(Q38056752)

27 August 2017

title

Cellular and animal indispensable amino acid limitation responses and health promotion. Can the two be linked? A critical review (English)

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27 August 2017

Angelos K Sikalidis

1

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27 August 2017

publication date

1 November 2012

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International Journal of Food Sciences and Nutrition

27 August 2017

published in

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27 August 2017

volume

64

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27 August 2017

issue

3

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27 August 2017

page(s)

300-311

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Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.

27 August 2017

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21 January 2018

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Localization of Rheb to the endomembrane is critical for its signaling function

21 January 2018

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GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.

21 January 2018

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The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase

21 January 2018

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Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders

21 January 2018

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Not all substrates are treated equally: implications for mTOR, rapamycin-resistance and cancer therapy

21 January 2018

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https://api.crossref.org/works/10.3109%2F09637486.2012.738649

mTOR, AMPK, and GCN2 coordinate the adaptation of hepatic energy metabolic pathways in response to protein intake in the rat.

21 January 2018

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https://api.crossref.org/works/10.3109%2F09637486.2012.738649

eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver

21 January 2018

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https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways

21 January 2018

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https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Molecular mechanisms of insulin resistance: serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: the two sides of a coin

21 January 2018

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eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

21 January 2018

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Amino acid sensing and mTOR regulation: inside or out?

21 January 2018

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https://api.crossref.org/works/10.3109%2F09637486.2012.738649

The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid.

21 January 2018

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https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex.

21 January 2018

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Regulated translation initiation controls stress-induced gene expression in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.3109%2F09637486.2012.738649

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

21 January 2018

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https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Translational regulation of GCN4 and the general amino acid control of yeast

21 January 2018

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https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Translational control in stress and apoptosis

21 January 2018

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https://api.crossref.org/works/10.3109%2F09637486.2012.738649

TRB3 inhibits the transcriptional activation of stress-regulated genes by a negative feedback on the ATF4 pathway.

21 January 2018

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https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Regulation of mRNA translation by protein folding in the endoplasmic reticulum

21 January 2018

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https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Nutritional control of gene expression: how mammalian cells respond to amino acid limitation

21 January 2018

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https://api.crossref.org/works/10.3109%2F09637486.2012.738649

ATF4-dependent transcription mediates signaling of amino acid limitation

21 January 2018

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Regulation of TORC1 by Rag GTPases in nutrient response

21 January 2018

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https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Eukaryotic initiation factor 2B and its role in alterations in mRNA translation that occur under a number of pathophysiological and physiological conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Hormesis and the antiaging action of dietary restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Role of hormesis in life extension by caloric restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

The low-methionine content of vegan diets may make methionine restriction feasible as a life extension strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Histology and survival in age-delayed low-tryptophan-fed rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2alpha protein kinase GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Activation of the ATF3 gene through a co-ordinated amino acid-sensing response programme that controls transcriptional regulation of responsive genes following amino acid limitation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Conducting the initiation of protein synthesis: the role of eIF4G.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Dual function of pancreatic endoplasmic reticulum kinase in tumor cell growth arrest and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

ER stress and hormetic regulation of the aging process

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Transcriptional control of cystine/glutamate transporter gene by amino acid deprivation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

TOR, a central controller of cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Elevated ATF4 expression, in the absence of other signals, is sufficient for transcriptional induction via CCAAT enhancer-binding protein-activating transcription factor response elements

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Growing rats respond to a sulfur amino acid-deficient diet by phosphorylation of the alpha subunit of eukaryotic initiation factor 2 heterotrimeric complex and induction of adaptive components of the integrated stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Regulation of antioxidant metabolism by translation initiation factor 2alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

MEK signaling is required for phosphorylation of eIF2alpha following amino acid limitation of HepG2 human hepatoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Stress-induced translation of ATF5 mRNA is regulated by the 5'-untranslated region

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Coping with stress: eIF2 kinases and translational control

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Tissue glutathione and cysteine levels in methionine-restricted rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

Nutritional control of aging

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F09637486.2012.738649

10.3109/09637486.2012.738649

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference