(Q38122238)

29 August 2017

title

Activating Janus kinase pseudokinase domain mutations in myeloproliferative and other blood cancers (English)

1 reference

29 August 2017

author

Stefan N Constantinescu

object named as

Stefan N Constantinescu

1

0 references

author name string

Emilie Leroy

2

1 reference

29 August 2017

Vitalina Gryshkova

3

1 reference

29 August 2017

Christian Pecquet

4

1 reference

29 August 2017

Alexandra Dusa

5

1 reference

29 August 2017

publication date

1 August 2013

1 reference

Biochemical Society Transactions

29 August 2017

published in

1 reference

29 August 2017

volume

41

1 reference

29 August 2017

issue

4

1 reference

29 August 2017

page(s)

1048-1054

1 reference

A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130

29 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Novel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Model for growth hormone receptor activation based on subunit rotation within a receptor dimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Jaks and cytokine receptors--an intimate relationship

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Regulation of the Jak2 tyrosine kinase by its pseudokinase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Phosphorylation of Jak2 on Ser(523) inhibits Jak2-dependent leptin receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

A gain-of-function mutation of JAK2 in myeloproliferative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Substitution of pseudokinase domain residue Val-617 by large non-polar amino acids causes activation of JAK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Mutation profile of JAK2 transcripts in patients with chronic myeloproliferative neoplasias

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Germline JAK2 mutation in a family with hereditary thrombocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Impact of isolated germline JAK2V617I mutation on human hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

JAK2 V617F constitutive activation requires JH2 residue F595: a pseudokinase domain target for specific inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

The constitutive activation of Jak2-V617F is mediated by a π stacking mechanism involving phenylalanines 595 and 617.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Prediction of the structure of human Janus kinase 2 (JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Prediction of the structure of human Janus kinase 2 (JAK2) comprising JAK homology domains 1 through 7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Mechanisms of constitutive activation of Janus kinase 2-V617F revealed at the atomic level through molecular dynamics simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Regulation of JAK2 activation by Janus homology 2: evidence from molecular dynamics simulations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Ab initio modeling and experimental assessment of Janus Kinase 2 (JAK2) kinase-pseudokinase complex structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Transitions to catalytically inactive conformations in EGFR kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

A JAK2 interdomain linker relays Epo receptor engagement signals to kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Oncogenic JAK2V617F requires an intact SH2-like domain for constitutive activation and induction of a myeloproliferative disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Ligand-independent homomeric and heteromeric complexes between interleukin-2 or -9 receptor subunits and the gamma chain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

JAK mutations in high-risk childhood acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

A shift in the salt bridge interaction of residues D620 and E621 mediates the constitutive activation of Jak2-H538Q/K539L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

Activating alleles of JAK3 in acute megakaryoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20130084

21 January 2018

Identifiers

DOI

10.1042/BST20130084

1 reference

29 August 2017

1 reference