(Q38072077)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23294027%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

review article

1 reference

title

Improving the prediction of drug disposition in the brain (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23294027%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23294027%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

author name string

Pranas Japertas

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23294027%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Remigijus Didziapetris

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23294027%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

language of work or name

English

0 references

publication date

8 January 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23294027%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Drug Metabolism & Toxicology

21 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23294027%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23294027%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23294027%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

page(s)

473-486

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23294027%20AND%20SRC:MED&resulttype=core&format=json

In vivo, in vitro and in silico methods for small molecule transfer across the BBB.

21 February 2020

cites work

1 reference

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Structure and function of the blood-brain barrier

21 January 2018

1 reference

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Strategies to minimize CNS toxicity: in vitro high-throughput assays and computational modeling

21 January 2018

1 reference

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Quinolones: review of psychiatric and neurological adverse reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Neurotoxic effects associated with antibiotic use: management considerations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Approaches to seizure risk assessment in preclinical drug discovery.

21 January 2018

1 reference

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Central nervous system complications of cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

In silico predictions of blood-brain barrier penetration: considerations to "keep in mind".

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

On the rate and extent of drug delivery to the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Challenges for blood-brain barrier (BBB) screening

21 January 2018

1 reference

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Significance of protein binding in pharmacokinetics and pharmacodynamics

21 January 2018

1 reference

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Computational prediction of the plasma protein-binding percent of diverse pharmaceutical compounds

21 January 2018

1 reference

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How to measure drug transport across the blood-brain barrier

21 January 2018

1 reference

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Comparison of blood-brain barrier permeability assays: in situ brain perfusion, MDR1-MDCKII and PAMPA-BBB.

21 January 2018

1 reference

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Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases.

21 January 2018

1 reference

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Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Full efficacy with no CNS side-effects: unachievable panacea or reality? DMPK considerations in design of drugs with limited brain penetration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Efflux transporters in the blood-brain interfaces--in vitro and in vivo methods and correlations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Drug entry into the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Molecular factors influencing drug transfer across the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Hydrogen bonding. 33. Factors that influence the distribution of solutes between blood and brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

The factors that influence permeation across the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Development of a computational approach to predict blood-brain barrier permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Development of an in situ mouse brain perfusion model and its application to mdr1a P-glycoprotein-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Ionization-specific prediction of blood-brain permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Ionization-specific analysis of human intestinal absorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

P-glycoprotein deficient mouse in situ blood-brain barrier permeability and its prediction using an in combo PAMPA model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Physicochemical selectivity of the BBB microenvironment governing passive diffusion--matching with a porcine brain lipid extract artificial membrane permeability model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

The permeation of neutral molecules, ions, and ionic species through membranes: brain permeation as an example.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Equations for the transfer of neutral molecules and ionic species from water to organic phases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Central nervous system drug disposition: the relationship between in situ brain permeability and brain free fraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Computational approaches to the prediction of the blood-brain distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Recent advances in the prediction of blood-brain partitioning from molecular structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

In silico prediction of blood–brain barrier permeation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Brain drug targeting: a computational approach for overcoming blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

A data base for partition of volatile organic compounds and drugs from blood/plasma/serum to brain, and an LFER analysis of the data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Water-solvent partition coefficients and Delta Log P values as predictors for blood-brain distribution; application of the Akaike information criterion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Predicting blood-brain barrier penetration from molecular weight and number of polar atoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Prediction of blood-brain distribution: effect of ionization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

In silico prediction of blood brain barrier permeability: an Artificial Neural Network model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

QSAR modeling of the blood-brain barrier permeability for diverse organic compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

New predictive models for blood-brain barrier permeability of drug-like molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

A prediction model for blood-brain barrier permeation and analysis on its parameter biologically

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Insights for predicting blood-brain barrier penetration of CNS targeted molecules using QSPR approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Qualitative prediction of blood-brain barrier permeability on a large and refined dataset

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Best Practices for QSAR Model Development, Validation, and Exploitation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Small molecular drug transfer across the blood-brain barrier via carrier-mediated transport systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Use of plasma and brain unbound fractions to assess the extent of brain distribution of 34 drugs: comparison of unbound concentration ratios to in vivo p-glycoprotein efflux ratios

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

The highly permeable blood-brain barrier: an evaluation of current opinions about brain uptake capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Assessment of the blood-brain barrier in CNS drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Addressing central nervous system (CNS) penetration in drug discovery: basics and implications of the evolving new concept

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

How well do lipophilicity parameters, MEEKC microemulsion capacity factor, and plasma protein binding predict CNS tissue binding?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

In silico prediction of unbound brain-to-plasma concentration ratio using machine learning algorithms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Blood-brain barrier permeation models: discriminating between potential CNS and non-CNS drugs including P-glycoprotein substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Predicting penetration across the blood-brain barrier from simple descriptors and fragmentation schemes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Prediction of passive blood-brain partitioning: straightforward and effective classification models based on in silico derived physicochemical descriptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Ionization-specific QSAR models of blood-brain penetration of drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Use of a physiologically based pharmacokinetic model to study the time to reach brain equilibrium: an experimental analysis of the role of blood-brain barrier permeability, plasma protein binding, and brain tissue binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Progress in brain penetration evaluation in drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Computational prediction of blood-brain barrier permeability using decision tree induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

A Bayesian approach to in silico blood-brain barrier penetration modeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

The blood-brain barrier: bottleneck in brain drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Which in vitro screens guide the prediction of oral absorption and volume of distribution?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Molecular properties that influence the oral bioavailability of drug candidates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Classification analysis of P-glycoprotein substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

Development and validation of a pharmacophore-based QSAR model for the prediction of CNS activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2013.754423

10.1517/17425255.2013.754423

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23294027%20AND%20SRC:MED&resulttype=core&format=json

release_ahfz3nw2bjgtzl6bimryuzghvu

21 February 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ahfz3nw2bjgtzl6bimryuzghvu

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference