017

title

Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis (English)

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27 August 2017

Shuangwei Li

1

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author name string

Diane DiFang Hsu

series ordinal

2

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27 August 2017

Hongyang Wang

series ordinal

3

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27 August 2017

Gen-Sheng Feng

series ordinal

4

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27 August 2017

publication date

6 August 2012

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27 August 2017

published in

Frontiers of medicine

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27 August 2017

volume

6

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27 August 2017

issue

3

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27 August 2017

page(s)

275-279

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Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew

27 August 2017

cites work

1 reference

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21 January 2018

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Crystal structure of the tyrosine phosphatase SHP-2

21 January 2018

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Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2

21 January 2018

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Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation

21 January 2018

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The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp

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A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion

21 January 2018

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Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation

21 January 2018

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Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

21 January 2018

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Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation

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Role of the SHP-2 tyrosine phosphatase in cytokine-induced signaling and cellular response

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PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase

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Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis

21 January 2018

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The tumor suppressor role of Src homology phosphotyrosine phosphatase 2 in hepatocellular carcinoma

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Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

21 January 2018

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PTPN11 mutations in LEOPARD syndrome

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Grouping of multiple-lentigines/LEOPARD and Noonan syndromes on the PTPN11 gene

21 January 2018

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Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation

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21 January 2018

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Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation.

21 January 2018

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Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.

21 January 2018

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A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase

21 January 2018

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An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival

21 January 2018

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Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism

21 January 2018

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21 January 2018

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Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia

21 January 2018

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Overexpression of Shp2 tyrosine phosphatase is implicated in leukemogenesis in adult human leukemia

21 January 2018

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Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis

21 January 2018

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Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.

21 January 2018

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Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells

21 January 2018

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Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis

21 January 2018

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21 January 2018

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A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells

21 January 2018

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21 January 2018

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Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool

21 January 2018

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Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells

21 January 2018

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Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection

21 January 2018

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21 January 2018

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21 January 2018

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Evolution of genomic instability in diethylnitrosamine-induced hepatocarcinogenesis in mice.

21 January 2018

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Juvenile myelomonocytic leukemia and Noonan syndrome

21 January 2018

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12 December 2020

Loss of Shp2 in alveoli epithelia induces deregulated surfactant homeostasis, resulting in spontaneous pulmonary fibrosis

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12 December 2020

Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration

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12 December 2020

Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin.

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12 December 2020

Spontaneous remission of juvenile chronic myelomonocytic leukemia in an infant with Noonan syndrome

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12 December 2020

The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp

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12 December 2020

Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homologue, SH-PTP2.

1 reference

12 December 2020

The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development

1 reference

12 December 2020

10.1007/S11684-012-0216-4

Identifiers

DOI

1 reference

Dimensions Publication ID

27 August 2017

1047835346

0 references

1 reference