(Q38118187)

29 August 2017

title

Glia and mast cells as targets for palmitoylethanolamide, an anti-inflammatory and neuroprotective lipid mediator (English)

1 reference

29 August 2017

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1 reference

Pietro Giusti

3

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author name string

Stephen D Skaper

series ordinal

1

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29 August 2017

Laura Facci

series ordinal

2

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29 August 2017

publication date

28 June 2013

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29 August 2017

published in

Molecular Neurobiology

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29 August 2017

volume

48

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29 August 2017

issue

2

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29 August 2017

page(s)

340-352

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Mast cells: the immune gate to the brain

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Elevated mast cell tryptase in cerebrospinal fluid of multiple sclerosis patients

21 January 2018

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Mast cell activation by myelin through scavenger receptor.

21 January 2018

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Brain mast cells link the immune system to anxiety-like behavior

21 January 2018

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P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury.

21 January 2018

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Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

21 January 2018

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Behavioral phenotypes of mice lacking purinergic P2X4 receptors in acute and chronic pain assays

21 January 2018

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21 January 2018

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Central nervous system mast cells in peripheral inflammatory nociception

21 January 2018

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Inflammation and hyperalgesia induced by nerve injury in the rat: a key role of mast cells

21 January 2018

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Mast cell degranulation distinctly activates trigemino-cervical and lumbosacral pain pathways and elicits widespread tactile pain hypersensitivity

21 January 2018

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Sensitization to mechanical stimulation by inflammatory mediators and by mild burn in canine visceral nociceptors in vitro

21 January 2018

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Mast cells synthesize, store, and release nerve growth factor

21 January 2018

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Nerve growth factor: from neurotrophin to neurokine

21 January 2018

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Systemic glucocorticoid therapy reduces pain and the number of endoneurial tumor necrosis factor-alpha (TNFalpha)-positive mast cells in rats with a painful peripheral neuropathy

21 January 2018

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The inflammatory response in stroke

21 January 2018

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Microglia: active sensor and versatile effector cells in the normal and pathologic brain

21 January 2018

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Mast cells in the brain: evidence and functional significance.

21 January 2018

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21 January 2018

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Microglia and inflammation: impact on developmental brain injuries

21 January 2018

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Mast cells are early responders after hypoxia-ischemia in immature rat brain.

21 January 2018

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21 January 2018

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The many faces of tumor necrosis factor in stroke

21 January 2018

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Cerebral mast cells regulate early ischemic brain swelling and neutrophil accumulation

21 January 2018

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Stroke induces histamine accumulation and mast cell degranulation in the neonatal rat brain

21 January 2018

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Traumatic brain injury results in mast cell increase and changes in regulation of central histamine receptors

21 January 2018

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Mast cells as early responders in the regulation of acute blood-brain barrier changes after cerebral ischemia and hemorrhage

21 January 2018

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Cerebral mast cells mediate blood-brain barrier disruption in acute experimental ischemic stroke through perivascular gelatinase activation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Microglia in health and disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Experimental autoimmune encephalomyelitis repressed by microglial paralysis.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Identification of a microglia phenotype supportive of remyelination

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Mast Cells Exert Effects Outside the Central Nervous System to Influence Experimental Allergic Encephalomyelitis Disease Course

21 January 2018

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Bone marrow-derived mast cells accumulate in the central nervous system during inflammation but are dispensable for experimental autoimmune encephalomyelitis pathogenesis

21 January 2018

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Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer's disease

21 January 2018

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Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid.

21 January 2018

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Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia

21 January 2018

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Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain.

21 January 2018

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Neuroprotective effect of exogenous microglia in global brain ischemia.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Neuroprotective function for ramified microglia in hippocampal excitotoxicity

21 January 2018

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Microglial interactions with synapses are modulated by visual experience

21 January 2018

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Early activation of microglia triggers long-lasting impairment of adult neurogenesis in the olfactory bulb.

21 January 2018

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Microglia and mast cells: two tracks on the road to neuroinflammation

21 January 2018

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Evidence for the existence of histamine H1- and H2-receptors on astrocytes of cultured rat central nervous system

21 January 2018

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Immune function of astrocytes

21 January 2018

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Signaling pathways in the activation of mast cells cocultured with astrocytes and colocalization of both cells in experimental allergic encephalomyelitis

21 January 2018

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Signal pathways in astrocytes activated by cross-talk between of astrocytes and mast cells through CD40-CD40L

21 January 2018

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Glial cells and chronic pain

21 January 2018

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Chemical genetics of neuroinflammation: natural and synthetic compounds as microglial inhibitors

21 January 2018

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Involvement of mast cells in a mouse model of postoperative pain

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration.

21 January 2018

1 reference

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The endocannabinoid system as an emerging target of pharmacotherapy

21 January 2018

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Bioactive long chain N-acylethanolamines in five species of edible bivalve molluscs. Possible implications for mollusc physiology and sea food industry

21 January 2018

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Occurrence and metabolism of anandamide and related acyl-ethanolamides in ovaries of the sea urchin Paracentrotus lividus.

21 January 2018

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Evidence for an endocannabinoid system in the central nervous system of the leech Hirudo medicinalis

21 January 2018

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Molecular characterization of a phospholipase D generating anandamide and its congeners

21 January 2018

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The effect of egg yolk in diets on anaphylactic arthritis (passive Arthus phenomenon) in the guinea pig

21 January 2018

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N-(2-hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation

21 January 2018

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Control of pain initiation by endogenous cannabinoids.

21 January 2018

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Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice

21 January 2018

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21 January 2018

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Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide

21 January 2018

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Effects of palmitoylethanolamide on immunologically induced histamine, PGD2 and TNFalpha release from canine skin mast cells

21 January 2018

1 reference

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Massive accumulation of N-acylethanolamines after stroke. Cell signalling in acute cerebral ischemia?

21 January 2018

1 reference

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Release of fatty acid amides in a patient with hemispheric stroke: a microdialysis study

21 January 2018

1 reference

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High levels of N-palmitoylethanolamide and N-stearoylethanolamide in microdialysate samples from myalgic trapezius muscle in women

21 January 2018

1 reference

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Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain

21 January 2018

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Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide.

21 January 2018

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Therapeutic effect of the endogenous fatty acid amide, palmitoylethanolamide, in rat acute inflammation: inhibition of nitric oxide and cyclo-oxygenase systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Palmitoylethanolamide reduces formalin-induced neuropathic-like behaviour through spinal glial/microglial phenotypical changes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-kappaB nuclear signalling in dorsal root ganglia

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Inhibitory effect of anandamide on resiniferatoxin-induced sensory neuropeptide release in vivo and neuropathic hyperalgesia in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB(1), TRPV1 and PPARgamma receptors and neurotrophic factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

The endocannabinoid system is modulated in response to spinal cord injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Effects of palmitoylethanolamide on release of mast cell peptidases and neurotrophic factors after spinal cord injury.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Effects of palmitoylethanolamide on signaling pathways implicated in the development of spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Palmitoylethanolamide protects against the amyloid-β25-35-induced learning and memory impairment in mice, an experimental model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Use of non-steroidal anti-inflammatory drugs and risk of Parkinson's disease: nested case-control study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Neuroprotective activities of palmitoylethanolamide in an animal model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Reduction of ischemic brain injury by administration of palmitoylethanolamide after transient middle cerebral artery occlusion in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Administration of palmitoylethanolamide (PEA) protects the neurovascular unit and reduces secondary injury after traumatic brain injury in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Palmitoylethanolamide stimulation induces allopregnanolone synthesis in C6 Cells and primary astrocytes: involvement of peroxisome-proliferator activated receptor-α.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Palmitoylethanolamide counteracts reactive astrogliosis induced by β-amyloid peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Effects of intra-ventrolateral periaqueductal grey palmitoylethanolamide on thermoceptive threshold and rostral ventromedial medulla cell activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

'Entourage' effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Palmitoylethanolamide enhances anandamide stimulation of human vanilloid VR1 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Transient receptor potential vanilloid subtype 1 mediates microglial cell death in vivo and in vitro via Ca2+-mediated mitochondrial damage and cytochrome c release

21 January 2018

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Activation of Src-family kinases in spinal microglia contributes to mechanical hypersensitivity after nerve injury.

21 January 2018

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Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

21 January 2018

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Purification and characterization of an acid amidase selective for N-palmitoylethanolamine, a putative endogenous anti-inflammatory substance

21 January 2018

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Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation.

21 January 2018

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21 January 2018

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Repertoire of microglial and macrophage responses after spinal cord injury

21 January 2018

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A granular variant of CD63 is a regulator of repeated human mast cell degranulation

21 January 2018

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Palmitoylethanolamide restores myelinated-fibre function in patients with chemotherapy-induced painful neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series

21 January 2018

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Amyotrophic lateral sclerosis treatment with ultramicronized palmitoylethanolamide: a case report

21 January 2018

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New Targets in Pain, Non-Neuronal Cells, and the Role of Palmitoylethanolamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8487-6

Characterization of glutamate-induced formation of N-acylphosphatidylethanolamine and N-acylethanolamine in cultured neocortical neurons

21 January 2018

1 reference

12 December 2020

Regulation of the genes encoding interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1beta

1 reference

12 December 2020

P2X(7) Receptors as a Transducer in the Co-Occurrence of Neurological/Psychiatric and Cardiovascular Disorders: A Hypothesis

1 reference

12 December 2020

Maintaining brain health by monitoring inflammatory processes: a mechanism to promote successful aging

1 reference

12 December 2020

Palmitoylethanolamide increases after focal cerebral ischemia and potentiates microglial cell motility.

1 reference

12 December 2020

Endocannabinoids control spasticity in a multiple sclerosis model

1 reference

12 December 2020

Mast cell stabilization limits hypoxic-ischemic brain damage in the immature rat

1 reference

12 December 2020

Design and synthesis of potent N-acylethanolamine-hydrolyzing acid amidase (NAAA) inhibitor as anti-inflammatory compounds

1 reference

12 December 2020

Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase

1 reference

12 December 2020

IL-6 production by rat peritoneal mast cells is not necessarily preceded by histamine release and can be induced by bacterial lipopolysaccharide.

1 reference

12 December 2020

The microglial-motoneuron dialogue in ALS

1 reference

12 December 2020

Mast cells migrate from blood to brain.

1 reference

12 December 2020

Acute Intracerebroventricular Administration of Palmitoylethanolamide, an Endogenous Peroxisome Proliferator-Activated Receptor- Agonist, Modulates Carrageenan-Induced Paw Edema in Mice

1 reference

12 December 2020

Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo

1 reference

12 December 2020

Mast cell activation causes delayed neurodegeneration in mixed hippocampal cultures via the nitric oxide pathway

1 reference

12 December 2020

Changes in cytokines and neurotrophins in Parkinson's disease

1 reference

12 December 2020

Increased cerebrospinal fluid concentration of nitrite in Parkinson's disease

1 reference

12 December 2020

Characterization of functional vanilloid receptors expressed by mast cells.

1 reference

12 December 2020

Conference report: 1st workshop on "palmitoylethanolamide: biochemistry, pharmacology and therapeutic use of a pleiotropic anti-inflammatory lipid mediator"

1 reference

12 December 2020

Multimodal stepped care approach with acupuncture and PPAR-α agonist palmitoylethanolamide in the treatment of a patient with multiple sclerosis and central neuropathic pain

1 reference

12 December 2020

Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

1 reference

12 December 2020

Microglia and macrophages are the major source of tumor necrosis factor in permanent middle cerebral artery occlusion in mice

1 reference

12 December 2020

Non-steroidal anti-inflammatory drugs as disease-modifying agents for Parkinson's disease: evidence from observational studies

1 reference

12 December 2020

Glial proinflammatory cytokines mediate exaggerated pain states: implications for clinical pain.

1 reference

12 December 2020

10.1007/S12035-013-8487-6

Identifiers

DOI

1 reference

Dimensions Publication ID

29 August 2017

1039256446

0 references

1 reference