(Q38101509)

28 August 2017

Posttranslational modifications regulate HIPK2, a driver of proliferative diseases (English)

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28 August 2017

Vera V Saul

1

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PubMed ID

23616089

28 August 2017

M Lienhard Schmitz

series ordinal

2

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28 August 2017

25 April 2013

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Journal of Molecular Medicine

28 August 2017

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28 August 2017

91

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28 August 2017

1051-1058

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28 August 2017

9

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https://scigraph.springernature.com/pub.10.1007/s00109-013-1042-0

28 August 2017

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cites work

RETRACTED: Targeted disruption of the murine homeodomain-interacting protein kinase-2 causes growth deficiency in vivo and cell cycle arrest in vitro.

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12 December 2020

Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma

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12 December 2020

Tissue microarray cytometry reveals positive impact of homeodomain interacting protein kinase 2 in colon cancer survival irrespective of p53 function

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12 December 2020

Role of the SUMO-interacting motif in HIPK2 targeting to the PML nuclear bodies and regulation of p53.

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12 December 2020

Hipk is an essential protein that promotes Notch signal transduction in the Drosophila eye by inhibition of the global co-repressor Groucho

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12 December 2020

High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas.

1 reference

12 December 2020

Active and inactive protein kinases: structural basis for regulation

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12 December 2020

Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation

1 reference

12 December 2020

Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation

1 reference

12 December 2020

Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP.

1 reference

12 December 2020

A redox-regulated SUMO/acetylation switch of HIPK2 controls the survival threshold to oxidative stress.

1 reference

12 December 2020

Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1- and p53-mediated transcription

1 reference

12 December 2020

The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues

1 reference

12 December 2020

Phosphorylation by the DHIPK2 protein kinase modulates the corepressor activity of Groucho

1 reference

12 December 2020

Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival

1 reference

12 December 2020

Control of nuclear HIPK2 localization and function by a SUMO interaction motif.

1 reference

12 December 2020

Homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity

1 reference

12 December 2020

Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis

1 reference

12 December 2020

Regulation of homeodomain-interacting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification

1 reference

12 December 2020

Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells.

1 reference

12 December 2020

Hypoxia suppresses chemotherapeutic drug-induced p53 Serine 46 phosphorylation by triggering HIPK2 degradation

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12 December 2020

Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2.

1 reference

12 December 2020

A systems approach identifies HIPK2 as a key regulator of kidney fibrosis

1 reference

12 December 2020

Integrating mechanisms of pulmonary fibrosis

1 reference

12 December 2020

MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.

1 reference

12 December 2020

Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1

1 reference

12 December 2020

HIPKs: Jack of all trades in basic nuclear activities.

1 reference

12 December 2020

Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs

1 reference

12 December 2020

Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma

1 reference

12 December 2020

PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis

1 reference

12 December 2020

The loss of the p53 activator HIPK2 is responsible for galectin-3 overexpression in well differentiated thyroid carcinomas

1 reference

12 December 2020

HIPK2 controls cytokinesis and prevents tetraploidization by phosphorylating histone H2B at the midbody

1 reference

12 December 2020

An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response.

1 reference

12 December 2020

Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR.

1 reference

12 December 2020

Signatures of mutation and selection in the cancer genome

1 reference

12 December 2020

HIPK2: a versatile switchboard regulating the transcription machinery and cell death

1 reference

12 December 2020

Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors

1 reference

12 December 2020

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

1 reference

12 December 2020

PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation

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12 December 2020

1 reference

12 December 2020

Homeodomain interacting protein kinase 2 regulates postnatal development of enteric dopaminergic neurons and glia via BMP signaling

1 reference

12 December 2020

Correlation between homeodomain-interacting protein kinase 2 and apoptosis in cervical cancer

1 reference

12 December 2020

Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes.

1 reference

12 December 2020

The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription

1 reference

12 December 2020

HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop

1 reference

12 December 2020

High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2.

1 reference

12 December 2020

HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis

1 reference

12 December 2020

Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

1 reference

12 December 2020

HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation.

1 reference

12 December 2020

The homeodomain-interacting kinase PKM (HIPK-2) modifies ND10 through both its kinase domain and a SUMO-1 interaction motif and alters the posttranslational modification of PML.

1 reference

12 December 2020

Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin.

1 reference

12 December 2020

Chromosomal instability and cancer: a complex relationship with therapeutic potential

1 reference

12 December 2020

Homeodomain-interacting protein kinase2 in human idiopathic pulmonary fibrosis

1 reference

12 December 2020

Homeodomain-interacting protein kinase regulates Hippo pathway-dependent tissue growth

1 reference

12 December 2020

10.1007/S00109-013-1042-0

Identifiers

DOI

1 reference

PubMed ID

23616089

Dimensions Publication ID

28 August 2017

0 references

1 reference

PubMed ID

23616089