(Q84039262)

English

Effects of a MATE protein inhibitor, pyrimethamine, on the renal elimination of metformin at oral microdose and at therapeutic dose in healthy subjects

scientific article published on 04 May 2011

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scholarly article

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Europe PubMed Central

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30 January 2020

Effects of a MATE protein inhibitor, pyrimethamine, on the renal elimination of metformin at oral microdose and at therapeutic dose in healthy subjects (English)

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30 January 2020

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30 January 2020

author name string

H Kusuhara

1

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30 January 2020

S Ito

2

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30 January 2020

Y Kumagai

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30 January 2020

M Jiang

4

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30 January 2020

T Shiroshita

5

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30 January 2020

Y Moriyama

6

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30 January 2020

K Inoue

7

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30 January 2020

Y Sugiyama

9

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30 January 2020

publication date

4 May 2011

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30 January 2020

Clinical Pharmacology & Therapeutics

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30 January 2020

89

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30 January 2020

6

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30 January 2020

837-844

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30 January 2020

Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review

1 reference

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Use of metformin in polycystic ovary syndrome

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7 January 2021

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Metformin improves vascular function in insulin-resistant rats.

1 reference

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Prevention of pancreatic cancer induction in hamsters by metformin

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Metformin reverses fatty liver disease in obese, leptin-deficient mice

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.36

7 January 2021

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The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.36

7 January 2021

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Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.36

7 January 2021

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Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.36

7 January 2021

based on heuristic

inferred from DOI database lookup

Involvement of organic cation transporter 1 in the lactic acidosis caused by metformin

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.36

7 January 2021

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Role of organic cation transporters in the renal handling of therapeutic agents and xenobiotics

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.36

7 January 2021

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Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.36

7 January 2021

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A human transporter protein that mediates the final excretion step for toxic organic cations

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.36

7 January 2021

based on heuristic

inferred from DOI database lookup

Physiological and pharmacokinetic roles of H+/organic cation antiporters (MATE/SLC47A).

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.36

7 January 2021

based on heuristic

inferred from DOI database lookup

Multidrug and toxic compound extrusion (MATE)-type proteins as anchor transporters for the excretion of metabolic waste products and xenobiotics

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.36

7 January 2021

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Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences the glucose-lowering effect of metformin in patients with diabetes: a preliminary study

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.36

7 January 2021

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The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.36

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.36

7 January 2021

based on heuristic

inferred from DOI database lookup

Potent and specific inhibition of mMate1-mediated efflux of type I organic cations in the liver and kidney by pyrimethamine

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.36

7 January 2021

based on heuristic

inferred from DOI database lookup

Pyrimethamine inhibits renal secretion of creatinine

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.36

7 January 2021

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inferred from DOI database lookup

In vitro-in vivo extrapolation of transporter-mediated clearance in the liver and kidney

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.36

7 January 2021

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Pharmacokinetics of metformin after intravenous and oral administration to man

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.36

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.36

7 January 2021

based on heuristic

inferred from DOI database lookup

Reduction of metformin renal tubular secretion by cimetidine in man

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.36

7 January 2021

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Estimation of the glomerular filtration rate in NIDDM patients from plasma creatinine concentration after cimetidine administration.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.36

7 January 2021

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Prediction of fluoroquinolone-induced elevation in serum creatinine levels: a case of drug-endogenous substance interaction involving the inhibition of renal secretion.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.36

7 January 2021

based on heuristic

inferred from DOI database lookup

Treatment of duodenal ulcer with cimetidine

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.36

7 January 2021

based on heuristic

inferred from DOI database lookup

The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.36

7 January 2021

based on heuristic

inferred from DOI database lookup

Involvement of human multidrug and toxin extrusion 1 in the drug interaction between cimetidine and metformin in renal epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2011.36

7 January 2021

based on heuristic

inferred from DOI database lookup

Membrane transporters in drug development

1 reference

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Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine

1 reference

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7 January 2021

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Physiological parameters in laboratory animals and humans

1 reference

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7 January 2021

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Correlation between in-vitro microsomal enzyme activity and whole organ hepatic elimination kinetics: analysis with a dispersion model

1 reference

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7 January 2021

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Kidney function and age are both predictors of pharmacokinetics of metformin.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/CLPT.2011.36

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21544077%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21544077%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

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