(Q38059491)

28 August 2017

Nonsense-mediated mRNA decay: from mechanistic insights to impacts on human health (English)

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28 August 2017

Isabel M Palacios

1

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28 August 2017

11 November 2012

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Briefings in functional genomics

28 August 2017

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28 August 2017

12

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28 August 2017

1

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28 August 2017

25-36

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Suppression of the nonsense mutation in homozygous beta 0 thalassaemia

28 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Interference of nonsense mutations with eukaryotic messenger RNA stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

RNA surveillance. Unforeseen consequences for gene expression, inherited genetic disorders and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Control of human beta-globin mRNA stability and its impact on beta-thalassemia phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

NMD: RNA biology meets human genetic medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

An unappreciated role for RNA surveillance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

A new function for nonsense-mediated mRNA-decay factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Nonsense-mediated mRNA decay and cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Nonsense-mediated mRNA decay and development: shoot the messenger to survive?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Aberrant growth and lethality of Arabidopsis deficient in nonsense-mediated RNA decay factors is caused by autoimmune-like response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Nonsense-mediated RNA decay: a molecular system micromanaging individual gene activities and suppressing genomic noise

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

T-cell receptor sequences that elicit strong down-regulation of premature termination codon-bearing transcripts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Unproductively spliced ribosomal protein mRNAs are natural targets of mRNA surveillance in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Alternative isoform regulation in human tissue transcriptomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Widespread predicted nonsense-mediated mRNA decay of alternatively-spliced transcripts of human normal and disease genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Boundary-independent polar nonsense-mediated decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

A faux 3'-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Posttranscriptional gene regulation by spatial rearrangement of the 3' untranslated region

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

The exon junction complex differentially marks spliced junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Splicing-dependent NMD does not require the EJC in Schizosaccharomyces pombe

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

A strategy for disease gene identification through nonsense-mediated mRNA decay inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated mRNA decay in colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Nonsense-mediated RNA decay regulation by cellular stress: implications for tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Ultraconserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

The multiple lives of NMD factors: balancing roles in gene and genome regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

High resolution transcriptome maps for wild-type and nonsense-mediated decay-defective Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Nonsense-mediated decay approaches the clinic

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

The nonsense-mediated decay RNA surveillance pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Execution of nonsense-mediated mRNA decay: what defines a substrate?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Interaction of PABPC1 with the translation initiation complex is critical to the NMD resistance of AUG-proximal nonsense mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Upf1 senses 3'UTR length to potentiate mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Nonsense-mediated mRNA decay in yeast does not require PAB1 or a poly(A) tail

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Assembly, disassembly and recycling: the dynamics of exon junction complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Drosophila mutants show NMD pathway activity is reduced, but not eliminated, in the absence of Smg6

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Cutting the nonsense: the degradation of PTC-containing mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Premature translational termination triggers mRNA decapping

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5' to 3' mRNA decay pathways in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Interactions between Upf1 and the decapping factors Edc3 and Pat1 in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Functions of the nonsense-mediated mRNA decay pathway in Drosophila development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

The human RNA surveillance factor UPF1 is required for S phase progression and genome stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

UPF1 involvement in nuclear functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

A meta-analysis of nonsense mutations causing human genetic disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Induction of tumour immunity by targeted inhibition of nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Does the nonsense-mediated mRNA decay mechanism prevent the synthesis of truncated BRCA1, CHK2, and p53 proteins?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

RNA surveillance is required for endoplasmic reticulum homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Identification of an additional gene required for eukaryotic nonsense mRNA turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

UPF2 is a critical regulator of liver development, function and regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

The nonsense-mediated decay pathway maintains synapse architecture and synaptic vesicle cycle efficacy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Introducing sense into nonsense in treatments of human genetic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

The structure and function of the rous sarcoma virus RNA stability element

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

smg mutants affect the expression of alternatively spliced SR protein mRNAs in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Sequential RNA degradation pathways provide a fail-safe mechanism to limit the accumulation of unspliced transcripts in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Autoregulation of the nonsense-mediated mRNA decay pathway in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

RNA homeostasis governed by cell type-specific and branched feedback loops acting on NMD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

An alternative branch of the nonsense-mediated decay pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

Hypoxic inhibition of nonsense-mediated RNA decay regulates gene expression and the integrated stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBFGP%2FELS051

21 January 2018

Identifiers

DOI

10.1093/BFGP/ELS051

1 reference

28 August 2017

1 reference

PubMed ID

23148322