(Q38101608)

28 August 2017

Enhancing radiation therapy for patients with glioblastoma (English)

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28 August 2017

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3

Patrick Y Wen

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28 August 2017

Brian M Alexander

1

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PubMed ID

23617348

28 August 2017

Keith L Ligon

series ordinal

2

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28 August 2017

1 May 2013

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Expert Review of Anticancer Therapy

28 August 2017

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28 August 2017

13

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28 August 2017

5

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28 August 2017

569-581

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Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial

28 August 2017

1 reference

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

21 January 2018

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Survival and failure patterns of high-grade gliomas after three-dimensional conformal radiotherapy.

21 January 2018

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Accelerated fractionated proton/photon irradiation to 90 cobalt gray equivalent for glioblastoma multiforme: results of a phase II prospective trial.

21 January 2018

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Randomized study of brachytherapy in the initial management of patients with malignant astrocytoma.

21 January 2018

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Randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients with glioblastoma multiforme: report of Radiation Therapy Oncology Group 93-05 protoco

21 January 2018

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Assumptions in the radiotherapy of glioblastoma

21 January 2018

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Patterns of failure following treatment for glioblastoma multiforme and anaplastic astrocytoma.

21 January 2018

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Influence of DNA double-strand break rejoining on clonogenic survival and micronucleus yield in human cell lines.

21 January 2018

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Human tumor cells segregate into radiosensitivity groups that associate with ATM and TP53 status.

21 January 2018

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A quantitative overview of radiosensitivity of human tumor cells across histological type and TP53 status

21 January 2018

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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

21 January 2018

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CD133+ glioblastoma stem-like cells are radiosensitive with a defective DNA damage response compared with established cell lines.

21 January 2018

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Genotype-dependent radiosensitivity: clonogenic survival, apoptosis and cell-cycle redistribution

21 January 2018

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Systems biology modeling of the radiation sensitivity network: a biomarker discovery platform.

21 January 2018

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Differential level of DSB repair fidelity effected by nuclear protein extracts derived from radiosensitive and radioresistant human tumour cells

21 January 2018

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The p53 protein family and radiation sensitivity: Yes or no?

21 January 2018

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

21 January 2018

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The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma

21 January 2018

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Targeting DNA repair and the cell cycle in glioblastoma

21 January 2018

1 reference

Minimally cytotoxic doses of temozolomide produce radiosensitization in human glioblastoma cells regardless of MGMT expression

21 January 2018

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Temozolomide-mediated radiation enhancement in glioblastoma: a report on underlying mechanisms

21 January 2018

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In vitro and in vivo radiosensitization induced by the DNA methylating agent temozolomide

21 January 2018

1 reference

Role of cell cycle in mediating sensitivity to radiotherapy

21 January 2018

1 reference

Radiation and concomitant weekly administration of paclitaxel in patients with glioblastoma multiforme. A phase II study.

21 January 2018

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Phase II radiation therapy oncology group trial of weekly paclitaxel and conventional external beam radiation therapy for supratentorial glioblastoma multiforme

21 January 2018

1 reference

Phase III randomized study of radiotherapy plus procarbazine, lomustine, and vincristine with or without BUdR for treatment of anaplastic astrocytoma: final report of RTOG 9404.

21 January 2018

1 reference

Replication-dependent radiosensitization of human glioma cells by inhibition of poly(ADP-Ribose) polymerase: mechanisms and therapeutic potential

21 January 2018

1 reference

Anti-apoptosis mechanisms in malignant gliomas.

21 January 2018

1 reference

Targeted manipulation of apoptosis in cancer treatment

21 January 2018

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Radiosensitising agents for the radiotherapy of cancer: novel molecularly targeted approaches

21 January 2018

1 reference

Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute Anticancer Drug Screen

21 January 2018

1 reference

BCL-2 family proteins modulate radiosensitivity in human malignant glioma cells

21 January 2018

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Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation

21 January 2018

1 reference

BCL-2 family protein expression in initial and recurrent glioblastomas: modulation by radiochemotherapy

21 January 2018

1 reference

Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1.

21 January 2018

1 reference

The role of Bcl-2 family proteins in therapy responses of malignant astrocytic gliomas: Bcl2L12 and beyond

21 January 2018

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p53-dependent regulation of Mcl-1 contributes to synergistic cell death by ionizing radiation and the Bcl-2/Bcl-XL inhibitor ABT-737.

21 January 2018

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Expression and biological activity of X-linked inhibitor of apoptosis (XIAP) in human malignant glioma.

21 January 2018

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A small-molecule IAP inhibitor overcomes resistance to cytotoxic therapies in malignant gliomas in vitro and in vivo

21 January 2018

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Survivin enhances radiation resistance in primary human glioblastoma cells via caspase-independent mechanisms

21 January 2018

1 reference

Survivin inhibition and DNA double-strand break repair: a molecular mechanism to overcome radioresistance in glioblastoma.

21 January 2018

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Centrosome amplification induced by survivin suppression enhances both chromosome instability and radiosensitivity in glioma cells

21 January 2018

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A radiosensitizing effect of artesunate in glioblastoma cells is associated with a diminished expression of the inhibitor of apoptosis protein survivin

21 January 2018

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Quantitatively determined survivin expression levels are of prognostic value in human gliomas

21 January 2018

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Loss of ATM/Chk2/p53 pathway components accelerates tumor development and contributes to radiation resistance in gliomas

21 January 2018

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DNA damage response and growth factor signaling pathways in gliomagenesis and therapeutic resistance

21 January 2018

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Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas

21 January 2018

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Genome maintenance mechanisms for preventing cancer

21 January 2018

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DNA repair pathways in clinical practice: lessons from pediatric cancer susceptibility syndromes

21 January 2018

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Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells

21 January 2018

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PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways

21 January 2018

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

21 January 2018

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

21 January 2018

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Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition.

21 January 2018

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PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors.

21 January 2018

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Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

21 January 2018

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Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130.

21 January 2018

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DNA repair targeting and radiotherapy: a focus on the therapeutic ratio

21 January 2018

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In vitro and in vivo radiosensitization of glioblastoma cells by the poly (ADP-ribose) polymerase inhibitor E7016.

21 January 2018

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Regulation of Rad51 function by c-Abl in response to DNA damage

21 January 2018

1 reference

Imatinib mesylate radiosensitizes human glioblastoma cells through inhibition of platelet-derived growth factor receptor.

21 January 2018

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Human glioblastoma and carcinoma xenograft tumors treated by combined radiation and imatinib (Gleevec).

21 January 2018

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STI571 (Gleevec) improves tumor growth delay and survival in irradiated mouse models of glioblastoma

21 January 2018

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Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells.

21 January 2018

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Disassembly of MDC1 foci is controlled by ubiquitin-proteasome-dependent degradation

21 January 2018

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Proteasome function is required for DNA damage response and fanconi anemia pathway activation

21 January 2018

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Phase I trial using proteasome inhibitor bortezomib and concurrent temozolomide and radiotherapy for central nervous system malignancies

21 January 2018

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The wee1 protein kinase is required for radiation-induced mitotic delay

21 January 2018

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Control of the G2/M checkpoints after exposure to low doses of ionising radiation: implications for hyper-radiosensitivity

21 January 2018

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In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma

21 January 2018

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Targeting radiation-induced G(2) checkpoint activation with the Wee-1 inhibitor MK-1775 in glioblastoma cell lines

21 January 2018

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Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

21 January 2018

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Signaling mechanisms regulating adult neural stem cells and neurogenesis

21 January 2018

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Hedgehog signaling in glioblastoma multiforme.

21 January 2018

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Notch signaling enhances nestin expression in gliomas

21 January 2018

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Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors

21 January 2018

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Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma

21 January 2018

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Notch1 expression is upregulated in glioma and is associated with tumor progression.

21 January 2018

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Mitochondrial DNA integrity is essential for mitochondrial maturation during differentiation of neural stem cells

21 January 2018

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In vitro and in vivo characterization of a novel Hedgehog signaling antagonist in human glioblastoma cell lines.

21 January 2018

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Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

21 January 2018

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Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

21 January 2018

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Polarographic measurements of oxygen tension in human glioma and surrounding peritumoural brain tissue.

21 January 2018

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Intratumoral oxygen pressure in malignant brain tumor

21 January 2018

1 reference

Radiosensitising agents for the radiotherapy of cancer: advances in traditional and hypoxia targeted radiosensitisers

21 January 2018

1 reference

Misonidazole and irradiation in the treatment of high-grade astrocytomas: Further report of the Vienna study group

21 January 2018

1 reference

Radiation and nitroimidazoles in supratentorial high grade gliomas: a second clinical trial

21 January 2018

1 reference

Normalization of the vasculature for treatment of cancer and other diseases

21 January 2018

1 reference

Survival of patients with newly diagnosed glioblastoma multiforme treated with RSR13 and radiotherapy: results of a phase II new approaches to brain tumor therapy CNS consortium safety and efficacy study

21 January 2018

1 reference

Effect of trans sodium crocetinate on brain tumor oxygenation. Laboratory investigation

21 January 2018

1 reference

Trans-sodium crocetinate enhancing survival and glioma response on magnetic resonance imaging to radiation and temozolomide

21 January 2018

1 reference

Use of trans sodium crocetinate for sensitizing glioblastoma multiforme to radiation: laboratory investigation

21 January 2018

1 reference

Change of oxygen pressure in glioblastoma tissue under various conditions.

21 January 2018

1 reference

Phase II trial of radiotherapy after hyperbaric oxygenation with chemotherapy for high-grade gliomas

21 January 2018

1 reference

Effect of interstitial and/or systemic delivery of tirapazamine on the radiosensitivity of human glioblastoma multiforme in nude mice.

21 January 2018

1 reference

Fast neutrons compared with megavoltage X-rays in the treatment of patients with supratentorial glioblastoma: A controlled pilot study

21 January 2018

1 reference

The results of a randomised trial of mixed-schedule (neutron/photon) irradiation in the treatment of supratentorial Grade III and Grade IV astrocytoma

21 January 2018

1 reference

Report of a randomised pilot study of the treatment of patients with supratentorial gliomas using neutron irradiation.

21 January 2018

1 reference

Randomized neutron dose searching study for malignant gliomas of the brain: results of an RTOG study. Radiation Therapy Oncology Group.

21 January 2018

1 reference

Pion radiation for high grade astrocytoma: results of a randomized study.

21 January 2018

1 reference

Neon heavy charged particle radiotherapy of glioblastoma of the brain

21 January 2018

1 reference

Phase I/II clinical trial of carbon ion radiotherapy for malignant gliomas: combined X-ray radiotherapy, chemotherapy, and carbon ion radiotherapy.

21 January 2018

1 reference

The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas.

21 January 2018

1 reference

Inhibition of phosphatidylinositol-3-OH kinase/Akt signaling impairs DNA repair in glioblastoma cells following ionizing radiation

21 January 2018

1 reference

EGFRvIII and DNA double-strand break repair: a molecular mechanism for radioresistance in glioblastoma

21 January 2018

1 reference

Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells

21 January 2018

1 reference

Conversion of a radioresistant phenotype to a more sensitive one by disabling erbB receptor signaling in human cancer cells

21 January 2018

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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

21 January 2018

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Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies

21 January 2018

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Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177.

21 January 2018

1 reference

Phase II trial of erlotinib with temozolomide and radiation in patients with newly diagnosed glioblastoma multiforme

21 January 2018

1 reference

Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma

21 January 2018

1 reference

Inhibition of histone deacetylation: a strategy for tumor radiosensitization

21 January 2018

1 reference

Enhanced radiation-induced cell killing and prolongation of gammaH2AX foci expression by the histone deacetylase inhibitor MS-275.

21 January 2018

1 reference

Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid

21 January 2018

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Postradiation sensitization of the histone deacetylase inhibitor valproic acid

21 January 2018

1 reference

Modulation of radiation response by histone deacetylase inhibition

21 January 2018

1 reference

Susceptibility and radiosensitization of human glioblastoma cells to trichostatin A, a histone deacetylase inhibitor

21 January 2018

1 reference

Inhibition of Hsp90: a multitarget approach to radiosensitization

21 January 2018

1 reference

Enhanced tumor cell radiosensitivity and abrogation of G2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin

21 January 2018

1 reference

Hsp90 Inhibitors NVP-AUY922 and NVP-BEP800 May Exert a Significant Radiosensitization on Tumor Cells along with a Cell Type-Specific Cytotoxicity

21 January 2018

1 reference

Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells

21 January 2018

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Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction

21 January 2018

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Hsp90 inhibitor NVP-AUY922 enhances radiation sensitivity of tumor cell lines under hypoxia.

21 January 2018

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Inhibition of hsp90 compromises the DNA damage response to radiation

21 January 2018

1 reference

Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1586/ERA.13.44

1 reference

28 August 2017

1 reference

PubMed ID

23617348