(Q38062580)

28 August 2017

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title

The multiple origins of Type 1 diabetes (English)

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28 August 2017

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A Pugliese

1

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PubMed ID

23181718

28 August 2017

language of work or name

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1 February 2013

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28 August 2017

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28 August 2017

30

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28 August 2017

2

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28 August 2017

135-146

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Development of autoantibodies in the TrialNet Natural History Study

28 August 2017

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Diabetogenic T lymphocytes in human Type 1 diabetes

21 January 2018

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Genetics of type 1 diabetes: what's next?

21 January 2018

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Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY).

21 January 2018

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How thymic antigen presenting cells sample the body's self-antigens

21 January 2018

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Thymus-specific deletion of insulin induces autoimmune diabetes

21 January 2018

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The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

21 January 2018

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Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.

21 January 2018

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Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigen

21 January 2018

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Alternative splicing of G6PC2, the gene coding for the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), results in differential expression in human thymus and spleen compared with pancreas

21 January 2018

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Insulin gene VNTR genotype associates with frequency and phenotype of the autoimmune response to proinsulin

21 January 2018

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Projection of an immunological self shadow within the thymus by the aire protein

21 January 2018

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Insulin transactivator MafA regulates intrathymic expression of insulin and affects susceptibility to type 1 diabetes

21 January 2018

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Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs

21 January 2018

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NF-kappaB2 is required for the establishment of central tolerance through an Aire-dependent pathway

21 January 2018

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Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance.

21 January 2018

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Genetics of type 1 diabetes

21 January 2018

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Type 1 diabetes-associated HLA-DQ8 transdimer accommodates a unique peptide repertoire

21 January 2018

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Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes--indication of an increased environmental pressure?

21 January 2018

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The rising incidence of type 1 diabetes is accounted for by cases with lower-risk human leukocyte antigen genotypes

21 January 2018

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Trends in high-risk HLA susceptibility genes among Colorado youth with type 1 diabetes

21 January 2018

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Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk.

21 January 2018

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The changing epidemiology of type 1 diabetes: why is it going through the roof?

21 January 2018

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Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes

21 January 2018

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Register shifting of an insulin peptide-MHC complex allows diabetogenic T cells to escape thymic deletion

21 January 2018

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Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

21 January 2018

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Natural peptides selected by diabetogenic DQ8 and murine I-A(g7) molecules show common sequence specificity

21 January 2018

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Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

21 January 2018

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Self-reactive human CD4 T cell clones form unusual immunological synapses

21 January 2018

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Screening for novel lead compounds increasing insulin expression in medullary thymic epithelial cells

21 January 2018

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Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation

21 January 2018

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Reversal of autoimmunity by boosting memory-like autoregulatory T cells

21 January 2018

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Prevention of type 1 diabetes in the rat with an allele-specific anti-T-cell receptor antibody: Vβ13 as a therapeutic target and biomarker

21 January 2018

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Human peripheral lymphoid tissues contain autoimmune regulator-expressing dendritic cells

21 January 2018

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Deletional tolerance mediated by extrathymic Aire-expressing cells

21 January 2018

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Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation

21 January 2018

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Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions

21 January 2018

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Tissue- and age-specific changes in gene expression during disease induction and progression in NOD mice

21 January 2018

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Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes

21 January 2018

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Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases

21 January 2018

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Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes

21 January 2018

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Administration of CD4+CD25highCD127- regulatory T cells preserves β-cell function in type 1 diabetes in children

21 January 2018

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Protein tyrosine phosphatase PTPN22 in human autoimmunity

21 January 2018

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The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans

21 January 2018

1 reference

Change you can B(cell)eive in: recent progress confirms a critical role for B cells in type 1 diabetes

21 January 2018

1 reference

Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

21 January 2018

1 reference

Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.

21 January 2018

1 reference

Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function.

21 January 2018

1 reference

Interleukin-2 receptor signaling: at the interface between tolerance and immunity

21 January 2018

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Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

21 January 2018

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Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

21 January 2018

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IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

21 January 2018

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Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis

21 January 2018

1 reference

Interleukin-2 and regulatory T cells in graft-versus-host disease

21 January 2018

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Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function

21 January 2018

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Intermolecular antigen spreading occurs during the preclinical period of human type 1 diabetes

21 January 2018

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A sensitive method for detecting proliferation of rare autoantigen-specific human T cells

21 January 2018

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MHC multimers: expanding the clinical toolkit.

21 January 2018

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Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers.

21 January 2018

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Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients.

21 January 2018

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Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells.

21 January 2018

1 reference

Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill β-cells

21 January 2018

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Differentiation, expansion, and homeostasis of autoreactive T cells in type 1 diabetes mellitus

21 January 2018

1 reference

GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes

21 January 2018

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Islet autoantibodies as potential markers for disease recurrence in clinical islet transplantation

21 January 2018

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Differences in baseline lymphocyte counts and autoreactivity are associated with differences in outcome of islet cell transplantation in type 1 diabetic patients

21 January 2018

1 reference

Immunology in the clinic review series; focus on type 1 diabetes and viruses: the enterovirus link to type 1 diabetes: critical review of human studies

21 January 2018

1 reference

Maternal enterovirus infection as a risk factor for type 1 diabetes in the exposed offspring

21 January 2018

1 reference

Immunology in the clinic review series; focus on type 1 diabetes and viruses: enterovirus, thymus and type 1 diabetes pathogenesis

21 January 2018

1 reference

The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes.

21 January 2018

1 reference

Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients

21 January 2018

1 reference

Immunohistochemical analysis of the relationship between islet cell proliferation and the production of the enteroviral capsid protein, VP1, in the islets of patients with recent-onset type 1 diabetes

21 January 2018

1 reference

Interferon induced with helicase C domain 1 (IFIH1) and virus-induced autoimmunity: a review

21 January 2018

1 reference

Immunology in the Clinic Review Series; focus on metabolic diseases: development of islet autoimmune disease in type 2 diabetes patients: potential sequelae of chronic inflammation

21 January 2018

1 reference

Latent autoimmune diabetes in adults (LADA) should be less latent

21 January 2018

1 reference

Clinical review: Type 1 diabetes and latent autoimmune diabetes in adults: one end of the rainbow

21 January 2018

1 reference

Can the genetics of type 1 and type 2 diabetes shed light on the genetics of latent autoimmune diabetes in adults?

21 January 2018

1 reference

T-cell responses to islet antigens improves detection of autoimmune diabetes and identifies patients with more severe beta-cell lesions in phenotypic type 2 diabetes.

21 January 2018

1 reference

Prevalence of overweight and obesity in youth with diabetes in USA: the SEARCH for Diabetes in Youth study

21 January 2018

1 reference

Addressing insulin resistance in Type 1 diabetes.

21 January 2018

1 reference

Insulin resistance is a risk factor for progression to type 1 diabetes

21 January 2018

1 reference

Five stages of evolving beta-cell dysfunction during progression to diabetes

21 January 2018

1 reference

Testing the accelerator hypothesis: body size, beta-cell function, and age at onset of type 1 (autoimmune) diabetes

21 January 2018

1 reference

Insulin resistance and progression to type 1 diabetes in the European Nicotinamide Diabetes Intervention Trial (ENDIT).

21 January 2018

1 reference

Progression to diabetes in relatives of type 1 diabetic patients: mechanisms and mode of onset

21 January 2018

1 reference

Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes

21 January 2018

1 reference

Age- and islet autoimmunity-associated differences in amino acid and lipid metabolites in children at risk for type 1 diabetes

21 January 2018

1 reference

The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines

21 January 2018

1 reference

Type 1 diabetes is associated with enterovirus infection in gut mucosa

21 January 2018

1 reference

Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes

21 January 2018

1 reference

Expression and regulation of chemokines in murine and human type 1 diabetes.

21 January 2018

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Dysregulated Toll-like receptor-induced interleukin-1β and interleukin-6 responses in subjects at risk for the development of type 1 diabetes

21 January 2018

1 reference

The gut mucosa as a site for induction of regulatory T-cells

21 January 2018

1 reference

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

21 January 2018

1 reference

Synergistic reversal of type 1 diabetes in NOD mice with anti-CD3 and interleukin-1 blockade: evidence of improved immune regulation

21 January 2018

1 reference

The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants

21 January 2018

1 reference

Modeling dynamic changes in type 1 diabetes progression: quantifying beta-cell variation after the appearance of islet-specific autoimmune responses

21 January 2018

1 reference

Intravital imaging of CTLs killing islet cells in diabetic mice

21 January 2018

1 reference

Following the fate of one insulin-reactive CD4 T cell: conversion into Teffs and Tregs in the periphery controls diabetes in NOD mice

21 January 2018

1 reference

Detection of β cell death in diabetes using differentially methylated circulating DNA.

21 January 2018

1 reference

Patterns of metabolic progression to type 1 diabetes in the Diabetes Prevention Trial-Type 1.

21 January 2018

1 reference

Glucose excursions between states of glycemia with progression to type 1 diabetes in the diabetes prevention trial-type 1 (DPT-1).

21 January 2018

1 reference

The rise and fall of insulin secretion in type 1 diabetes mellitus

21 January 2018

1 reference

Preservation of beta-cell function in autoantibody-positive youth with diabetes

21 January 2018

1 reference

Fall in C-peptide during first 2 years from diagnosis: evidence of at least two distinct phases from composite Type 1 Diabetes TrialNet data

21 January 2018

1 reference

Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?

21 January 2018

1 reference

Residual insulin production and pancreatic ß-cell turnover after 50 years of diabetes: Joslin Medalist Study.

21 January 2018

1 reference

Extent of beta cell destruction is important but insufficient to predict the onset of type 1 diabetes mellitus

21 January 2018

1 reference

Insulitis in human type 1 diabetes: The quest for an elusive lesion

21 January 2018

1 reference

Stopping type 1 diabetes: attempts to prevent or cure type 1 diabetes in man.

21 January 2018

1 reference

Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes

21 January 2018

1 reference

Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/DME.12081

1 reference

release_ifuhu4hoibgjpgqevtzg56qgoa

28 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ifuhu4hoibgjpgqevtzg56qgoa

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

23181718

1 reference

PubMed ID

23181718