(Q28771398)

23 June 2017

title

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons (English)

1 reference

23 June 2017

1 reference

0 references

1 reference

positive regulation of peptidyl-tyrosine phosphorylation

1 reference

Fyn proto-oncogene

1 reference

Prion protein

1 reference

Glutamate receptor, ionotropic, NMDA2B (epsilon 2)

1 reference

Mikhail A Kostylev

4

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Massimiliano Stagi

object named as

Massimiliano Stagi

5

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Stephen M. Strittmatter

object named as

Stephen M Strittmatter

9

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Thomas Wisniewski

object named as

Thomas Wisniewski

7

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author name string

Ji Won Um

1

1 reference

23 June 2017

Alexander Vortmeyer

6

1 reference

23 June 2017

Haakon B Nygaard

2

1 reference

23 June 2017

Jacqueline K Heiss

3

1 reference

23 June 2017

Erik C Gunther

8

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23 June 2017

language of work or name

English

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publication date

22 July 2012

1 reference

23 June 2017

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23 June 2017

volume

15

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23 June 2017

issue

9

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23 June 2017

page(s)

1227-1235

1 reference

describes a project that uses

23 June 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3431439/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model

16 March 2017

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Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

16 March 2017

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Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein

16 March 2017

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Regulation of embryonic cell adhesion by the prion protein

16 March 2017

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Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

16 March 2017

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

16 March 2017

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A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

16 March 2017

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Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome

16 March 2017

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16 March 2017

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Regulation of NMDA receptor trafficking by amyloid-beta

6 April 2017

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Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry

16 March 2017

1 reference

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

16 March 2017

1 reference

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Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice

16 March 2017

1 reference

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Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

16 March 2017

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A specific amyloid-beta protein assembly in the brain impairs memory

16 March 2017

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

16 March 2017

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Memory impairment in transgenic Alzheimer mice requires cellular prion protein

7 April 2017

1 reference

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Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease

9 May 2017

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNN.3178

Aβ neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors

23 May 2017

1 reference

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Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death

3 June 2018

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Aβ inhibition of ionic conductance in mouse basal forebrain neurons is dependent upon the cellular prion protein PrPC.

3 June 2018

1 reference

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Amyloid-β-induced synapse damage is mediated via cross-linkage of cellular prion proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

Ablation of cellular prion protein does not ameliorate abnormal neural network activity or cognitive dysfunction in the J20 line of human amyloid precursor protein transgenic mice

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse

3 June 2018

1 reference

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The prion protein as a receptor for amyloid-beta.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

Prion protein and Abeta-related synaptic toxicity impairment

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

Interaction between human prion protein and amyloid-beta (Abeta) oligomers: role OF N-terminal residues

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

Distinct pools of beta-amyloid in Alzheimer disease-affected brain: a clinicopathologic study

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

Cellular prion protein signaling in serotonergic neuronal cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

The synaptic localization of NR2B-containing NMDA receptors is controlled by interactions with PDZ proteins and AP-2.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

Src kinases: a hub for NMDA receptor regulation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

Molecular constituents of the postsynaptic density fraction revealed by proteomic analysis using multidimensional liquid chromatography-tandem mass spectrometry.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

Higher seizure susceptibility and enhanced tyrosine phosphorylation of N-methyl-D-aspartate receptor subunit 2B in fyn transgenic mice

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

Quantitative assessment of cortical synaptic density in Alzheimer's disease.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

Neuron dysfunction is induced by prion protein with an insertional mutation via a Fyn kinase and reversed by sirtuin activation in Caenorhabditis elegans.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

PrPc activation induces neurite outgrowth and differentiation in PC12 cells: role for caveolin-1 in the signal transduction pathway

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

Membrane-bound β-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

Glycogen synthase kinase 3 regulates N-methyl-D-aspartate receptor channel trafficking and function in cortical neurons.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

PrPc capping in T cells promotes its association with the lipid raft proteins reggie-1 and reggie-2 and leads to signal transduction

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431439

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22820466

12 December 2020

inferred from PubMed ID database lookup

NMDA receptor subunits epsilon 1 (NR2A) and epsilon 2 (NR2B) are substrates for Fyn in the postsynaptic density fraction isolated from the rat brain

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22820466

12 December 2020

inferred from PubMed ID database lookup

Human prion proteins expressed in Escherichia coli and purified by high-affinity column refolding

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22820466

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/NN.3178

1 reference

OpenCitations bibliographic resource ID

23 June 2017

1262807

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1262807

1 reference