(Q38120561)

29 August 2017

title

Targeting quorum sensing in Pseudomonas aeruginosa biofilms: current and emerging inhibitors (English)

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29 August 2017

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Pseudomonas aeruginosa

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5

Niels Høiby

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Thomas Bjarnsholt

series ordinal

2

object named as

Thomas Bjarnsholt

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29 August 2017

Tim Holm Jakobsen

1

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Peter Østrup Jensen

object named as

Peter Østrup Jensen

series ordinal

3

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Michael Givskov

object named as

Michael Givskov

series ordinal

4

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publication date

1 July 2013

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29 August 2017

number of pages

21

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based on heuristic

inferred from page(s)

published in

Future Microbiology

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29 August 2017

volume

8

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29 August 2017

issue

7

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29 August 2017

page(s)

901-921

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The role of quorum sensing in the pathogenicity of the cunning aggressor Pseudomonas aeruginosa

29 August 2017

cites work

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21 January 2018

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21 January 2018

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Antibiotic resistance of bacterial biofilms

21 January 2018

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Opportunistic infections in lung disease: Pseudomonas infections in cystic fibrosis

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Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen

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Anaerobic metabolism and quorum sensing by Pseudomonas aeruginosa biofilms in chronically infected cystic fibrosis airways: rethinking antibiotic treatment strategies and drug targets.

21 January 2018

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Establishment of Pseudomonas aeruginosa infection: lessons from a versatile opportunist

21 January 2018

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Nosocomial infections due to multidrug-resistant Pseudomonas aeruginosa: epidemiology and treatment options

21 January 2018

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Budget impact model of tobramycin inhalation solution for treatment ofPseudomonas aeruginosain cystic fibrosis patients

21 January 2018

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Pathogenesis of cystic fibrosis

21 January 2018

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Chemical communication among bacteria.

21 January 2018

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Regulation of gene expression by cell-to-cell communication: acyl-homoserine lactone quorum sensing

21 January 2018

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Listening in on bacteria: acyl-homoserine lactone signalling

21 January 2018

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Quorum Sensing in Bacteria

21 January 2018

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Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes

21 January 2018

1 reference

A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa

21 January 2018

1 reference

Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa

21 January 2018

1 reference

Analysis of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication

21 January 2018

1 reference

Regulation of Pseudomonas quinolone signal synthesis in Pseudomonas aeruginosa

21 January 2018

1 reference

Functions required for extracellular quinolone signaling by Pseudomonas aeruginosa

21 January 2018

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Dueling quorum sensing systems in Pseudomonas aeruginosa control the production of the Pseudomonas quinolone signal (PQS).

21 January 2018

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Mutation analysis of the Pseudomonas aeruginosa mvfR and pqsABCDE gene promoters demonstrates complex quorum-sensing circuitry

21 January 2018

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The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density-dependency of the quorum sensing hierarchy, regulates rhl-dependent genes at the onset of stationary phase and can be produced in the absence of LasR.

21 January 2018

1 reference

Quorum sensing: the power of cooperation in the world of Pseudomonas.

21 January 2018

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Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa

21 January 2018

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Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis

21 January 2018

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Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors

21 January 2018

1 reference

Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment

21 January 2018

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Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensing-controlled production of rhamnolipid by Pseudomonas aeruginosa

21 January 2018

1 reference

rhlA is required for the production of a novel biosurfactant promoting swarming motility in Pseudomonas aeruginosa: 3-(3-hydroxyalkanoyloxy)alkanoic acids (HAAs), the precursors of rhamnolipids

21 January 2018

1 reference

Quorum sensing and environmental adaptation in Pseudomonas aeruginosa: a tale of regulatory networks and multifunctional signal molecules

21 January 2018

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A network of networks: quorum-sensing gene regulation in Pseudomonas aeruginosa.

21 January 2018

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A distinct QscR regulon in the Pseudomonas aeruginosa quorum-sensing circuit

21 January 2018

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QscR, a modulator of quorum-sensing signal synthesis and virulence in Pseudomonas aeruginosa

21 January 2018

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Interactions of the quorum sensing regulator QscR: interaction with itself and the other regulators of Pseudomonas aeruginosa LasR and RhlR.

21 January 2018

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Activity of purified QscR, a Pseudomonas aeruginosa orphan quorum-sensing transcription factor

21 January 2018

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Global regulation of quorum sensing and virulence by VqsR in Pseudomonas aeruginosa

21 January 2018

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Regulation of the Pseudomonas aeruginosa quorum-sensing regulator VqsR.

21 January 2018

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The Pseudomonas aeruginosa global regulator VqsR directly inhibits QscR to control quorum-sensing and virulence gene expression

21 January 2018

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Vfr controls quorum sensing in Pseudomonas aeruginosa

21 January 2018

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The vfr gene product, required for Pseudomonas aeruginosa exotoxin A and protease production, belongs to the cyclic AMP receptor protein family

21 January 2018

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Transcriptional regulation of Pseudomonas aeruginosa rhlR: role of the CRP orthologue Vfr (virulence factor regulator) and quorum-sensing regulators LasR and RhlR.

21 January 2018

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RsaL provides quorum sensing homeostasis and functions as a global regulator of gene expression in Pseudomonas aeruginosa

21 January 2018

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The virtue of temperance: built-in negative regulators of quorum sensing in Pseudomonas

21 January 2018

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The global activator GacA of Pseudomonas aeruginosa PAO positively controls the production of the autoinducer N-butyryl-homoserine lactone and the formation of the virulence factors pyocyanin, cyanide, and lipase

21 January 2018

1 reference

Two GacA-dependent small RNAs modulate the quorum-sensing response in Pseudomonas aeruginosa

21 January 2018

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The global posttranscriptional regulator RsmA modulates production of virulence determinants and N-acylhomoserine lactones in Pseudomonas aeruginosa

21 January 2018

1 reference

Bacterial biofilms: a common cause of persistent infections

21 January 2018

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Biofilm formation as microbial development

21 January 2018

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The genomics and proteomics of biofilm formation

21 January 2018

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Influence of hydrodynamics and cell signaling on the structure and behavior of Pseudomonas aeruginosa biofilms

21 January 2018

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Genetically programmed autoinducer destruction reduces virulence gene expression and swarming motility in Pseudomonas aeruginosa PAO1.

21 January 2018

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Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants

21 January 2018

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Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development

21 January 2018

1 reference

A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms

21 January 2018

1 reference

Effects of iron on DNA release and biofilm development by Pseudomonas aeruginosa.

21 January 2018

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Pyoverdine and PQS mediated subpopulation interactions involved in Pseudomonas aeruginosa biofilm formation.

21 January 2018

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Enhanced Pseudomonas aeruginosa biofilm development mediated by human neutrophils

21 January 2018

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The involvement of cell-to-cell signals in the development of a bacterial biofilm

21 January 2018

1 reference

Statistical analysis of Pseudomonas aeruginosa biofilm development: impact of mutations in genes involved in twitching motility, cell-to-cell signaling, and stationary-phase sigma factor expression.

21 January 2018

1 reference

Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent

21 January 2018

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Influence of the hydrodynamic environment on quorum sensing in Pseudomonas aeruginosa biofilms

21 January 2018

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Does Pseudomonas aeruginosa use intercellular signalling to build biofilm communities?

21 January 2018

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The impact of quorum sensing and swarming motility on Pseudomonas aeruginosa biofilm formation is nutritionally conditional

21 January 2018

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Gene expression in Pseudomonas aeruginosa: evidence of iron override effects on quorum sensing and biofilm-specific gene regulation

21 January 2018

1 reference

Gene expression in Pseudomonas aeruginosa biofilms

21 January 2018

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Quorum-sensing genes in Pseudomonas aeruginosa biofilms: their role and expression patterns

21 January 2018

1 reference

Physiology of Pseudomonas aeruginosa in biofilms as revealed by transcriptome analysis.

21 January 2018

1 reference

Timing and localization of rhamnolipid synthesis gene expression in Pseudomonas aeruginosa biofilms

21 January 2018

1 reference

Rhamnolipid surfactant production affects biofilm architecture in Pseudomonas aeruginosa PAO1

21 January 2018

1 reference

Quorum-sensing regulation of the biofilm matrix genes (pel) of Pseudomonas aeruginosa.

21 January 2018

1 reference

Connecting quorum sensing, c-di-GMP, pel polysaccharide, and biofilm formation in Pseudomonas aeruginosa through tyrosine phosphatase TpbA (PA3885)

21 January 2018

1 reference

Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients.

21 January 2018

1 reference

A specialized wound-healing center concept: importance of a multidisciplinary department structure and surgical treatment facilities in the treatment of chronic wounds

21 January 2018

1 reference

Why chronic wounds will not heal: a novel hypothesis

21 January 2018

1 reference

Nonrandom distribution of Pseudomonas aeruginosa and Staphylococcus aureus in chronic wounds

21 January 2018

1 reference

Biofilms in chronic wounds

21 January 2018

1 reference

Distribution, organization, and ecology of bacteria in chronic wounds

21 January 2018

1 reference

Success rate of split-thickness skin grafting of chronic venous leg ulcers depends on the presence of Pseudomonas aeruginosa: a retrospective study.

21 January 2018

1 reference

Towards diagnostic guidelines for biofilm-associated infections

21 January 2018

1 reference

The immune system vs. Pseudomonas aeruginosa biofilms

21 January 2018

1 reference

Mechanisms of biofilm resistance to antimicrobial agents

21 January 2018

1 reference

Biofilms: survival mechanisms of clinically relevant microorganisms

21 January 2018

1 reference

A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance

21 January 2018

1 reference

Persister cells and the riddle of biofilm survival

21 January 2018

1 reference

The challenge of treating biofilm-associated bacterial infections.

21 January 2018

1 reference

Highly adherent small-colony variants of Pseudomonas aeruginosa in cystic fibrosis lung infection.

21 January 2018

1 reference

Macromolecular mechanisms of sputum inhibition of tobramycin activity

21 January 2018

1 reference

Cationic amphiphiles increase activity of aminoglycoside antibiotic tobramycin in the presence of airway polyelectrolytes

21 January 2018

1 reference

Extracellular DNA chelates cations and induces antibiotic resistance in Pseudomonas aeruginosa biofilms

21 January 2018

1 reference

Extracellular DNA shields against aminoglycosides in Pseudomonas aeruginosa biofilms

21 January 2018

1 reference

Inhibition of tobramycin diffusion by binding to alginate

21 January 2018

1 reference

Pseudomonas aeruginosa biofilms exposed to imipenem exhibit changes in global gene expression and beta-lactamase and alginate production.

21 January 2018

1 reference

Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients

21 January 2018

1 reference

Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis

21 January 2018

1 reference

Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes

21 January 2018

1 reference

Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria

21 January 2018

1 reference

Quorum sensing regulation in Aeromonas hydrophila

21 January 2018

1 reference

Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector

21 January 2018

1 reference

Detecting and characterizing N-acyl-homoserine lactone signal molecules by thin-layer chromatography

21 January 2018

1 reference

Detection of quorum-sensing N-acyl homoserine lactone signal molecules by bacterial biosensors

21 January 2018

1 reference

Comprehensive profiling of N-acylhomoserine lactones produced by Yersinia pseudotuberculosis using liquid chromatography coupled to hybrid quadrupole-linear ion trap mass spectrometry

21 January 2018

1 reference

A dual biosensor for 2-alkyl-4-quinolone quorum-sensing signal molecules.

21 January 2018

1 reference

Biosensor-based assays for PQS, HHQ and related 2-alkyl-4-quinolone quorum sensing signal molecules.

21 January 2018

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Detection of 2-alkyl-4-quinolones using biosensors.

21 January 2018

1 reference

Fatty acid biosynthesis in Pseudomonas aeruginosa is initiated by the FabY class of β-ketoacyl acyl carrier protein synthases

21 January 2018

1 reference

Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling

21 January 2018

1 reference

Synthetic furanones inhibit quorum-sensing and enhance bacterial clearance in Pseudomonas aeruginosa lung infection in mice

21 January 2018

1 reference

Identity and effects of quorum-sensing inhibitors produced by Penicillium species.

21 January 2018

1 reference

Bromine-, chlorine-, and mixed halogen-substituted 4-methyl-2(5H)-furanones: synthesis and mutagenic effects of halogen and hydroxyl group replacements.

21 January 2018

1 reference

New stereocontrolled synthesis and biological evaluation of 5-(1'-hydroxyalkyl)-3-methylidenetetrahydro-2-furanones as potential cytotoxic agents.

21 January 2018

1 reference

Synthesis and cytotoxicity of 3,4-diaryl-2(5H)-furanones

21 January 2018

1 reference

Quorum sensing antagonism from marine organisms

21 January 2018

1 reference

Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections

21 January 2018

1 reference

Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing

21 January 2018

1 reference

Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa

21 January 2018

1 reference

Covalent inhibition of bacterial quorum sensing.

21 January 2018

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Quorum sensing inhibitors increase the susceptibility of bacterial biofilms to antibiotics in vitro and in vivo.

21 January 2018

1 reference

Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria

21 January 2018

1 reference

Quorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways

21 January 2018

1 reference

Molecular insights into quorum sensing in the human pathogen Pseudomonas aeruginosa from the structure of the virulence regulator LasR bound to its autoinducer

21 January 2018

1 reference

Computer-aided identification of recognized drugs as Pseudomonas aeruginosa quorum-sensing inhibitors

21 January 2018

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Computational discovery of putative quorum sensing inhibitors against LasR and RhlR receptor proteins of Pseudomonas aeruginosa

21 January 2018

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Novel Pseudomonas aeruginosa quorum-sensing inhibitors identified in an ultra-high-throughput screen.

21 January 2018

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Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa

21 January 2018

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Azithromycin inhibits expression of the GacA-dependent small RNAs RsmY and RsmZ in Pseudomonas aeruginosa

21 January 2018

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Azithromycin blocks quorum sensing and alginate polymer formation and increases the sensitivity to serum and stationary-growth-phase killing of Pseudomonas aeruginosa and attenuates chronic P. aeruginosa lung infection in Cftr(-/-) mice

21 January 2018

1 reference

Inhibition of quorum sensing in Pseudomonas aeruginosa by azithromycin and its effectiveness in urinary tract infections

21 January 2018

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Quorum sensing-dependent virulence during Pseudomonas aeruginosa colonisation and pneumonia in mechanically ventilated patients

21 January 2018

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New life for an old drug: the anthelmintic drug niclosamide inhibits Pseudomonas aeruginosa quorum sensing

21 January 2018

1 reference

Interference with Pseudomonas quinolone signal synthesis inhibits virulence factor expression by Pseudomonas aeruginosa

21 January 2018

1 reference

Inhibitors of pathogen intercellular signals as selective anti-infective compounds

21 January 2018

1 reference

Identification of small-molecule antagonists of the Pseudomonas aeruginosa transcriptional regulator PqsR: biophysically guided hit discovery and optimization

21 January 2018

1 reference

Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa

21 January 2018

1 reference

Validation of PqsD as an anti-biofilm target in Pseudomonas aeruginosa by development of small-molecule inhibitors

21 January 2018

1 reference

Persister cells, dormancy and infectious disease

21 January 2018

1 reference

Bacterial biofilms: a diagnostic and therapeutic challenge

21 January 2018

1 reference

Quorum quenching quandary: resistance to antivirulence compounds

21 January 2018

1 reference

Structural insight into the oxidation-sensing mechanism of the antibiotic resistance of regulator MexR

21 January 2018

1 reference

The sociomicrobiology of antivirulence drug resistance: a proof of concept

21 January 2018

1 reference

Genetic adaptation of Pseudomonas aeruginosa during chronic lung infection of patients with cystic fibrosis: strong and weak mutators with heterogeneous genetic backgrounds emerge in mucA and/or lasR mutants

21 January 2018

1 reference

Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective

21 January 2018

1 reference

Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients

21 January 2018

1 reference

Ex vivo transcriptional profiling reveals a common set of genes important for the adaptation of Pseudomonas aeruginosa to chronically infected host sites.

21 January 2018

1 reference

Growth phenotypes of Pseudomonas aeruginosa lasR mutants adapted to the airways of cystic fibrosis patients

21 January 2018

1 reference

Impact of quorum sensing on fitness of Pseudomonas aeruginosa

21 January 2018

1 reference

Analysis of quorum sensing-deficient clinical isolates of Pseudomonas aeruginosa

21 January 2018

1 reference

Pseudomonas aeruginosa quorum-sensing systems may control virulence factor expression in the lungs of patients with cystic fibrosis.

21 January 2018

1 reference

Direct detection of N-acylhomoserine lactones in cystic fibrosis sputum.

21 January 2018

1 reference

Identification of N-acylhomoserine lactones in mucopurulent respiratory secretions from cystic fibrosis patients

21 January 2018

1 reference

Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms

21 January 2018

1 reference

Instantaneous within-patient diversity of Pseudomonas aeruginosa quorum-sensing populations from cystic fibrosis lung infections

21 January 2018

1 reference

Cooperation and conflict in quorum-sensing bacterial populations.

21 January 2018

1 reference

Cooperation and virulence of clinical Pseudomonas aeruginosa populations

21 January 2018

1 reference

Quorum sensing inhibition selects for virulence and cooperation in Pseudomonas aeruginosa

21 January 2018

1 reference

A 96-well-plate-based optical method for the quantitative and qualitative evaluation of Pseudomonas aeruginosa biofilm formation and its application to susceptibility testing

21 January 2018

1 reference

Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound.

21 January 2018

1 reference

Multiple bacterial species reside in chronic wounds: a longitudinal study

21 January 2018

1 reference

Small-Colony Variants of Pseudomonas aeruginosa in Cystic Fibrosis

21 January 2018

1 reference

A multitask biosensor for micro-volumetric detection of N-3-oxo-dodecanoyl-homoserine lactone quorum sensing signal

21 January 2018

1 reference

Impact of Pseudomonas aeruginosa quorum sensing on biofilm persistence in an in vivo intraperitoneal foreign-body infection model

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/FMB.13.57

1 reference

release_gdzhcwr5xvei3gysobgpdvepee

29 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/gdzhcwr5xvei3gysobgpdvepee

mapped directly with Wikidata item

24 November 2022

based on heuristic

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