(Q35518170)

English

Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin.

scientific article published on 19 October 2011

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22011578%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22011578%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

apoptotic process

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inferred from title

Giannino Del Sal

7

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14 January 2020

Stefano Gustincich

5

object named as

Stefano Gustincich

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Europe PubMed Central

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14 January 2020

author name string

Alice Grison

1

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14 January 2020

Fiamma Mantovani

2

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14 January 2020

Anna Comel

3

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14 January 2020

Elena Agostoni

4

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14 January 2020

Francesca Persichetti

6

1 reference

Europe PubMed Central

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14 January 2020

language of work or name

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publication date

19 October 2011

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14 January 2020

number of pages

6

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Proceedings of the National Academy of Sciences of the United States of America

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14 January 2020

108

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14 January 2020

44

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14 January 2020

17979-17984

1 reference

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14 January 2020

Role of p53 serine 46 in p53 target gene regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

Early and late events induced by polyQ-expanded proteins: identification of a common pathogenic property of polYQ-expanded proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

Apoptosis in Parkinson's disease: is p53 the missing link between genetic and sporadic Parkinsonism?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

Single-nucleotide polymorphisms in the p53 signaling pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

p53-family proteins and their regulators: hubs and spokes in tumor suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

Effects of caffeine in Parkinson's disease: from neuroprotection to the management of motor and non-motor symptoms.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

Targeting protein kinases in central nervous system disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

A novel functional variant (-842G>C) in the PIN1 promoter contributes to decreased risk of squamous cell carcinoma of the head and neck by diminishing the promoter activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

Modes of p53 regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

Blinded by the Light: The Growing Complexity of p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

Regulation of p53 by activated protein kinase C-delta during nitric oxide-induced dopaminergic cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

p53 tumor suppressor protein regulates the levels of huntingtin gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

Pin1 links the activities of c-Abl and p300 in regulating p73 function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

Pin1 regulates the timing of mammalian primordial germ cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

Huntington disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

27 July 2018

DNA breakage and induction of DNA damage response proteins precede the appearance of visible mutant huntingtin aggregates

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1106198108

21 January 2018

Modifications of p53 and the DNA damage response in cells expressing mutant form of the protein huntingtin

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1106198108

21 January 2018

PIN1, the cell cycle and cancer.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1106198108

21 January 2018

The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1106198108

21 January 2018

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1106198108

21 January 2018

The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1106198108

21 January 2018

The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1106198108

21 January 2018

Prolyl-isomerase Pin1 accumulates in lewy bodies of parkinson disease and facilitates formation of alpha-synuclein inclusions

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1106198108

21 January 2018

Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1106198108

21 January 2018

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1106198108

21 January 2018

Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1106198108

21 January 2018

Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1106198108

21 January 2018

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1106198108

21 January 2018

Neurodegenerative disorders and ischemic brain diseases.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1106198108

21 January 2018

Modulation of age at onset of Huntington disease patients by variations in TP53 and human caspase activated DNase (hCAD) genes

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1106198108

21 January 2018

PIN1 promoter polymorphisms are associated with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1106198108

21 January 2018

A genetic variation in the ADORA2A gene modifies age at onset in Huntington's disease.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1106198108

21 January 2018

p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3207660

26 September 2018

Identifiers

10.1073/PNAS.1106198108

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22011578%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

2011PNAS..10817979G

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PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22011578%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22011578%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

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