(Q38044425)

27 August 2017

title

Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease (English)

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27 August 2017

Patrick A Lewis

1

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Dario Alessi

object named as

Dario R Alessi

series ordinal

2

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publication date

1 October 2012

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Biochemical Society Transactions

27 August 2017

published in

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27 August 2017

volume

40

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27 August 2017

issue

5

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27 August 2017

page(s)

1039-1041

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

27 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

Genome-wide association study reveals genetic risk underlying Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

Genomewide association study of leprosy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

The leucine rich repeat kinase 2 (LRRK2) G2019S substitution mutation. Association with Parkinson disease, malignant melanoma and prevalence in ethnic groups in Israel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

LRRK2 and human disease: a complicated question or a question of complexes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

LRRK2 inhibition attenuates microglial inflammatory responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

Parkinson disease, cancer, and LRRK2: causation or association?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

Leucine-rich repeat kinase 2 gene-associated disease: redefining genotype-phenotype correlation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120178

21 January 2018

Identifiers

DOI

10.1042/BST20120178

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27 August 2017

1 reference