(Q38099192)

28 August 2017

title

Emerging transporters of clinical importance: an update from the International Transporter Consortium (English)

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28 August 2017

K M Hillgren

1

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28 August 2017

D Keppler

2

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28 August 2017

A A Zur

3

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28 August 2017

K M Giacomini

4

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28 August 2017

B Stieger

5

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28 August 2017

C E Cass

6

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28 August 2017

L Zhang

7

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28 August 2017

International Transporter Consortium

8

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28 August 2017

language of work or name

English

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publication date

8 April 2013

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Clinical Pharmacology & Therapeutics

28 August 2017

published in

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28 August 2017

volume

94

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28 August 2017

issue

1

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28 August 2017

page(s)

52-63

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Membrane transporters in drug development

28 August 2017

cites work

1 reference

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Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics

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A human transporter protein that mediates the final excretion step for toxic organic cations

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MATE1 has an external COOH terminus, consistent with a 13-helix topology

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Structures of a Na+-coupled, substrate-bound MATE multidrug transporter

21 January 2018

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A common 5'-UTR variant in MATE2-K is associated with poor response to metformin

21 January 2018

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Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1

21 January 2018

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Molecular determinants of ligand selectivity for the human multidrug and toxin extruder proteins MATE1 and MATE2-K.

21 January 2018

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Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling

21 January 2018

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Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study

21 January 2018

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Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy

21 January 2018

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Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins

21 January 2018

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The apical conjugate efflux pump ABCC2 (MRP2).

21 January 2018

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Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules

21 January 2018

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Transporters in human platelets: physiologic function and impact for pharmacotherapy

21 January 2018

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Multidrug resistance-associated proteins 3, 4, and 5.

21 January 2018

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Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver

21 January 2018

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Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione

21 January 2018

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Molecular characterization and inhibition of amanitin uptake into human hepatocytes

21 January 2018

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The human bile salt export pump: characterization of substrate specificity and identification of inhibitors

21 January 2018

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Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome

21 January 2018

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Genetic polymorphisms in the multidrug resistance-associated protein 3 (ABCC3, MRP3) gene and relationship to its mRNA and protein expression in human liver

21 January 2018

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Transporter-mediated protection against thiopurine-induced hematopoietic toxicity

21 January 2018

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Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.74

Physiology of bile secretion

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.74

"Let there be bile"--understanding hepatic injury in cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

21 January 2018

Bile salt transporters

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

The bile salt export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

Role of the bile salt export pump, BSEP, in acquired forms of cholestasis

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.74

Functional expression of the canalicular bile salt export pump of human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

In vitro investigation of the hepatobiliary disposition mechanisms of the antifungal agent micafungin in humans and rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

The bile salt export pump (BSEP) in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

Genetic determinants of drug-induced cholestasis and intrahepatic cholestasis of pregnancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

Genetic variations of bile salt transporters as predisposing factors for drug-induced cholestasis, intrahepatic cholestasis of pregnancy and therapeutic response of viral hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity.

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.74

Case definition and phenotype standardization in drug-induced liver injury.

21 January 2018

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The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29.

21 January 2018

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Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.74

Distinct regional distribution of human equilibrative nucleoside transporter proteins 1 and 2 (hENT1 and hENT2) in the central nervous system

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.74

The absence of human equilibrative nucleoside transporter 1 is associated with reduced survival in patients with gemcitabine-treated pancreas adenocarcinoma.

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.74

Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer.

21 January 2018

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Pharmaceutical and pharmacological importance of peptide transporters

21 January 2018

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Proton-coupled oligopeptide transporter family SLC15: physiological, pharmacological and pathological implications

21 January 2018

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Genetic polymorphisms in human proton-dependent dipeptide transporter PEPT1: implications for the functional role of Pro586.

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.74

Targeted disruption of peptide transporter Pept1 gene in mice significantly reduces dipeptide absorption in intestine

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.74

The role and pathophysiological relevance of membrane transporter PepT1 in intestinal inflammation and inflammatory bowel disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.74

In vitro methods to support transporter evaluation in drug discovery and development

21 January 2018

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https://api.crossref.org/works/10.1038%2FCLPT.2013.74

Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

Reduction of metformin renal tubular secretion by cimetidine in man

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

Effect of cimetidine and ranitidine on pharmacokinetics and pharmacodynamics of a single dose of dofetilide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

Cimetidine-procainamide pharmacokinetic interaction in man: Evidence of competition for tubular secretion of basic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

Effect of Cephalexin on the Pharmacokinetics of Metformin in Healthy Human Volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

The International Transporter Consortium: a collaborative group of scientists from academia, industry, and the FDA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

7 January 2021

Highlights from the International Transporter Consortium second workshop

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

7 January 2021

Molecular cloning, functional characterization and tissue distribution of rat H+/organic cation antiporter MATE1

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

7 January 2021

Effects of a MATE protein inhibitor, pyrimethamine, on the renal elimination of metformin at oral microdose and at therapeutic dose in healthy subjects

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

7 January 2021

Variability in human hepatic MRP4 expression: influence of cholestasis and genotype

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

7 January 2021

SLC28 genes and concentrative nucleoside transporter (CNT) proteins

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

7 January 2021

Human equilibrative nucleoside transporter (ENT) family of nucleoside and nucleobase transporter proteins

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

7 January 2021

The role of human nucleoside transporters in cellular uptake of 4'-thio-beta-D-arabinofuranosylcytosine and beta-D-arabinosylcytosine

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

7 January 2021

A comparison of the transportability, and its role in cytotoxicity, of clofarabine, cladribine, and fludarabine by recombinant human nucleoside transporters produced in three model expression systems

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2013.74

7 January 2021

Identifiers

DOI

10.1038/CLPT.2013.74

1 reference

28 August 2017

1 reference