(Q38036033)

27 August 2017

Hypoxia and hypoxia-inducible factors in glioblastoma multiforme progression and therapeutic implications (English)

1 reference

27 August 2017

0 references

1 reference

Liuqi Yang

1

1 reference

27 August 2017

Caiyu Lin

2

1 reference

27 August 2017

Li Wang

3

1 reference

27 August 2017

Huijie Guo

4

1 reference

27 August 2017

Xiujie Wang

5

1 reference

27 August 2017

language of work or name

English

0 references

publication date

13 August 2012

1 reference

Experimental Cell Research

27 August 2017

1 reference

27 August 2017

318

1 reference

27 August 2017

19

1 reference

27 August 2017

2417-2426

1 reference

The hypoxic proteome is influenced by gene-specific changes in mRNA translation

27 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

A novel extracellular Hsp90 mediated co-receptor function for LRP1 regulates EphA2 dependent glioblastoma cell invasion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Correlation of biological aggressiveness assessed by 11C-methionine PET and hypoxic burden assessed by 18F-fluoromisonidazole PET in newly diagnosed glioblastoma.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Grading of astrocytomas. A simple and reproducible method.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Adenosine modulates vascular endothelial growth factor expression via hypoxia-inducible factor-1 in human glioblastoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Hypoxia-inducible factor 1 as a possible target for cancer chemoprevention

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

NADPH oxidase subunit 4-mediated reactive oxygen species contribute to cycling hypoxia-promoted tumor progression in glioblastoma multiforme

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Malignant astrocytic glioma: genetics, biology, and paths to treatment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Identification of human brain tumour initiating cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Elevated invasive potential of glioblastoma stem cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Hypoxia--a key regulatory factor in tumour growth

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

The role of hypoxia-induced factors in tumor progression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Hypoxia-inducible factors, stem cells, and cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Hypoxia-inducible factor 1 regulated ARC expression mediated hypoxia induced inactivation of the intrinsic death pathway in p53 deficient human colon cancer cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

HIF1α regulated expression of XPA contributes to cisplatin resistance in lung cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

A model for the complex between the hypoxia-inducible factor-1 (HIF-1) and its consensus DNA sequence

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Targeting HIF-1 for cancer therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Hypoxia-inducible factor-1alpha blocks differentiation of malignant gliomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Knock down of HIF-1alpha in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

HIF-1 and tumor progression: pathophysiology and therapeutics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Hypoxia and the malignant glioma microenvironment: regulation and implications for therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Malignant glioma physiology: cellular response to hypoxia and its role in tumor progression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2alpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Inhibition of hypoxia inducible factor-1alpha (HIF-1alpha) decreases vascular endothelial growth factor (VEGF) secretion and tumor growth in malignant gliomas.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Angiogenesis and anti-angiogenic molecularly targeted therapies in malignant gliomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Angiogenesis: update 2005.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Hypoxia-mediated biological control

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Hypoxia-inducible factor 1 and cancer pathogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Brain tumor hypoxia: tumorigenesis, angiogenesis, imaging, pseudoprogression, and as a therapeutic target

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Expression of hypoxia-inducible factor 1? in brain tumors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Expression and distribution of vascular endothelial growth factor protein in human brain tumors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Vascular endothelial growth factor expression correlates with tumour grade and vascularity in gliomas.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Inhibition of Nodal suppresses angiogenesis and growth of human gliomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Angiogenesis in gliomas: biology and molecular pathophysiology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Meta-analysis of glioblastoma multiforme versus anaplastic astrocytoma identifies robust gene markers.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Genetic evidence for a tumor suppressor role of HIF-2alpha.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Modulation of carbonic anhydrase 9 (CA9) in human brain cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Receptor channel TRPC6 is a key mediator of Notch-driven glioblastoma growth and invasiveness.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Regulation of DNA repair mechanism in human glioma xenograft cells both in vitro and in vivo in nude mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Deadly teamwork: neural cancer stem cells and the tumor microenvironment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2 alpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

TGF-β Receptor Inhibitors Target the CD44(high)/Id1(high) Glioma-Initiating Cell Population in Human Glioblastoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Influence of oxygen tension on CD133 phenotype in human glioma cell cultures.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Making a tumour's bed: glioblastoma stem cells and the vascular niche.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Physiologic oxygen concentration enhances the stem-like properties of CD133+ human glioblastoma cells in vitro.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Tumor angiogenic and hypoxic profiles predict radiographic response and survival in malignant astrocytoma patients treated with bevacizumab and irinotecan

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

An ANOCEF genomic and transcriptomic microarray study of the response to radiotherapy or to alkylating first-line chemotherapy in glioblastoma patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Silencing of hypoxia inducible factor-1alpha by RNA interference attenuates human glioma cell growth in vivo.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Protocol of radiotherapy for glioblastoma according to the expression of HIF-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Evaluating hypoxia-inducible factor-1alpha as a cancer therapeutic target via inducible RNA interference in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Hypoxia in the tumorigenesis of gliomas and as a potential target for therapeutic measures

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Proteasomal inhibition attenuates transcriptional activity of hypoxia-inducible factor 1 (HIF-1) via specific effect on the HIF-1alpha C-terminal activation domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Amphotericin B blunts erythropoietin response to hypoxia by reinforcing FIH-mediated repression of HIF-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Molecular mechanisms of HIF-1alpha modulation induced by oxygen tension and BMP2 in glioblastoma derived cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Targeting cancer stem cells through L1CAM suppresses glioma growth

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromal-derived factor 1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

Overexpression of ZNF217 in glioblastoma contributes to the maintenance of glioma stem cells regulated by hypoxia-inducible factors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2012.07.017

10.1016/J.YEXCR.2012.07.017

7 January 2021

Identifiers

DOI

1 reference

27 August 2017

1 reference