(Q37174625)

18 August 2017

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title

Hypoxia-inducible factor 1 and cancer pathogenesis (English)

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18 August 2017

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1

Gregg L Semenza

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18 August 2017

publication date

1 September 2008

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18 August 2017

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18 August 2017

volume

60

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18 August 2017

issue

9

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18 August 2017

page(s)

591-597

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Tumor angiogenesis: therapeutic implications

18 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FIUB.93

Crossref

reference URL

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/20459

The Hallmarks of Cancer

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Molecular regulation of vessel maturation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Oxygen-dependent asparagine hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Targeting HIF-1 for cancer therapy

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

The interplay between MYC and HIF in cancer.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Hypoxia--a key regulatory factor in tumour growth

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Angiogenic inhibitors: a new therapeutic strategy in oncology

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Targeting hypoxia cell signaling for cancer therapy

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Signalling hypoxia by HIF hydroxylases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Hypoxia-dependent activation of HIF into a transcriptional regulator

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Tumor hypoxia and malignant progression.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Evaluation of HIF-1 inhibitors as anticancer agents

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Biology of hypoxia-inducible factor-2alpha in development and disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Why do cancers have high aerobic glycolysis?

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

HIF-dependent antitumorigenic effect of antioxidants in vivo

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/IUB.93

Identifiers

DOI

10.1002/IUB.93

1 reference

18 August 2017

1 reference