(Q38055447)

27 August 2017

title

With or without sugar? (A)glycosylation of therapeutic antibodies (English)

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27 August 2017

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Dmitrij Hristodorov

1

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27 August 2017

Rainer Fischer

series ordinal

2

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27 August 2017

Lars Linden

series ordinal

3

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27 August 2017

publication date

1 July 2013

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27 August 2017

published in

Molecular Biotechnology

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27 August 2017

volume

54

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27 August 2017

issue

3

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27 August 2017

page(s)

1056-1068

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https://scigraph.springernature.com/pub.10.1007/s12033-012-9612-x

27 August 2017

exact match

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Defucosylated chimeric anti-CC chemokine receptor 4 IgG1 with enhanced antibody-dependent cellular cytotoxicity shows potent therapeutic activity to T-cell leukemia and lymphoma

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Biopharmaceutical production in plants: problems, solutions and opportunities

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Methionine oxidation in human IgG2 Fc decreases binding affinities to protein A and FcRn

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Pharmacokinetics and antibody responses to the CD3 antibody otelixizumab used in the treatment of type 1 diabetes.

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The glycosylation of antibody molecules: functional significance.

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Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure

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12 December 2020

High-level accumulation of a recombinant antibody fragment in the periplasm of Escherichia coli requires a triple-mutant (degP prc spr) host strain

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Glycosylation of human IgG-Fc: influences on structure revealed by differential scanning micro-calorimetry

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Optimization of humanized IgGs in glycoengineered Pichia pastoris.

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Glycosylation influences on the aggregation propensity of therapeutic monoclonal antibodies

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High level production of functional antibody Fab fragments in an oxidizing bacterial cytoplasm

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Enhancement of the antibody-dependent cellular cytotoxicity of low-fucose IgG1 Is independent of FcgammaRIIIa functional polymorphism

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Glycan optimization of a human monoclonal antibody in the aquatic plant Lemna minor

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Effects of acid exposure on the conformation, stability, and aggregation of monoclonal antibodies.

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Characterization of a complex glycoprotein whose variable metabolic clearance in humans is dependent on terminal N-acetylglucosamine content

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Matrix metalloproteinase expression in the spondyloarthropathies

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Advances in Escherichia coli production of therapeutic proteins

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Formulation development of therapeutic monoclonal antibodies using high-throughput fluorescence and static light scattering techniques: role of conformational and colloidal stability

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12 December 2020

The structure of a neural specific carbohydrate epitope of horseradish peroxidase recognized by anti-horseradish peroxidase antiserum.

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12 December 2020

Immunoreactivity in mammals of two typical plant glyco-epitopes, core alpha(1,3)-fucose and core xylose.

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12 December 2020

IgG subclass-independent improvement of antibody-dependent cellular cytotoxicity by fucose removal from Asn297-linked oligosaccharides

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12 December 2020

Novel therapeutic inhibitors of the c-Met signaling pathway in cancer

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Pharmacokinetics/pharmacodynamics of nondepleting anti-CD4 monoclonal antibody (TRX1) in healthy human volunteers

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A nonfucosylated anti-HER2 antibody augments antibody-dependent cellular cytotoxicity in breast cancer patients

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Affinity purification of antibodies specific for Asn-linked glycans containing alpha 1-->3 fucose or beta 1-->2 xylose

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Production technologies for monoclonal antibodies and their fragments

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12 December 2020

Biosynthetic controls that determine the branching and microheterogeneity of protein-bound oligosaccharides

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12 December 2020

Detection of altered N-glycan profiles in whole serum from rheumatoid arthritis patients.

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12 December 2020

Enhanced natural killer cell binding and activation by low-fucose IgG1 antibody results in potent antibody-dependent cellular cytotoxicity induction at lower antigen density

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12 December 2020

Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors

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12 December 2020

Marketed therapeutic antibodies compendium

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12 December 2020

The asialoglycoprotein receptor: relationships between structure, function, and expression

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12 December 2020

Co-expression of human protein disulphide isomerase (PDI) can increase the yield of an antibody Fab' fragment expressed in Escherichia coli.

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12 December 2020

Chemical pathways of peptide degradation. I. Deamidation of adrenocorticotropic hormone

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12 December 2020

Glycosylation of recombinant antibody therapeutics

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12 December 2020

Crystallographic structure studies of an IgG molecule and an Fc fragment

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12 December 2020

The C-terminal KDEL sequence increases the expression level of a single-chain antibody designed to be targeted to both the cytosol and the secretory pathway in transgenic tobacco

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12 December 2020

Bypassing glycosylation: engineering aglycosylated full-length IgG antibodies for human therapy

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12 December 2020

Acid-induced aggregation of human monoclonal IgG1 and IgG2: molecular mechanism and the effect of solution composition.

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12 December 2020

In vivo deamidation characterization of monoclonal antibody by LC/MS/MS.

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12 December 2020

Folding mechanism of the CH2 antibody domain.

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12 December 2020

Mimicking the Escherichia coli cytoplasmic environment activates long-lived and efficient cell-free protein synthesis

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12 December 2020

Potent antibody therapeutics by design

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12 December 2020

Production of antibody fragments in Escherichia coli

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12 December 2020

Effect of glycosylation on antibody function: implications for genetic engineering

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12 December 2020

Immunoglobulin G specifically binding plant N-glycans with high affinity could be generated in rabbits but not in mice

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12 December 2020

FcγRs in health and disease.

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12 December 2020

Influence of pH on heat-induced aggregation and degradation of therapeutic monoclonal antibodies.

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12 December 2020

Levels of rheumatoid factor isotypes, metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 in synovial fluid from various arthritides

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12 December 2020

Ranibizumab, a mAb against VEGF-A for the potential treatment of age-related macular degeneration and other ocular complications.

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12 December 2020

CHO cells provide access to novel N-glycans and developmentally regulated glycosyltransferases

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12 December 2020

Assembly of asparagine-linked oligosaccharides

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12 December 2020

An antibody produced in tobacco expressing a hybrid beta-1,4-galactosyltransferase is essentially devoid of plant carbohydrate epitopes

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12 December 2020

Biosynthetic controls that determine the branching and microheterogeneity of protein-bound oligosaccharides

1 reference

12 December 2020

Aglycosylated chimeric mouse/human IgG1 antibody retains some effector function

1 reference

12 December 2020

Specificity of IgG and IgE antibodies against plant and insect glycoprotein glycans determined with artificial glycoforms of human transferrin

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12 December 2020

Fc glycans terminated with N-acetylglucosamine residues increase antibody resistance to papain

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12 December 2020

Monoclonal C5-1 antibody produced in transgenic alfalfa plants exhibits a N-glycosylation that is homogenous and suitable for glyco-engineering into human-compatible structures.

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12 December 2020

Effect of altered CH2-associated carbohydrate structure on the functional properties and in vivo fate of chimeric mouse-human immunoglobulin G1.

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12 December 2020

A novel role for the IgG Fc glycan: the anti-inflammatory activity of sialylated IgG Fcs.

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12 December 2020

Effect of posttranslational modifications on the thermal stability of a recombinant monoclonal antibody

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12 December 2020

The influence of glycosylation on the thermal stability and effector function expression of human IgG1-Fc: properties of a series of truncated glycoforms.

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12 December 2020

Selective clearance of glycoforms of a complex glycoprotein pharmaceutical caused by terminal N-acetylglucosamine is similar in humans and cynomolgus monkeys

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12 December 2020

Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity

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12 December 2020

Galactose-extended glycans of antibodies produced by transgenic plants

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12 December 2020

Impact of differential glycosylation on IgG activity

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12 December 2020

Glycoengineered Pichia produced anti-HER2 is comparable to trastuzumab in preclinical study.

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12 December 2020

Formatting antibody fragments to mediate specific therapeutic functions

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12 December 2020

Engineering Antibodies for Therapy

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12 December 2020

Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG Fc.

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12 December 2020

A phase II, double-blind, randomised, placebo-controlled study of BMS945429 (ALD518) in patients with rheumatoid arthritis with an inadequate response to methotrexate

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12 December 2020

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12 December 2020

Immunoglobulin G as a glycoprotein

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12 December 2020

The role of soluble aggregates in the primary immune response of mice to human gamma globulin

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12 December 2020

Recombinant antibody therapeutics: the impact of glycosylation on mechanisms of action

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12 December 2020

Aglycosylated antibodies and antibody fragments produced in a scalable in vitro transcription-translation system

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12 December 2020

PHASE I STUDY OF AN ENGINEERED AGLYCOSYLATED HUMANIZED CD3 ANTIBODY IN RENAL TRANSPLANT REJECTION1

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12 December 2020

Quantitative in vivo comparisons of the Fc gamma receptor-dependent agonist activities of different fucosylation variants of an immunoglobulin G antibody.

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of a chimeric/humanized anti-CD3 monoclonal antibody, otelixizumab (TRX4), in subjects with psoriasis and with type 1 diabetes mellitus

1 reference

12 December 2020

Monoclonal antibodies: versatile platforms for cancer immunotherapy

1 reference

12 December 2020

Engineering of therapeutic proteins production in Escherichia coli

1 reference

12 December 2020

Expression of GnTIII in a recombinant anti-CD20 CHO production cell line: Expression of antibodies with altered glycoforms leads to an increase in ADCC through higher affinity for FC gamma RIII.

1 reference

12 December 2020

Production of a monoclonal antibody in plants with a humanized N-glycosylation pattern.

1 reference

12 December 2020

Function and glycosylation of plant-derived antiviral monoclonal antibody

1 reference

12 December 2020

Cation exchange surface-mediated denaturation of an aglycosylated immunoglobulin (IgG1).

1 reference

12 December 2020

The periplasmic Escherichia coli peptidylprolyl cis,trans-isomerase FkpA. II. Isomerase-independent chaperone activity in vitro

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12 December 2020

Structure-function relationships in human immunoglobulins

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12 December 2020

Comparative studies of asparagine-linked sugar chains of immunoglobulin G from eleven mammalian species

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12 December 2020

Recombinant immunotherapeutics: current state and perspectives regarding the feasibility and market

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12 December 2020

Higher levels of sialylated Fc glycans in immunoglobulin G molecules can adversely impact functionality.

1 reference

12 December 2020

Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass.

1 reference

12 December 2020

A highly controllable reconstituted cell-free system--a breakthrough in protein synthesis research

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12 December 2020

Streamlining Escherichia coli S30 extract preparation for economical cell-free protein synthesis

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12 December 2020

Mannose receptor-mediated regulation of serum glycoprotein homeostasis

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12 December 2020

Production of complex human glycoproteins in yeast

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12 December 2020

Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types

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12 December 2020

Glycosylation as a strategy to improve antibody-based therapeutics

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12 December 2020

Plants as biofactories

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12 December 2020

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution

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12 December 2020

Antibody production with yeasts and filamentous fungi: on the road to large scale?

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12 December 2020

Multiple interactions of IgG with its core oligosaccharide can modulate recognition by complement and human Fc gamma receptor I and influence the synthesis of its oligosaccharide chains.

1 reference

12 December 2020

Engineering host cell lines to reduce terminal sialylation of secreted antibodies

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12 December 2020

Aglycosylated IgG variants expressed in bacteria that selectively bind FcgammaRI potentiate tumor cell killing by monocyte-dendritic cells

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12 December 2020

Protein aggregation and its inhibition in biopharmaceutics

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12 December 2020

Intracellular expression in pig cells of anti-alpha1,3galactosyltransferase single-chain FV antibodies reduces Gal alpha1,3Gal expression and inhibits cytotoxicity mediated by anti-Gal xenoantibodies.

1 reference

12 December 2020

In planta engineering of viral RNA replicons: efficient assembly by recombination of DNA modules delivered by Agrobacterium

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12 December 2020

Evolution of alpha 1,3galactosyltransferase and of the alpha-Gal epitope.

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12 December 2020

Generation and comparative characterization of glycosylated and aglycosylated human IgG1 antibodies

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12 December 2020

Antibodies to watch in 2010

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12 December 2020

Glycosylation in the Fc domain of IgG increases resistance to proteolytic cleavage by papain.

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12 December 2020

Neonatal Fc receptor and IgG-based therapeutics

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12 December 2020

Blood clearance in the rat of a recombinant mouse monoclonal antibody lacking the N-linked oligosaccharide side chains of the CH2 domains

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12 December 2020

Microscale to manufacturing scale-up of cell-free cytokine production--a new approach for shortening protein production development timelines

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12 December 2020

Sequences in antibody molecules important for receptor-mediated transport into the chicken egg yolk

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12 December 2020

Boosting heterologous protein production in transgenic dicotyledonous seeds using Phaseolus vulgaris regulatory sequences.

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12 December 2020

Structure of the murine unglycosylated IgG1 Fc fragment

1 reference

12 December 2020

Species-specific variation in glycosylation of IgG: evidence for the species-specific sialylation and branch-specific galactosylation and importance for engineering recombinant glycoprotein therapeutics

1 reference

12 December 2020

Effect of constant and variable domain glycosylation on pharmacokinetics of therapeutic antibodies in mice

1 reference

12 December 2020

Impact of methionine oxidation on the binding of human IgG1 to Fc Rn and Fc gamma receptors

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12 December 2020

Characterization of IgG1 conformation and conformational dynamics by hydrogen/deuterium exchange mass spectrometry

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12 December 2020

Cell-free synthesis of proteins that require disulfide bonds using glucose as an energy source.

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12 December 2020

Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity

1 reference

12 December 2020

Fucosylation of IgG heavy chains is increased in rheumatoid arthritis

1 reference

12 December 2020

Trends in glycosylation, glycoanalysis and glycoengineering of therapeutic antibodies and Fc-fusion proteins

1 reference

12 December 2020

10.1007/S12033-012-9612-X

Identifiers

DOI

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27 August 2017

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