(Q38075897)

28 August 2017

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title

mGlu5 negative allosteric modulators: a patent review (2010-2012). (English)

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28 August 2017

Kyle A Emmitte

1

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28 August 2017

language of work or name

English

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publication date

22 January 2013

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Expert Opinion on Therapeutic Patents

28 August 2017

published in

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28 August 2017

volume

23

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28 August 2017

issue

4

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28 August 2017

page(s)

393-408

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Pharmacological agents acting at subtypes of metabotropic glutamate receptors

28 August 2017

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21 January 2018

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A combined marble burying-locomotor activity test in mice: a practical screening test with sensitivity to different classes of anxiolytics and antidepressants.

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Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP.

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CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor

21 January 2018

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Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice.

21 January 2018

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Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP.

21 January 2018

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Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism

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21 January 2018

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Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice

21 January 2018

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21 January 2018

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Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking

21 January 2018

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Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking

21 January 2018

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Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications

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Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats

21 January 2018

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Antagonism at metabotropic glutamate 5 receptors inhibits nicotine- and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking

21 January 2018

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21 January 2018

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21 January 2018

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Comparison of the effects of mGluR1 and mGluR5 antagonists on the expression of behavioral sensitization to the locomotor effect of morphine and the morphine withdrawal jumping in mice

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Cue-induced reinstatement of alcohol-seeking behavior is associated with increased ERK1/2 phosphorylation in specific limbic brain regions: blockade by the mGluR5 antagonist MPEP

21 January 2018

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Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties.

21 January 2018

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Treatment of anxiety using fenobam (a nonbenzodiazepine) in a double-blind standard (diazepam) placebo-controlled study

21 January 2018

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A pilot open label, single dose trial of fenobam in adults with fragile X syndrome.

21 January 2018

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A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Glutamatergic fine tuning with ADX-10059: a novel therapeutic approach for migraine?

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development

21 January 2018

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Molecular and functional characterization of recombinant human metabotropic glutamate receptor subtype 5.

21 January 2018

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Nicotine reduces levodopa-induced dyskinesias in lesioned monkeys

21 January 2018

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Continuous and intermittent nicotine treatment reduces L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesias in a rat model of Parkinson's disease

21 January 2018

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JN403, in vitro characterization of a novel nicotinic acetylcholine receptor alpha7 selective agonist.

21 January 2018

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[(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5.

21 January 2018

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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

21 January 2018

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[3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor

21 January 2018

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A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.

21 January 2018

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Evaluation of marble-burying behavior as a model of anxiety.

21 January 2018

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Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test

21 January 2018

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Design, Synthesis, and Structure−Activity Relationships of Novel Bicyclic Azole-amines as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5

21 January 2018

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Digging and marble burying in mice: simple methods for in vivo identification of biological impacts.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Glutamate receptors in pediatric tumors of the central nervous system

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2013.760544

mGlu Receptors and Cancerous Growth

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2013.760544

N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors

21 January 2018

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10.1517/13543776.2013.760544

21 January 2018

Identifiers

DOI

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28 August 2017

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