(Q38122224)

29 August 2017

title

The kinase triad, AMPK, mTORC1 and ULK1, maintains energy and nutrient homoeostasis (English)

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29 August 2017

Elaine A Dunlop

1

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Andrew R. Tee

object named as

Andrew R Tee

series ordinal

2

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language of work or name

1 reference

1 August 2013

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Biochemical Society Transactions

29 August 2017

published in

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29 August 2017

volume

41

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29 August 2017

issue

4

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29 August 2017

page(s)

939-943

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

29 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

The TSC1-TSC2 complex: a molecular switchboard controlling cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

Raptor is phosphorylated by cdc2 during mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

Identification of a conserved motif required for mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

ATG1, an autophagy regulator, inhibits cell growth by negatively regulating S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

A comprehensive glossary of autophagy-related molecules and processes (2nd edition)

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

Regulation of mammalian autophagy in physiology and pathophysiology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

Mapping the phosphorylation sites of Ulk1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

Tor-mediated induction of autophagy via an Apg1 protein kinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

ULK1 inhibits the kinase activity of mTORC1 and cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

AMPK phosphorylation of raptor mediates a metabolic checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) is a negative regulator of the mammalian target of rapamycin complex 1 (mTORC1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

The association of AMPK with ULK1 regulates autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

The serine/threonine kinase ULK1 is a target of multiple phosphorylation events.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

Role of an intrinsically disordered conformation in AMPK-mediated phosphorylation of ULK1 and regulation of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130030

21 January 2018

Identifiers

DOI

10.1042/BST20130030

1 reference

29 August 2017

1 reference