(Q38089133)

28 August 2017

title

G12/13-dependent signaling of G-protein-coupled receptors: disease context and impact on drug discovery (English)

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G protein-coupled receptor

28 August 2017

main subject

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1 reference

Sandra Siehler

1

1 reference

28 August 2017

language of work or name

English

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publication date

1 December 2007

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Expert Opinion on Drug Discovery

28 August 2017

published in

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28 August 2017

volume

2

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28 August 2017

issue

12

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28 August 2017

page(s)

1591-1604

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The 7 TM G-protein-coupled receptor target family

28 August 2017

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Gα12 and Gα13 as key regulatory mediator in signal transduction

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Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity

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Essential role for Galpha13 in endothelial cells during embryonic development

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G13 is an essential mediator of platelet activation in hemostasis and thrombosis

21 January 2018

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Protease-activated receptor mediated RhoA signaling and cytoskeletal reorganization in LNCaP cells

21 January 2018

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Prostaglandin E receptor EP3 subtype induces neurite retraction via small GTPase Rho.

21 January 2018

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A1 adenosine receptor activation inhibits neurite process formation by Rho kinase-mediated pathways

21 January 2018

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Galpha12- and Galpha13-protein subunit linkage of D5 dopamine receptors in the nephron

21 January 2018

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Prediction of the coupling specificity of GPCRs to four families of G-proteins using hidden Markov models and artificial neural networks

21 January 2018

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N-terminal short sequences of alpha subunits of the G12 family determine selective coupling to receptors.

21 January 2018

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Receptor-dependent RhoA activation in G12/G13-deficient cells: genetic evidence for an involvement of Gq/G11.

21 January 2018

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The G12 family of G proteins as a reporter of thromboxane A2 receptor activity

21 January 2018

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Mammalian G proteins and their cell type specific functions

21 January 2018

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21 January 2018

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Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins

21 January 2018

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Phospholipase C epsilon: linking second messengers and small GTPases

21 January 2018

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G-protein-coupled receptor agonists activate endogenous phospholipase Cepsilon and phospholipase Cbeta3 in a temporally distinct manner

21 January 2018

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Characterization of the expression of PDZ-RhoGEF, LARG and G(alpha)12/G(alpha)13 proteins in the murine nervous system.

21 January 2018

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GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

21 January 2018

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Disruption of oligomerization induces nucleocytoplasmic shuttling of leukemia-associated rho Guanine-nucleotide exchange factor.

21 January 2018

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Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF

21 January 2018

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21 January 2018

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Identification of a novel guanine nucleotide exchange factor for the Rho GTPase

21 January 2018

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p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13

21 January 2018

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Mechanisms for reversible regulation between G13 and Rho exchange factors

21 January 2018

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Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho

21 January 2018

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Protein Kinase Cα-Induced p115RhoGEF Phosphorylation Signals Endothelial Cytoskeletal Rearrangement

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2.12.1591

Identification of a novel sequence in PDZ-RhoGEF that mediates interaction with the actin cytoskeleton

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2.12.1591

Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF

21 January 2018

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Functional consequences of G alpha 13 mutations that disrupt interaction with p115RhoGEF

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.12.1591

Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2.12.1591

G alpha 13 signals via p115RhoGEF cascades regulating JNK1 and primitive endoderm formation

21 January 2018

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Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells

21 January 2018

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Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs)

21 January 2018

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The regulator of G protein signaling domain of axin selectively interacts with Galpha12 but not Galpha13.

21 January 2018

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RGS16 inhibits signalling through the G alpha 13-Rho axis

21 January 2018

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AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation

21 January 2018

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Anchoring of both PKA and 14-3-3 inhibits the Rho-GEF activity of the AKAP-Lbc signaling complex

21 January 2018

1 reference

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Leucine zipper-mediated homo-oligomerization regulates the Rho-GEF activity of AKAP-Lbc

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.2.12.1591

Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils

21 January 2018

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Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia

21 January 2018

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Selective uncoupling of G alpha 12 from Rho-mediated signaling.

21 January 2018

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Rho GTPases: biochemistry and biology

21 January 2018

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Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding

21 January 2018

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Rho localization in cells and tissues

21 January 2018

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Rho-family GTPases: it's not only Rac and Rho (and I like it).

21 January 2018

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Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function

21 January 2018

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Rac inhibits thrombin-induced Rho activation: evidence of a Pak-dependent GTPase crosstalk

21 January 2018

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Scaffold proteins dictate Rho GTPase-signaling specificity

21 January 2018

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A role for VASP in RhoA-Diaphanous signalling to actin dynamics and SRF activity

21 January 2018

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Regulation of SRF activity by Rho family GTPases.

21 January 2018

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The Rac and Rho hall of fame: a decade of hypertrophic signaling hits

21 January 2018

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The Galpha12-RGS RhoGEF-RhoA signalling pathway regulates neurotransmitter release in C. elegans

21 January 2018

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RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis

21 January 2018

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The role of sphingosine-1-phosphate in smooth muscle contraction

21 January 2018

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Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2.

21 January 2018

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RhoA/Rho-kinase pathway: much more than just a modulation of vascular tone. Evidence from studies in humans

21 January 2018

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Sphingosine 1-phosphate causes airway hyper-reactivity by rho-mediated myosin phosphatase inactivation

21 January 2018

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RHO SIGNALING in vascular diseases

21 January 2018

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G12/G13 family G proteins regulate marginal zone B cell maturation, migration, and polarization

21 January 2018

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RhoGDI-1 modulation of the activity of monomeric RhoGTPase RhoA regulates endothelial barrier function in mouse lungs

21 January 2018

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The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis

21 January 2018

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Agonist-independent activation of Gz by the 5-hydroxytryptamine1A receptor co-expressed in Spodoptera frugiperda cells. Distinguishing inverse agonists from neutral antagonists

21 January 2018

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Principles: extending the utility of [35S]GTP gamma S binding assays

21 January 2018

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The antibody-capture [(35)S]GTPgammaS scintillation proximity assay: a powerful emerging technique for analysis of GPCR pharmacology

21 January 2018

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Spatiotemporal dynamics of RhoA activity in migrating cells

21 January 2018

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Activity of Rho-family GTPases during cell division as visualized with FRET-based probes

21 January 2018

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Microgravity: the immune response and bone

21 January 2018

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Dynamics of receptor/G protein coupling in living cells

21 January 2018

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Real-time monitoring of receptor and G-protein interactions in living cells.

21 January 2018

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Efficacy at G-protein-coupled receptors

21 January 2018

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Functional Selectivity and Classical Concepts of Quantitative Pharmacology

21 January 2018

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Determination of GTP loading on Rho

21 January 2018

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10.1517/17460441.2.12.1591

21 January 2018

Identifiers

DOI

1 reference

28 August 2017

1 reference