(Q38101508)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23616088%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

title

Alpha-synuclein and intracellular trafficking: impact on the spreading of Parkinson's disease pathology (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23616088%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

0 references

0 references

1 reference

1 reference

Tiago Fleming Outeiro

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23616088%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

author name string

Sibylle E Eisbach

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23616088%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

publication date

25 April 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23616088%20AND%20SRC:MED&resulttype=core&format=json

Journal of Molecular Medicine

29 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23616088%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

volume

91

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23616088%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23616088%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

page(s)

693-703

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23616088%20AND%20SRC:MED&resulttype=core&format=json

An Essay on the Shaking Palsy

29 February 2020

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Pars compacta of the substantia nigra modulates motor activity but is not involved importantly in regulating food and water intake

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Increased nigral iron content in postmortem parkinsonian brain

21 January 2018

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Dopamine turnover and glutathione oxidation: implications for Parkinson disease

21 January 2018

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Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease

21 January 2018

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Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia

21 January 2018

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Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro

21 January 2018

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Dopamine-mediated oxidation of methionine 127 in α-synuclein causes cytotoxicity and oligomerization of α-synuclein

21 January 2018

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The association of alpha-synuclein with membranes affects bilayer structure, stability, and fibril formation

21 January 2018

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alpha-Synuclein-synaptosomal membrane interactions: implications for fibrillogenesis

21 January 2018

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Lipid rafts mediate the synaptic localization of alpha-synuclein.

21 January 2018

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α-Synuclein in Parkinson disease and other neurodegenerative disorders

21 January 2018

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α-Synuclein as CSF and Blood Biomarker of Dementia with Lewy Bodies

21 January 2018

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In vivo demonstration that alpha-synuclein oligomers are toxic

21 January 2018

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A broken alpha -helix in folded alpha -Synuclein

21 January 2018

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Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

21 January 2018

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α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

21 January 2018

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A soluble α-synuclein construct forms a dynamic tetramer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Characterization of semisynthetic and naturally Nα-acetylated α-synuclein in vitro and in intact cells: implications for aggregation and cellular properties of α-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Bacterial in-cell NMR of human α-synuclein: a disordered monomer by nature?

21 January 2018

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Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

21 January 2018

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Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

21 January 2018

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Alpha-synuclein delays endoplasmic reticulum (ER)-to-Golgi transport in mammalian cells by antagonizing ER/Golgi SNAREs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Induction of neuronal cell death by Rab5A-dependent endocytosis of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Rab11a and HSP90 regulate recycling of extracellular alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Aggregation of α-synuclein in S. cerevisiae is associated with defects in endosomal trafficking and phospholipid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

α-Synuclein inhibits intersynaptic vesicle mobility and maintains recycling-pool homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

N-terminal acetylation of α-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer

21 January 2018

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Impact of N-terminal acetylation of α-synuclein on its random coil and lipid binding properties

21 January 2018

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Allostery in a disordered protein: oxidative modifications to α-synuclein act distally to regulate membrane binding

21 January 2018

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A large kindred with autosomal dominant Parkinson's disease

21 January 2018

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Mapping of a gene for Parkinson's disease to chromosome 4q21-q23

21 January 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

21 January 2018

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

21 January 2018

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alpha-Synuclein locus triplication causes Parkinson's disease

21 January 2018

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Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

21 January 2018

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Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders

21 January 2018

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Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein

21 January 2018

1 reference

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Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Yeast cells provide insight into alpha-synuclein biology and pathobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Axonal transport of membranous and nonmembranous cargoes: a unified perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Impairment of microtubule-dependent trafficking by overexpression of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Oligomeric alpha-synuclein inhibits tubulin polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Absence of alpha-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Evolution of the Rab family of small GTP-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Thousands of rab GTPases for the cell biologist

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Systematic discovery of Rab GTPases with synaptic functions in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Structural mechanisms for regulation of membrane traffic by rab GTPases

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Rab proteins in regulated exocytosis

21 January 2018

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Rab GTPases: specifying and deciphering organelle identity and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Role of Rab GTPases in membrane traffic and cell physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Abnormal alpha-synuclein interactions with Rab proteins in alpha-synuclein A30P transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Alpha-synuclein binding to rab3a in multiple system atrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

The role of Rab3A in neurotransmitter release

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

A small GTP-binding protein dissociates from synaptic vesicles during exocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Rab4 and Rab5 GTPase are required for directional mobility of endocytic vesicles in astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Rab conversion as a mechanism of progression from early to late endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Transport of ricin from endosomes to the Golgi apparatus is regulated by Rab6A and Rab6A'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Human α-synuclein modulates vesicle trafficking through its interaction with prenylated Rab acceptor protein 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Prenylated Rab acceptor protein is a receptor for prenylated small GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Evaluation of the therapeutic usefulness of botulinum neurotoxin B, C1, E, and F compared with the long lasting type A. Basis for distinct durations of inhibition of exocytosis in central neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

The tetanus neurotoxin-sensitive and insensitive routes to and from the plasma membrane: fast and slow pathways?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

SNARE-mediated membrane fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Circular dichroism (CD) spectroscopy of the assembly and disassembly of SNAREs: The proteins involved in membrane fusion in cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Alpha-synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human alpha-synuclein(1-120): implications for Lewy body disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease

21 January 2018

1 reference

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Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

R-SNARE ykt6 resides in membrane-associated protease-resistant protein particles and modulates cell cycle progression when over-expressed

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Transplanted dopaminergic neurons develop PD pathologic changes: a second case report

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Are synucleinopathies prion-like disorders?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

A deadly spread: cellular mechanisms of α-synuclein transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Identification of proteins involved in microglial endocytosis of alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Neuron-to-neuron transmission of α-synuclein fibrils through axonal transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-013-1038-9

Experimental support for the implication of oxidative stress in the genesis of parkinsonian syndromes

21 January 2018

1 reference

12 December 2020

Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma

1 reference

12 December 2020

Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain

1 reference

12 December 2020

Non-classical exocytosis of alpha-synuclein is sensitive to folding states and promoted under stress conditions

1 reference

12 December 2020

Genetics of Parkinson's disease

1 reference

12 December 2020

Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons

1 reference

12 December 2020

An essay on the shaking palsy. 1817.

1 reference

12 December 2020

Localization of Rab5 to synaptic vesicles identifies endosomal intermediate in synaptic vesicle recycling pathway

1 reference

12 December 2020

Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages).

1 reference

12 December 2020

α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer

1 reference

12 December 2020

Impaired neurotransmission caused by overexpression of α-synuclein in nigral dopamine neurons

1 reference

12 December 2020

Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis

1 reference

12 December 2020

alpha-Synuclein is phosphorylated in synucleinopathy lesions

1 reference

12 December 2020

Neuropathology in mice expressing human alpha-synuclein

1 reference

12 December 2020

A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in α-synuclein transgenic C . elegans

1 reference

12 December 2020

Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein

1 reference

12 December 2020

10.1007/S00109-013-1038-9

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23616088%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

29 February 2020

1004094474

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23616088%20AND%20SRC:MED&resulttype=core&format=json