(Q38075897)

28 August 2017

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title

mGlu5 negative allosteric modulators: a patent review (2010-2012). (English)

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28 August 2017

Kyle A Emmitte

1

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28 August 2017

language of work or name

English

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publication date

22 January 2013

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Expert Opinion on Therapeutic Patents

28 August 2017

published in

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28 August 2017

volume

23

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28 August 2017

issue

4

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28 August 2017

page(s)

393-408

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Pharmacological agents acting at subtypes of metabotropic glutamate receptors

28 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Pharmacology and functions of metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

How many drug targets are there?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Target validation of G-protein coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Metabotropic glutamate receptors: novel targets for drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

G-protein-coupled receptors: from classical modes of modulation to allosteric mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

New therapeutic frontiers for metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Molecular pharmacology and therapeutic prospects of metabotropic glutamate receptor allosteric modulators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Positive and negative allosteric modulation of metabotropic glutamate receptors: emerging therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Recent advances in the design and development of novel negative allosteric modulators of mGlu(5)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

mGluR5 negative allosteric modulators overview: a medicinal chemistry approach towards a series of novel therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Anxiolytic-like effects of MTEP, a potent and selective mGlu5 receptor agonist does not involve GABA(A) signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

A combined marble burying-locomotor activity test in mice: a practical screening test with sensitivity to different classes of anxiolytics and antidepressants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Transient lower esophageal sphincter relaxations in dogs are inhibited by a metabotropic glutamate receptor 5 antagonist.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Inhibition of transient lower esophageal sphincter relaxation and gastroesophageal reflux by metabotropic glutamate receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Effect of the metabotropic glutamate receptor type 5 antagonists MPEP and MTEP in parkinsonian monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

The mGluR5 antagonist MPEP reduces the conditioned rewarding effects of cocaine but not other drugs of abuse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Dissociation of the effects of MTEP [3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine] on conditioned reinstatement and reinforcement: comparison between cocaine and a conventional reinforcer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Antagonism at metabotropic glutamate 5 receptors inhibits nicotine- and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Attenuation of cocaine self-administration in squirrel monkeys following repeated administration of the mGluR5 antagonist MPEP: comparison with dizocilpine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Attenuation of behavioral effects of cocaine by the Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: comparison with dizocilpine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

The effects of the mGluR5 receptor antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) on behavioural responses to nicotine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Comparison of the effects of mGluR1 and mGluR5 antagonists on the expression of behavioral sensitization to the locomotor effect of morphine and the morphine withdrawal jumping in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

mGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Cue-conditioned alcohol seeking in rats following abstinence: involvement of metabotropic glutamate 5 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Interoceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Role of protein kinase C epsilon (PKCvarepsilon) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Cue-induced reinstatement of alcohol-seeking behavior is associated with increased ERK1/2 phosphorylation in specific limbic brain regions: blockade by the mGluR5 antagonist MPEP

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Treatment of anxiety using fenobam (a nonbenzodiazepine) in a double-blind standard (diazepam) placebo-controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

A pilot open label, single dose trial of fenobam in adults with fragile X syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Glutamatergic fine tuning with ADX-10059: a novel therapeutic approach for migraine?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ056.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Molecular and functional characterization of recombinant human metabotropic glutamate receptor subtype 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Nicotine reduces levodopa-induced dyskinesias in lesioned monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Continuous and intermittent nicotine treatment reduces L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesias in a rat model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

JN403, in vitro characterization of a novel nicotinic acetylcholine receptor alpha7 selective agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

[(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

[3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Evaluation of marble-burying behavior as a model of anxiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Design, Synthesis, and Structure−Activity Relationships of Novel Bicyclic Azole-amines as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Digging and marble burying in mice: simple methods for in vivo identification of biological impacts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

Glutamate receptors in pediatric tumors of the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

mGlu Receptors and Cancerous Growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2013.760544

10.1517/13543776.2013.760544

21 January 2018

Identifiers

DOI

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28 August 2017

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