(Q38114936)

29 August 2017

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A 'danse macabre': tau and Fyn in STEP with amyloid beta to facilitate induction of synaptic depression and excitotoxicity (English)

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29 August 2017

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1

Jannic Boehm

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29 August 2017

language of work or name

English

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publication date

1 June 2013

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European Journal of Neuroscience

29 August 2017

published in

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29 August 2017

volume

37

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29 August 2017

issue

12

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29 August 2017

page(s)

1925-1930

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Alzheimer's disease brain-derived amyloid-β-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein

29 August 2017

cites work

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21 January 2018

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Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease.

21 January 2018

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Ca2+ and synaptic plasticity.

21 January 2018

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Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

21 January 2018

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Receptor trafficking and synaptic plasticity

21 January 2018

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Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

21 January 2018

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Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice

21 January 2018

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Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

21 January 2018

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Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

21 January 2018

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

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Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration

21 January 2018

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Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

21 January 2018

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AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss

21 January 2018

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Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain

21 January 2018

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Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

21 January 2018

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Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

21 January 2018

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Aβ(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β.

21 January 2018

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APP processing and synaptic function

21 January 2018

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The prion protein as a receptor for amyloid-beta.

21 January 2018

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Metabotropic NMDA receptor function is required for β-amyloid-induced synaptic depression.

21 January 2018

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Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61

21 January 2018

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Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

21 January 2018

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Differential binding of the AP-2 adaptor complex and PSD-95 to the C-terminus of the NMDA receptor subunit NR2B regulates surface expression

21 January 2018

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Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD.

21 January 2018

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A specific amyloid-beta protein assembly in the brain impairs memory

21 January 2018

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Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake

21 January 2018

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Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization.

21 January 2018

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Enhanced synaptic transmission and reduced threshold for LTP induction in fyn-transgenic mice

21 January 2018

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Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

21 January 2018

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New developments on the role of NMDA receptors in Alzheimer's disease

21 January 2018

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AMPA receptor trafficking and synaptic plasticity

21 January 2018

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Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation

21 January 2018

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A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

21 January 2018

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Striatal enriched phosphatase 61 dephosphorylates Fyn at phosphotyrosine 420.

21 January 2018

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Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils

21 January 2018

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LTP inhibits LTD in the hippocampus via regulation of GSK3beta

21 January 2018

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Tyrosine phosphatase STEP is a tonic brake on induction of long-term potentiation

21 January 2018

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Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5

21 January 2018

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Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

21 January 2018

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Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.

21 January 2018

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Molecular determinants of NMDA receptor internalization

21 January 2018

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Src kinases: a hub for NMDA receptor regulation

21 January 2018

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Alzheimer's disease is a synaptic failure

21 January 2018

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Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

21 January 2018

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Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

21 January 2018

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Postsynaptic signaling and plasticity mechanisms

21 January 2018

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Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation.

21 January 2018

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Regulation of NMDA receptor trafficking by amyloid-beta

21 January 2018

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Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

21 January 2018

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NMDA-receptor activation but not ion flux is required for amyloid-beta induced synaptic depression

21 January 2018

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Regulation of NMDA receptors by the tyrosine kinase Fyn

21 January 2018

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Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

21 January 2018

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Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau.

21 January 2018

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beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology

21 January 2018

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Metaplasticity gated through differential regulation of GluN2A versus GluN2B receptors by Src family kinases

21 January 2018

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Linking amyloid-β and tau: amyloid-β induced synaptic dysfunction via local wreckage of the neuronal cytoskeleton.

21 January 2018

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Aβ Oligomers Cause Localized Ca2+Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

21 January 2018

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The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation.

21 January 2018

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Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model

21 January 2018

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Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses

21 January 2018

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Key Alzheimer's findings questioned

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/EJN.12251

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29 August 2017

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