(Q38128596)

29 August 2017

Targeting protein-bound uremic toxins in chronic kidney disease (English)

1 reference

29 August 2017

Toshimitsu Niwa

1

1 reference

PubMed ID

23941498

29 August 2017

language of work or name

English

0 references

publication date

13 August 2013

1 reference

Expert Opinion on Therapeutic Targets

29 August 2017

1 reference

29 August 2017

17

1 reference

29 August 2017

11

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29 August 2017

1287-1301

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Review on uremic toxins: classification, concentration, and interindividual variability

29 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Normal and pathologic concentrations of uremic toxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Metabolomic analysis of uremic toxins by liquid chromatography/electrospray ionization-tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Metabolomic search for uremic toxins as indicators of the effect of an oral sorbent AST-120 by liquid chromatography/tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

A metabolomic approach to clarifying the effect of AST-120 on 5/6 nephrectomized rats by capillary electrophoresis with mass spectrometry (CE-MS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Colonic contribution to uremic solutes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Preventive effects of an oral sorbent on nephropathy in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-kappaB and free radical in proximal tubular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulfate induces complex redox alterations in mesangial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulfate reduces superoxide scavenging activity in the kidneys of normal and uremic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Oral sorbent AST-120 increases renal NO synthesis in uremic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Renal clearance of endogenous hippurate correlates with expression levels of renal organic anion transporters in uremic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulfate upregulates renal expression of MCP-1 via production of ROS and activation of NF-κB, p53, ERK, and JNK in proximal tubular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulfate induces epithelial-to-mesenchymal transition in rat kidneys and human proximal tubular cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulfate enhances p53-TGF-β1-Smad3 pathway in proximal tubular cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulfate-induced epithelial-to-mesenchymal transition and apoptosis of renal tubular cells as novel mechanisms of progression of renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

p-Cresol sulfate and indoxyl sulfate induce similar cellular inflammatory gene expressions in cultured proximal renal tubular cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Severely reduced production of klotho in human chronic renal failure kidney.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulfate downregulates renal expression of Klotho through production of ROS and activation of nuclear factor-ĸB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

NF-κB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

CREB, NF-κB, and NADPH oxidase coordinately upregulate indoxyl sulfate-induced angiotensinogen expression in proximal tubular cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Uremic toxins induce kidney fibrosis by activating intrarenal renin-angiotensin-aldosterone system associated epithelial-to-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulfate stimulates proliferation of rat vascular smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulfate promotes proliferation of human aortic smooth muscle cells by inducing oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulfate and atherosclerotic risk factors in hemodialysis patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulfate, a uremic toxin, promotes cell senescence in aorta of hypertensive rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulfate is a nephro-vascular toxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulfate induces nephrovascular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulphate induces oxidative stress and the expression of osteoblast-specific proteins in vascular smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelamin A through oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulfate enhances angiotensin II signaling through upregulation of epidermal growth factor receptor expression in vascular smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Enhanced expression of glucose transporter-1 in vascular smooth muscle cells via the Akt/tuberous sclerosis complex subunit 2 (TSC2)/mammalian target of rapamycin (mTOR)/ribosomal S6 protein kinase (S6K) pathway in experimental renal failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulfate inhibits nitric oxide production and cell viability by inducing oxidative stress in vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulfate upregulates expression of ICAM-1 and MCP-1 by oxidative stress-induced NF-kappaB activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Nitric oxide counters the inhibitory effects of uremic toxin indoxyl sulfate on endothelial cells by governing ERK MAP kinase and myosin light chain activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Amelioration of uremic toxin indoxyl sulfate-induced endothelial cell dysfunction by Klotho protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulfate counteracts endothelial effects of erythropoietin through suppression of Akt phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Activation of aryl hydrocarbon receptor mediates indoxyl sulfate-induced monocyte chemoattractant protein-1 expression in human umbilical vein endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Effects of indoxyl sulfate on adherens junctions of endothelial cells and the underlying signaling mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Oral activated charcoal adsorbent (AST-120) ameliorates extent and instability of atherosclerosis accelerated by kidney disease in apolipoprotein E-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Does indoxyl sulfate, a uraemic toxin, have direct effects on cardiac fibroblasts and myocytes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Chronic kidney disease-induced cardiac fibrosis is ameliorated by reducing circulating levels of a non-dialysable uremic toxin, indoxyl sulfate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Oral charcoal adsorbent (AST-120) prevents progression of cardiac damage in chronic kidney disease through suppression of oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulfate predicts cardiovascular disease and renal function deterioration in advanced chronic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

The role of protein-bound uremic toxins on peripheral artery disease and vascular access failure in patients on hemodialysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Free p-cresylsulphate is a predictor of mortality in patients at different stages of chronic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulfate, a uremic toxin, and carotid intima-media thickness in patients with coronary artery disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Relation of plasma indoxyl sulfate levels and estimated glomerular filtration rate to left ventricular diastolic dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Association between indoxyl sulfate and cardiac dysfunction and prognosis in patients with dilated cardiomyopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulfate induces skeletal resistance to parathyroid hormone in cultured osteoblastic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Association between indoxyl sulfate and skeletal resistance in hemodialysis patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Administration of oral charcoal adsorbent (AST-120) suppresses low-turnover bone progression in uraemic rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulphate inhibits osteoclast differentiation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulfate, a representative uremic toxin, suppresses erythropoietin production in a HIF-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

AST-120 (Kremezin) initiated in early stage chronic kidney disease stunts the progression of renal dysfunction in type 2 diabetic subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Effect of a carbonaceous oral adsorbent on the progression of CKD: a multicenter, randomized, controlled trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Oral ADSORBENT AST-120 decreases carotid intima-media thickness and arterial stiffness in patients with chronic renal failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Indoxyl sulfate-induced endothelial dysfunction in patients with chronic kidney disease via an induction of oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Very low protein diet reduces indoxyl sulfate levels in chronic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

The production of p-cresol sulfate and indoxyl sulfate in vegetarians versus omnivores

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Bifidobacterium in gastro-resistant seamless capsule reduces serum levels of indoxyl sulfate in patients on hemodialysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Beneficial effects of Bifidobacteria in a gastroresistant seamless capsule on hyperhomocysteinemia in hemodialysis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Effect of the super-flux cellulose triacetate dialyser membrane on the removal of non-protein-bound and protein-bound uraemic solutes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Effect of increasing dialyzer mass transfer area coefficient and dialysate flow on clearance of protein-bound solutes: a pilot crossover trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Selectively increasing the clearance of protein-bound uremic solutes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Protein-bound uraemic toxin removal in haemodialysis and post-dilution haemodiafiltration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Effective removal of protein-bound uraemic solutes by different convective strategies: a prospective trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Behavior of non-protein-bound and protein-bound uremic solutes during daily hemodialysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Increasing the clearance of protein-bound solutes by addition of a sorbent to the dialysate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

In vitro study of removal of protein-bound toxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

p-Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

Prospective Randomized Study Evaluating the Efficacy of the Spherical Adsorptive Carbon AST-120 in Chronic Kidney Disease Patients with Moderate Decrease in Renal Function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829456

10.1517/14728222.2013.829456

21 January 2018

Identifiers

DOI

1 reference

29 August 2017

1 reference

PubMed ID

23941498