(Q38074014)

28 August 2017

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title

The mutant p53 mouse as a pre-clinical model (English)

1 reference

28 August 2017

J G Jackson

1

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28 August 2017

G Lozano

series ordinal

2

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28 August 2017

language of work or name

English

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publication date

14 January 2013

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28 August 2017

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28 August 2017

32

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28 August 2017

4325-4330

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28 August 2017

37

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https://scigraph.springernature.com/pub.10.1038/onc.2012.610

28 August 2017

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cites work

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TP53 mutations in human cancer: database reassessment and prospects for the next decade

21 January 2018

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Transcriptional control of human p53-regulated genes

21 January 2018

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Timeline: Chemotherapy and the war on cancer.

21 January 2018

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Intrinsic tumour suppression

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.610

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.610

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.610

p53 mutation heterogeneity in cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.610

Restoration of p53 function leads to tumour regression in vivo

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.610

Modeling the therapeutic efficacy of p53 restoration in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.610

Temporal dissection of p53 function in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Selective activation of p53-mediated tumour suppression in high-grade tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Stage-specific sensitivity to p53 restoration during lung cancer progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Tumor suppression by Ink4a-Arf: progress and puzzles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Multiple stress signals activate mutant p53 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Cancer. p53, guardian of the genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

p53 is required for radiation-induced apoptosis in mouse thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Thymocyte apoptosis induced by p53-dependent and independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

DNA and its associated processes as targets for cancer therapy

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.610

Predicting response to cancer chemotherapy: the role of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Chronic lymphocytic leukemia and treatment resistance in cancer: the role of the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

TP53 status and response to chemotherapy in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Genetic analysis of chemoresistance in primary murine lymphomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

The ups and downs of p53 regulation in hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Breast cancer molecular subtypes respond differently to preoperative chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Effect of mutated TP53 on response of advanced breast cancers to high-dose chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

A CXCL1 paracrine network links cancer chemoresistance and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Chemokine signaling via the CXCR2 receptor reinforces senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Molecular mechanisms of tumor suppression by LKB1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Response and resistance to NF-κB inhibitors in mouse models of lung adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

p53-dependent apoptosis suppresses tumor growth and progression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Genetic determinants of response to chemotherapy in transgenic mouse mammary and salivary tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Chemokine networks and breast cancer metastasis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

Cell-cycle arrest versus cell death in cancer therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.610

31 March 2020

Identifiers

DOI

10.1038/ONC.2012.610

1 reference

Dimensions Publication ID

28 August 2017

0 references

1 reference