(Q38082329)

28 August 2017

Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal? (English)

1 reference

28 August 2017

cardiovascular disease

1 reference

John Pernow

1

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author name string

Christian Jung

series ordinal

2

1 reference

28 August 2017

14 February 2013

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28 August 2017

Cardiovascular Research

1 reference

28 August 2017

98

1 reference

28 August 2017

3

1 reference

28 August 2017

334-343

1 reference

Endothelial function and dysfunction. Part II: Association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension

28 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

The physiology and pathophysiology of the nitric oxide/superoxide system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Arginase: a critical regulator of nitric oxide synthesis and vascular function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Arginase inhibition increases nitric oxide production in bovine pulmonary arterial endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

MKP-1 switches arginine metabolism from nitric oxide synthase to arginase following endotoxin challenge.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Arginase: an emerging key player in the mammalian immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Oxidized low-density lipoprotein-dependent endothelial arginase II activation contributes to impaired nitric oxide signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Diabetes-induced coronary vascular dysfunction involves increased arginase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Hypoxia promotes human pulmonary artery smooth muscle cell proliferation through induction of arginase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

p38 Mitogen-activated protein kinase (MAPK) increases arginase activity and contributes to endothelial dysfunction in corpora cavernosa from angiotensin-II-treated mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Upregulation of arginase by H2O2 impairs endothelium-dependent nitric oxide-mediated dilation of coronary arterioles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Oxidative species increase arginase activity in endothelial cells through the RhoA/Rho kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Arginase activity mediates retinal inflammation in endotoxin-induced uveitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

The involvement of tyrosine kinases, cyclic AMP/protein kinase A, and p38 mitogen-activated protein kinase in IL-13-mediated arginase I induction in macrophages: its implications in IL-13-inhibited nitric oxide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Inducible NO synthase dependent S-nitrosylation and activation of arginase1 contribute to age-related endothelial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

OxLDL-dependent activation of arginase II is dependent on the LOX-1 receptor and downstream RhoA signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Endothelial dysfunction in hypertension: the role of arginase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Arginase and vascular aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Nitric oxide synthases: regulation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Atherosclerosis — An Inflammatory Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Endothelial dysfunction: a marker of atherosclerotic risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Endothelial arginase II: a novel target for the treatment of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Arginase activities and global arginine bioavailability in wild-type and ApoE-deficient mice: responses to high fat and high cholesterol diets

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Modulating role of estradiol on arginase II expression in hyperlipidemic rabbits as an atheroprotective mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Direct vascular effects of HMG-CoA reductase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Oxidized low-density lipoprotein inhibits nitric oxide-mediated coronary arteriolar dilation by up-regulating endothelial arginase I

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Macrophage plasticity in experimental atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Endothelial arginase: a new target in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Elevated arginase I expression in rat aortic smooth muscle cells increases cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Arginase promotes neointima formation in rat injured carotid arteries

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Arginine/arginase NO NO NO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Arginase inhibition mediates cardioprotection during ischaemia-reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Local arginase inhibition during early reperfusion mediates cardioprotection via increased nitric oxide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

TNF-alpha contributes to endothelial dysfunction by upregulating arginase in ischemia/reperfusion injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Involvement of the ornithine decarboxylase/polyamine system in precondition-induced cardioprotection through an interaction with PKC in rat hearts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Genomic biomarkers and cellular pathways of ischemic stroke by RNA gene expression profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Melatonin ameliorates cerebral vasospasm after experimental subarachnoidal haemorrhage correcting imbalance of nitric oxide levels in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Impact of arginase II on CBF in experimental cortical impact injury in mice using MRI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Arginase II deletion increases corpora cavernosa relaxation in diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

The phenotype and functional alterations of macrophages in mice with hyperglycemia for long term.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Insulin reduces plasma arginase activity in type 2 diabetic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Diabetes-induced vascular dysfunction involves arginase I

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

The role of arginase I in diabetes-induced retinal vascular dysfunction in mouse and rat models of diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Mechanisms of dysfunction of the nitric oxide pathway in vascular diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Increased inducible nitric oxide synthase and arginase II expression in heart failure: no net nitrite/nitrate production and protein S-nitrosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Modulation of contractility by myocyte-derived arginase in normal and hypertrophied feline myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Low arginine/asymmetric dimethylarginine ratio deteriorates systemic hemodynamics and organ blood flow in a rat model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Arginase inhibition restores arteriolar endothelial function in Dahl rats with salt-induced hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arterioles

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Misregulation of the arginase pathway in tissues of spontaneously hypertensive rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Treatment with the arginase inhibitor N(omega)-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Arginase II knockout mouse displays a hypertensive phenotype despite a decreased vasoconstrictory profile.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Endothelial NO synthase activity in nucleus tractus solitarii contributes to hypertension in spontaneously hypertensive rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Up-regulation of arginase activity contributes to attenuated reflex cutaneous vasodilatation in hypertensive humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Nitrite in pulmonary arterial hypertension: therapeutic avenues in the setting of dysregulated arginine/nitric oxide synthase signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Up-regulation of arginase II contributes to pulmonary vascular endothelial cell dysfunction during experimental pulmonary embolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Arginase depletes plasma l-arginine and decreases pulmonary vascular reserve during experimental pulmonary embolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Hypoxic upregulation of arginase II in human lung endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

L-arginine plasma levels and severity of idiopathic pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Arginase Reciprocally Regulates Nitric Oxide Synthase Activity and Contributes to Endothelial Dysfunction in Aging Blood Vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Increase of arginase activity in old apolipoprotein-E deficient mice under Western diet associated with changes in neurovascular unit

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Knockdown of arginase I restores NO signaling in the vasculature of old rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

L-Arginine supplementation or arginase inhibition augments reflex cutaneous vasodilatation in aged human skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Modulating the NO generating system from a medicinal chemistry perspective: current trends and therapeutic options in cardiovascular disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

S-nitrosation of arginase 1 requires direct interaction with inducible nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Regulation of arginase pathway in response to wall shear stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVT036

21 January 2018

Identifiers

DOI

10.1093/CVR/CVT036

1 reference

28 August 2017

1 reference

PubMed ID

23417041