(Q38074493)

28 August 2017

1 reference

title

Targeting endoplasmic reticulum stress in metabolic disease (English)

1 reference

28 August 2017

endoplasmic reticulum

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author name string

Stewart Siyan Cao

series ordinal

1

1 reference

PubMed ID

23324104

28 August 2017

Randal J Kaufman

series ordinal

2

1 reference

PubMed ID

23324104

28 August 2017

language of work or name

English

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publication date

17 January 2013

1 reference

Expert Opinion on Therapeutic Targets

28 August 2017

1 reference

28 August 2017

17

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28 August 2017

4

1 reference

28 August 2017

437-448

1 reference

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

28 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Unfolded protein response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Endoplasmic reticulum stress and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

The impact of the unfolded protein response on human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

The unfolded protein response: from stress pathway to homeostatic regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Signal integration in the endoplasmic reticulum unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Endoplasmic reticulum protein BI-1 regulates Ca²⁺-mediated bioenergetics to promote autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Dominant-Negative Effects of a Novel Mutated Ins2 Allele Causes Early-Onset Diabetes and Severe -Cell Loss in Munich Ins2C95S Mutant Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Association of amino acid variants in the activating transcription factor 6 gene (ATF6) on 1q21-q23 with type 2 diabetes in Pima Indians

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Atf6α-null mice are glucose intolerant due to pancreatic β-cell failure on a high-fat diet but partially resistant to diet-induced insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

New insights into ER stress-induced insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Aberrant hepatic TRIB3 gene expression in insulin-resistant obese humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

From endoplasmic-reticulum stress to the inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Endoplasmic reticulum stress in liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

A point mutation in Sec61alpha1 leads to diabetes and hepatosteatosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Macrophages in the pathogenesis of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Endoplasmic reticulum Ca2+ depletion induces endothelial cell apoptosis independently of caspase-12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Free cholesterol overloading induced smooth muscle cells death and activated both ER- and mitochondrial-dependent death pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Role of endoplasmic reticulum stress in metabolic disease and other disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Chemical chaperones mediate increased secretion of mutant alpha 1-antitrypsin (alpha 1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in alpha 1-AT deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Endoplasmic reticulum stress plays a central role in development of leptin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Valproate protects the retina from endoplasmic reticulum stress-induced apoptosis after ischemia-reperfusion injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Valproate attenuates accelerated atherosclerosis in hyperglycemic apoE-deficient mice: evidence in support of a role for endoplasmic reticulum stress and glycogen synthase kinase-3 in lesion development and hepatic steatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

A molecular chaperone inducer protects neurons from ER stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Post-treatment of a BiP inducer prevents cell death after middle cerebral artery occlusion in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Structural determinants of PERK inhibitor potency and selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (P

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

The dsRNA protein kinase PKR: virus and cell control

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Small molecule inhibitors of the RNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Inhibitor of double stranded RNA-dependent protein kinase protects against cell damage induced by ER stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Suppression of PKR promotes network excitability and enhanced cognition by interferon-γ-mediated disinhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Potent and selective inhibitors of the inositol-requiring enzyme 1 endoribonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Peptides derived from the bifunctional kinase/RNase enzyme IRE1α modulate IRE1α activity and protect cells from endoplasmic reticulum stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Chemical biology investigation of cell death pathways activated by endoplasmic reticulum stress reveals cytoprotective modulators of ASK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Chemical and/or biological therapeutic strategies to ameliorate protein misfolding diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Endoplasmic reticulum Ca2+ increases enhance mutant glucocerebrosidase proteostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Antioxidants reduce endoplasmic reticulum stress and improve protein secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Animal and human studies with the mitochondria-targeted antioxidant MitoQ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Mitochondria-targeted antioxidants protect pancreatic β-cells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Macrophage autophagy plays a protective role in advanced atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

Role of the unfolded protein response regulator GRP78/BiP in development, cancer, and neurological disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.756471

10.1517/14728222.2013.756471

21 January 2018

Identifiers

DOI

1 reference

28 August 2017

1 reference

PubMed ID

23324104