(Q38134341)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24006178%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

title

Understanding the origin, activation and regulation of matrix-producing myofibroblasts for treatment of fibrotic disease (English)

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20 February 2020

1

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20 February 2020

author name string

Derek P DiRocco

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24006178%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Benjamin D Humphreys

series ordinal

3

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20 February 2020

publication date

1 November 2013

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20 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24006178%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

volume

231

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24006178%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

issue

3

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20 February 2020

page(s)

273-289

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24006178%20AND%20SRC:MED&resulttype=core&format=json

Targeting pericyte differentiation as a strategy to modulate kidney fibrosis in diabetic nephropathy

20 February 2020

cites work

1 reference

Hepatitis C virus and cellular stress response: implications to molecular pathogenesis of liver diseases

21 January 2018

1 reference

Myofibroblast-mediated mechanisms of pathological remodelling of the heart

21 January 2018

1 reference

Integrating mechanisms of pulmonary fibrosis

21 January 2018

1 reference

Host responses in tissue repair and fibrosis

21 January 2018

1 reference

The role of the myofibroblast in tumor stroma remodeling

21 January 2018

1 reference

The myofibroblast: paradigm for a mechanically active cell

21 January 2018

1 reference

Regulation of myofibroblast activities: calcium pulls some strings behind the scene

21 January 2018

1 reference

Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney

21 January 2018

1 reference

EMT in developmental morphogenesis

21 January 2018

1 reference

The basics of epithelial-mesenchymal transition

21 January 2018

1 reference

Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention

21 January 2018

1 reference

Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis

21 January 2018

1 reference

Pivotal role of pericytes in kidney fibrosis

21 January 2018

1 reference

Ecto-5'-nucleotidase is expressed by pericytes and fibroblasts in the rat heart

21 January 2018

1 reference

Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix

21 January 2018

1 reference

Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition.

21 January 2018

1 reference

Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies

21 January 2018

1 reference

BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury

21 January 2018

1 reference

Evidence that fibroblasts derive from epithelium during tissue fibrosis

21 January 2018

1 reference

Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis

21 January 2018

1 reference

Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

21 January 2018

1 reference

Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

21 January 2018

1 reference

Distinct sites of renal fibrosis in Crim1 mutant mice arise from multiple cellular origins

21 January 2018

1 reference

Conversion of vascular endothelial cells into multipotent stem-like cells

21 January 2018

1 reference

Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors.

21 January 2018

1 reference

Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells

21 January 2018

1 reference

Mesenchymal stem cell marker Stro-1 is a 75 kd endothelial antigen

21 January 2018

1 reference

A novel and simple method for culturing pericytes from mouse brain

21 January 2018

1 reference

The bone marrow functionally contributes to liver fibrosis.

21 January 2018

1 reference

A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis.

21 January 2018

1 reference

Migration of fibrocytes in fibrogenic liver injury

21 January 2018

1 reference

Anti-fibrogenic strategies and the regression of fibrosis

21 January 2018

1 reference

CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury

21 January 2018

1 reference

The role of CCL12 in the recruitment of fibrocytes and lung fibrosis.

21 January 2018

1 reference

Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis

21 January 2018

1 reference

Origin and function of myofibroblasts in kidney fibrosis

21 January 2018

1 reference

Early fibroblast progenitor cell migration to the AngII-exposed myocardium is not CXCL12 or CCL2 dependent as previously thought.

21 January 2018

1 reference

Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice

21 January 2018

1 reference

Bone marrow-derived cells contribute to infarct remodelling.

21 January 2018

1 reference

Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis.

21 January 2018

1 reference

Bone marrow-derived progenitor cells in pulmonary fibrosis

21 January 2018

1 reference

Bone marrow-derived cells do not contribute significantly to collagen I synthesis in a murine model of renal fibrosis.

21 January 2018

1 reference

Origin of renal myofibroblasts in the model of unilateral ureter obstruction in the rat.

21 January 2018

1 reference

What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis

21 January 2018

1 reference

The cellular derivation and the life span of the myofibroblast

21 January 2018

1 reference

Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis

21 January 2018

1 reference

Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development

21 January 2018

1 reference

Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2

21 January 2018

1 reference

The origin of interstitial myofibroblasts in chronic kidney disease

21 January 2018

1 reference

A pericyte origin of spinal cord scar tissue

21 January 2018

1 reference

Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury

21 January 2018

1 reference

Pericytes: developmental, physiological, and pathological perspectives, problems, and promises

21 January 2018

1 reference

Platelet-derived growth factor receptor signaling activates pericyte-myofibroblast transition in obstructive and post-ischemic kidney fibrosis.

21 January 2018

1 reference

Targeting endothelium-pericyte cross talk by inhibiting VEGF receptor signaling attenuates kidney microvascular rarefaction and fibrosis

21 January 2018

1 reference

Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice

21 January 2018

1 reference

Biological responses to PDGF-AA versus PDGF-CC in renal fibroblasts

21 January 2018

1 reference

Repetitive intratracheal bleomycin models several features of idiopathic pulmonary fibrosis

21 January 2018

1 reference

Evidence of hepatocyte apoptosis in rat liver after the administration of carbon tetrachloride

21 January 2018

1 reference

Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis

21 January 2018

1 reference

Tubular overexpression of transforming growth factor-beta1 induces autophagy and fibrosis but not mesenchymal transition of renal epithelial cells

21 January 2018

1 reference

Therapy for fibrotic diseases: nearing the starting line

21 January 2018

1 reference

The immunology of fibrosis

21 January 2018

1 reference

Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis

21 January 2018

1 reference

Tumour necrosis factor alpha signalling through activation of Kupffer cells plays an essential role in liver fibrosis of non-alcoholic steatohepatitis in mice

21 January 2018

1 reference

Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome

21 January 2018

1 reference

The NLRP3 inflammasome promotes renal inflammation and contributes to CKD.

21 January 2018

1 reference

Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent

21 January 2018

1 reference

IL-17 induces myocardial fibrosis and enhances RANKL/OPG and MMP/TIMP signaling in isoproterenol-induced heart failure.

21 January 2018

1 reference

Strategies for anti-fibrotic therapies

21 January 2018

1 reference

IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis

21 January 2018

1 reference

IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis

21 January 2018

1 reference

Fibrotic disease and the T(H)1/T(H)2 paradigm

21 January 2018

1 reference

Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses

21 January 2018

1 reference

Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.

21 January 2018

1 reference

Protection from fluorescein isothiocyanate-induced fibrosis in IL-13-deficient, but not IL-4-deficient, mice results from impaired collagen synthesis by fibroblasts

21 January 2018

1 reference

The etiology of liver damage imparts cytokines transforming growth factor beta1 or interleukin-13 as driving forces in fibrogenesis.

21 January 2018

1 reference

Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model

21 January 2018

1 reference

Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response

21 January 2018

1 reference

Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair

21 January 2018

1 reference

Conditional ablation of macrophages halts progression of crescentic glomerulonephritis

21 January 2018

1 reference

Serum amyloid P inhibits fibrosis through Fc gamma R-dependent monocyte-macrophage regulation in vivo.

21 January 2018

1 reference

Exploring the full spectrum of macrophage activation

21 January 2018

1 reference

Macrophages: master regulators of inflammation and fibrosis

21 January 2018

1 reference

Macrophage Production of TGF-? and Regulation by TGF-?

21 January 2018

1 reference

Exaggerated spontaneous release of platelet-derived growth factor by alveolar macrophages from patients with idiopathic pulmonary fibrosis

21 January 2018

1 reference

A vicious circle of alveolar macrophages and fibroblasts perpetuates pulmonary fibrosis via CCL18.

21 January 2018

1 reference

Pirfenidone inhibits macrophage infiltration in 5/6 nephrectomized rats

21 January 2018

1 reference

Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation.

21 January 2018

1 reference

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

21 January 2018

1 reference

Anti-inflammatory effect by lentiviral-mediated overexpression of IL-10 or IL-1 receptor antagonist in rat glial cells and macrophages

21 January 2018

1 reference

Transducing Hedgehog: the story so far

21 January 2018

1 reference

The mechanisms of Hedgehog signalling and its roles in development and disease

21 January 2018

1 reference

GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis

21 January 2018

1 reference

A paracrine requirement for hedgehog signalling in cancer

21 January 2018

1 reference

Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder

21 January 2018

1 reference

The role of Hedgehog signaling in fibrogenic liver repair

21 January 2018

1 reference

Expression of the developmental Sonic hedgehog (Shh) signalling pathway is up-regulated in chronic lung fibrosis and the Shh receptor patched 1 is present in circulating T lymphocytes

21 January 2018

1 reference

Hedgehog-Gli pathway activation during kidney fibrosis

21 January 2018

1 reference

Sonic hedgehog signaling mediates epithelial-mesenchymal communication and promotes renal fibrosis

21 January 2018

1 reference

The utility of hedgehog signaling pathway inhibition for cancer

21 January 2018

1 reference

Hedgehog signalling: emerging evidence for non-canonical pathways

21 January 2018

1 reference

A new look at platelet-derived growth factor in renal disease

21 January 2018

1 reference

Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation

21 January 2018

1 reference

Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing.

21 January 2018

1 reference

Cellular mechanisms of tissue fibrosis. 3. Novel mechanisms of kidney fibrosis

21 January 2018

1 reference

The role of platelet-derived growth factor signaling in healing myocardial infarcts.

21 January 2018

1 reference

Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse hearts

21 January 2018

1 reference

Platelet derived growth factor-evoked Ca2+ wave and matrix gene expression through phospholipase C in human pulmonary fibroblast

21 January 2018

1 reference

Platelet-derived growth factor (PDGF)-C neutralization reveals differential roles of PDGF receptors in liver and kidney fibrosis

21 January 2018

1 reference

Blockade of KCa3.1 ameliorates renal fibrosis through the TGF-β1/Smad pathway in diabetic mice

21 January 2018

1 reference

Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy

21 January 2018

1 reference

Constitutive upregulation of the transforming growth factor-beta pathway in rheumatoid arthritis synovial fibroblasts

21 January 2018

1 reference

The role of TGF-beta signaling in myocardial infarction and cardiac remodeling

21 January 2018

1 reference

Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis

21 January 2018

1 reference

TGF-beta and fibrosis in different organs - molecular pathway imprints

21 January 2018

1 reference

Integrins and the activation of latent transforming growth factor beta1 - an intimate relationship

21 January 2018

1 reference

Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta

21 January 2018

1 reference

Glucose stimulation of transforming growth factor-beta bioactivity in mesangial cells is mediated by thrombospondin-1.

21 January 2018

1 reference

How cells read TGF-beta signals

21 January 2018

1 reference

Reversal of acute and chronic synovial inflammation by anti-transforming growth factor beta

21 January 2018

1 reference

Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction

21 January 2018

1 reference

Smad3 deficiency attenuates renal fibrosis, inflammation,and apoptosis after unilateral ureteral obstruction.

21 January 2018

1 reference

Tyrosine kinase signaling in fibrotic disorders: Translation of basic research to human disease.

21 January 2018

1 reference

Novel anticancer targets: revisiting ERBB2 and discovering ERBB3.

21 January 2018

1 reference

Untangling the ErbB signalling network

21 January 2018

1 reference

21 January 2018

1 reference

Epidermal growth factor receptor regulates pancreatic fibrosis

21 January 2018

1 reference

A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy

21 January 2018

1 reference

Targeted expression of a dominant-negative EGF-R in the kidney reduces tubulo-interstitial lesions after renal injury

21 January 2018

1 reference

Genetic or pharmacologic blockade of EGFR inhibits renal fibrosis.

21 January 2018

1 reference

Sustained activation of EGFR triggers renal fibrogenesis after acute kidney injury

21 January 2018

1 reference

EGFR signaling promotes TGFβ-dependent renal fibrosis

21 January 2018

1 reference

Conditional expression of transforming growth factor-alpha in adult mouse lung causes pulmonary fibrosis.

21 January 2018

1 reference

EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis

21 January 2018

1 reference

Amphiregulin attenuates bleomycin-induced pneumopathy in mice.

21 January 2018

1 reference

The CCN family: a new class of inflammation modulators?

21 January 2018

1 reference

Recent developments in myofibroblast biology: paradigms for connective tissue remodeling

21 January 2018

1 reference

CCN2 is necessary for the function of mouse embryonic fibroblasts.

21 January 2018

1 reference

Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen

21 January 2018

1 reference

Regulation of hepatic stellate cells by connective tissue growth factor.

21 January 2018

1 reference

LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1.

21 January 2018

1 reference

Wnt/beta-catenin signaling in development and disease

21 January 2018

1 reference

beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds

21 January 2018

1 reference

β-catenin signaling: a novel mediator of fibrosis and potential therapeutic target

21 January 2018

1 reference

β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis

21 January 2018

1 reference

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

21 January 2018

1 reference

Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis

21 January 2018

1 reference

Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation

21 January 2018

1 reference

Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis

21 January 2018

1 reference

Targeted inhibition of β-catenin/CBP signaling ameliorates renal interstitial fibrosis

21 January 2018

1 reference

A role for Wnt-4 in renal fibrosis

21 January 2018

1 reference

Matrilysin (MMP-7) expression in renal tubular damage: association with Wnt4.

21 January 2018

1 reference

Notch signaling: the core pathway and its posttranslational regulation

21 January 2018

1 reference

Fine-tuning of the intracellular canonical Notch signaling pathway.

21 January 2018

1 reference

Bone morphogenetic protein-7 improves renal fibrosis and accelerates the return of renal function

21 January 2018

1 reference

Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans

21 January 2018

1 reference

Notch-3 receptor activation drives inflammation and fibrosis following tubulointerstitial kidney injury.

21 January 2018

1 reference

Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis

21 January 2018

1 reference

Notch1 signaling in FIZZ1 induction of myofibroblast differentiation

21 January 2018

1 reference

Characterisation of the liver progenitor cell niche in liver diseases: potential involvement of Wnt and Notch signalling

21 January 2018

1 reference

Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice.

21 January 2018

1 reference

Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/PATH.4253

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24006178%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference