(Q35835293)

English

Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation.

scientific article published on 11 January 2012

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scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22237753%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22237753%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

indoxyl sulfate

1 reference

ChEBI release 2020-05-28

hypermethylation

1 reference

based on heuristic

inferred from title

Shih-Chung Chang

2

1 reference

Europe PubMed Central

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20 January 2020

author name string

Chiao-Yin Sun

1

1 reference

Europe PubMed Central

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20 January 2020

Mai-Szu Wu

3

1 reference

Europe PubMed Central

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20 January 2020

language of work or name

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publication date

11 January 2012

1 reference

Europe PubMed Central

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20 January 2020

Kidney International

1 reference

Europe PubMed Central

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20 January 2020

81

1 reference

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20 January 2020

7

1 reference

Europe PubMed Central

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20 January 2020

640-650

1 reference

Europe PubMed Central

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20 January 2020

https://scigraph.springernature.com/pub.10.1038/ki.2011.445

0 references

Indoxyl sulfate downregulates renal expression of Klotho through production of ROS and activation of nuclear factor-ĸB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

Beyond genetics: epigenetic code in chronic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

Transcriptional activation of the human Klotho gene by epidermal growth factor in HEK293 cells; role of Egr-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

Development of DNA methyltransferase inhibitors for the treatment of neoplastic diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

Klotho and aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

Epigenetic regulation and the pathogenesis of systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

New insights into uremic toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

Oxidative stress, DNA methylation and carcinogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

Klotho as a regulator of oxidative stress and senescence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

p66shc inhibits pro-survival epidermal growth factor receptor/ERK signaling during severe oxidative stress in mouse renal proximal tubule cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

Oxidative stress modulates DNA methylation during melanocyte anchorage blockade associated with malignant transformation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

Amelioration of progressive renal injury by genetic manipulation of Klotho gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

Silencing of the metastasis suppressor RECK by RAS oncogene is mediated by DNA methyltransferase 3b-induced promoter methylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

STAT3 attenuates EGFR-mediated ERK activation and cell survival during oxidant stress in mouse proximal tubular cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter hypermethylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

The role of mammalian DNA methyltransferases in the regulation of gene expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

Suppression of aging in mice by the hormone Klotho

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

Uremic toxins: a new focus on an old subject

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

MethPrimer: designing primers for methylation PCRs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

Molecular cloning of rat klotho cDNA: markedly decreased expression of klotho by acute inflammatory stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

11 July 2018

Uremia induces abnormal oxygen consumption in tubules and aggravates chronic hypoxia of the kidney via oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

24 September 2018

Burden of chronic kidney disease: an international perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

24 September 2018

Indoxyl sulfate inhibits nitric oxide production and cell viability by inducing oxidative stress in vascular endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

24 September 2018

Association between global leukocyte DNA methylation, renal function, carotid intima-media thickness and plasma homocysteine in patients with stage 2-4 chronic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

24 September 2018

Impact of inflammation on epigenetic DNA methylation - a novel risk factor for cardiovascular disease?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

24 September 2018

P-cresylsulphate, the main in vivo metabolite of p-cresol, activates leucocyte free radical production.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

24 September 2018

Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

24 September 2018

Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

24 September 2018

Klotho reduces apoptosis in experimental ischaemic acute renal failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

24 September 2018

Klotho insufficiency causes decrease of ribosomal RNA gene transcription activity, cytoplasmic RNA and rough ER in the spinal anterior horn cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

24 September 2018

Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

24 September 2018

Expression of Klotho protein in the inner ear.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

24 September 2018

Severely reduced production of klotho in human chronic renal failure kidney.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

24 September 2018

DNA Methylation and Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3306006

15 November 2018

Oncostatin M, a cytokine released by activated mononuclear cells, induces epithelial cell-myofibroblast transdifferentiation via Jak/Stat pathway activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22237753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An oral sorbent, AST-120, increases Klotho expression and inhibits cell senescence in the kidney of uremic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22237753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Indoxyl sulfate reduces klotho expression and promotes senescence in the kidneys of hypertensive rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22237753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of uremic solutes in biological fluids of chronic kidney disease patients by HPLC assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/22237753

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/KI.2011.445

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22237753%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22237753%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22237753%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

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